KEGG   DRUG: D01674Help
Entry
D01674                      Drug                                   

Name
Naftopidil (JP16/INN);
Naftopidil tablets (JP16);
Naftopidil orally disintegrating tablets (JP16);
Flivas (TN)
Formula
C24H28N2O3
Exact mass
392.21
Mol weight
392.4907
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Therapeutic category: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Naphthalene family
alpha-Adrenergic receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01674  Naftopidil (JP16/INN); Naftopidil tablets (JP16); Naftopidil orally disintegrating tablets (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Naftopidil
      D01674  Naftopidil (JAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01674  Naftopidil
  D01674  Naftopidil tablets
  D01674  Naftopidil orally disintegrating tablets
BRITE hierarchy
Other DBs
CAS: 
57149-07-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   N1y N    20.8567  -17.7071
            2   C1x C    20.8567  -16.3024
            3   C1x C    22.0762  -15.6000
            4   N1y N    23.2885  -16.3024
            5   C1x C    23.2885  -17.7071
            6   C1x C    22.0762  -18.4095
            7   C1b C    24.4963  -15.6072
            8   C1c C    25.7094  -16.3096
            9   C1b C    26.9226  -15.6142
            10  O2a O    28.1358  -16.3165
            11  C8y C    29.3490  -15.6213
            12  O1a O    25.7064  -17.7143
            13  C8x C    29.3534  -14.2231
            14  C8x C    30.5666  -13.5279
            15  C8x C    31.7753  -14.2307
            16  C8y C    30.5575  -16.3244
            17  C8y C    31.7632  -15.6300
            18  C8x C    32.9674  -16.3271
            19  C8x C    32.9657  -17.7184
            20  C8x C    31.7601  -18.4126
            21  C8x C    30.5560  -17.7157
            22  C8y C    19.6405  -18.4102
            23  C8x C    19.6458  -19.8078
            24  C8x C    18.4295  -20.5108
            25  C8x C    17.2126  -19.8090
            26  C8x C    17.2119  -18.4042
            27  C8y C    18.4282  -17.7014
            28  O2a O    18.4316  -16.2966
            29  C1a C    17.2108  -15.5876
BOND        32
            1    13  14 1
            2    14  15 2
            3    15  17 1
            4    16  11 1
            5     1   2 1
            6     7   8 1
            7     2   3 1
            8     8   9 1
            9     3   4 1
            10    9  10 1
            11   16  17 1
            12   17  18 2
            13   18  19 1
            14   19  20 2
            15   20  21 1
            16   21  16 2
            17    4   5 1
            18    1  22 1
            19   10  11 1
            20    5   6 1
            21    8  12 1
            22    6   1 1
            23   22  23 2
            24   23  24 1
            25   24  25 2
            26   25  26 1
            27   26  27 2
            28   27  22 1
            29    4   7 1
            30   27  28 1
            31   11  13 2
            32   28  29 1

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