KEGG   DRUG: D01691Help
Entry
D01691                      Drug                                   

Name
Nipradilol (JAN/INN);
Hypadil (TN)
Formula
C15H22N2O6
Exact mass
326.1478
Mol weight
326.345
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
beta-Blocker [DS:H00612]
Remark
Therapeutic category: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01691  Nipradilol (JAN/INN)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01691  Nipradilol (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Nipradilol
      D01691  Nipradilol (JAN/INN)
    beta2-adrenergic receptor
     Nipradilol
      D01691  Nipradilol (JAN/INN)
    beta3-adrenergic receptor
     Nipradilol
      D01691  Nipradilol (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
81486-22-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    23.2500  -17.3838
            2   C8y C    22.0305  -16.6838
            3   C8y C    24.4635  -16.6838
            4   O2x O    23.2500  -18.7842
            5   C8x C    22.0305  -15.2776
            6   C1x C    20.7878  -17.3838
            7   C8x C    24.4635  -15.2776
            8   O2a O    25.6771  -17.3781
            9   C1x C    22.0362  -19.4960
            10  C8x C    23.2500  -14.5775
            11  C1y C    20.8168  -18.7901
            12  C1b C    26.8847  -16.6838
            13  C1c C    28.1041  -17.3781
            14  C1b C    29.3179  -16.6779
            15  O1a O    28.1041  -18.7842
            16  N1b N    30.5373  -17.3781
            17  C1c C    31.7507  -16.6779
            18  C1a C    32.9593  -17.3762
            19  C1a C    31.7511  -15.2820
            20  O2a O    19.6089  -19.4899
            21  N2b N    18.3990  -18.7936 #+
            22  O3a O    17.0512  -19.4934 #-
            23  O3a O    18.3969  -17.3978
BOND        24
            1     3   7 1
            2     3   8 1
            3     4   9 1
            4     5  10 1
            5     6  11 1
            6     8  12 1
            7    12  13 1
            8    13  14 1
            9    13  15 1
            10   14  16 1
            11   16  17 1
            12    7  10 2
            13    9  11 1
            14   17  18 1
            15    1   2 1
            16   17  19 1
            17    1   3 2
            18   11  20 1
            19    1   4 1
            20   20  21 1
            21    2   5 2
            22   21  22 1
            23    2   6 1
            24   21  23 2

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