KEGG   DRUG: D01691Help
Entry
D01691                      Drug                                   

Name
Nipradilol (JAN/INN);
Hypadil (TN)
Formula
C15H22N2O6
Exact mass
326.1478
Mol weight
326.345
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
beta-Blocker [DS:H00612]
Remark
Therapeutic category: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01691  Nipradilol (JAN/INN)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01691  Nipradilol (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Nipradilol
      D01691  Nipradilol (JAN/INN)
    beta2-adrenergic receptor
     Nipradilol
      D01691  Nipradilol (JAN/INN)
    beta3-adrenergic receptor
     Nipradilol
      D01691  Nipradilol (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
81486-22-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   O2a O    19.3200  -20.7900
            2   C1b C    20.5100  -20.0900
            3   C1c C    21.7000  -20.7900
            4   C1b C    22.9600  -20.0900
            5   O1a O    21.7000  -22.1900
            6   N1b N    24.1500  -20.7900
            7   C1c C    25.3400  -20.0900
            8   C1a C    26.5300  -20.7900
            9   C1a C    25.3400  -18.6900
            10  C8y C    19.3200  -22.1900
            11  C8y C    18.1076  -22.8900
            12  C8y C    18.1076  -24.2900
            13  C8x C    19.3200  -24.9900
            14  C8x C    20.5324  -24.2900
            15  C8x C    20.5324  -22.8900
            16  O2x O    16.8951  -22.1900
            17  C1x C    15.6827  -22.8900
            18  C1y C    15.6827  -24.2900
            19  C1x C    16.8951  -24.9900
            20  O2a O    14.4682  -24.9912
            21  N2b N    13.2717  -24.3002 #+
            22  O3a O    11.9449  -25.1254 #-
            23  O3a O    13.2716  -22.8903
BOND        24
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     7   9 1
            9     1  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   10  15 1
            16   11  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   12  19 1
            21   18  20 1
            22   20  21 1
            23   21  22 1
            24   21  23 2

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