KEGG   DRUG: Darifenacin hydrobromideHelp
Entry
D01699                      Drug                                   

Name
Darifenacin hydrobromide (JAN/USAN);
Enablex (TN)
Product
  Generic
Formula
C28H30N2O2. HBr
Exact mass
506.1569
Mol weight
507.4619
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
ATC code: 
Chemical group: 
Efficacy
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD10 Darifenacin
      D01699  Darifenacin hydrobromide (JAN/USAN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Darifenacin
    D01699  Darifenacin hydrobromide (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M3
     Darifenacin
      D01699  Darifenacin hydrobromide (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A
   Darifenacin
    D01699  Darifenacin hydrobromide (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01699
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01699
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01699
BRITE hierarchy
Other DBs
CAS: 
133099-07-7
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        33
            1   X   Br   23.8000  -21.2800
            2   C1x C    14.9100  -22.2600
            3   C1x C    16.3100  -22.2600
            4   C1y C    16.7426  -20.9285
            5   C1x C    15.6100  -20.1056
            6   N1y N    14.4774  -20.9285
            7   C1b C    13.2776  -20.2300
            8   C1b C    12.0651  -20.9300
            9   C8y C    10.8527  -20.2300
            10  C8x C     9.6403  -20.9300
            11  C8y C     8.4278  -20.2300
            12  C1d C    17.9424  -20.2300
            13  C8y C    19.1549  -20.9300
            14  C8y C    17.9399  -18.8301
            15  C8x C    19.1361  -18.1365
            16  C8x C    19.1335  -16.7365
            17  C8x C    17.9197  -16.0388
            18  C8x C    16.7235  -16.7324
            19  C8x C    16.7261  -18.1324
            20  C8x C    19.1549  -22.3300
            21  C8x C    20.3673  -23.0300
            22  C8x C    21.5797  -22.3300
            23  C8x C    21.5797  -20.9300
            24  C8x C    20.3673  -20.2300
            25  C8x C    10.8527  -18.8300
            26  C8x C     9.6403  -18.1300
            27  C8y C     8.4278  -18.8300
            28  O2x O     7.0963  -18.3974
            29  C1x C     6.2734  -19.5300
            30  C1x C     7.0963  -20.6626
            31  C5a C    20.9749  -18.6200
            32  O5a O    22.1796  -19.3741
            33  N1a N    21.0247  -17.2202
BOND        36
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     2   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11    4  12 1 #Down
            12   12  13 1
            13   12  14 1
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   14  19 2
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1
            26    9  25 1
            27   25  26 2
            28   26  27 1
            29   27  11 2
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   11  30 1
            34   12  31 1
            35   31  32 2
            36   31  33 1

» Japanese version   » Back

DBGET integrated database retrieval system