KEGG   DRUG: D01699Help
Entry
D01699                      Drug                                   

Name
Darifenacin hydrobromide (JAN/USAN);
Enablex (TN)
Product
Formula
C28H30N2O2. HBr
Exact mass
506.1569
Mol weight
507.4619
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment for an overactive bladder
Remark
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor M3 antagonist [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD10 Darifenacin
      D01699  Darifenacin hydrobromide (JAN/USAN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Darifenacin
    D01699  Darifenacin hydrobromide (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M3
     Darifenacin
      D01699  Darifenacin hydrobromide (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A
   Darifenacin
    D01699  Darifenacin hydrobromide (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
133099-07-7
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        33
            1   X   Br   23.8000  -21.2800
            2   C1x C    14.9100  -22.2600
            3   C1x C    16.3100  -22.2600
            4   C1y C    16.7426  -20.9285
            5   C1x C    15.6100  -20.1056
            6   N1y N    14.4774  -20.9285
            7   C1b C    13.2776  -20.2300
            8   C1b C    12.0651  -20.9300
            9   C8y C    10.8527  -20.2300
            10  C8x C     9.6403  -20.9300
            11  C8y C     8.4278  -20.2300
            12  C1d C    17.9424  -20.2300
            13  C8y C    19.1549  -20.9300
            14  C8y C    17.9399  -18.8301
            15  C8x C    19.1361  -18.1365
            16  C8x C    19.1335  -16.7365
            17  C8x C    17.9197  -16.0388
            18  C8x C    16.7235  -16.7324
            19  C8x C    16.7261  -18.1324
            20  C8x C    19.1549  -22.3300
            21  C8x C    20.3673  -23.0300
            22  C8x C    21.5797  -22.3300
            23  C8x C    21.5797  -20.9300
            24  C8x C    20.3673  -20.2300
            25  C8x C    10.8527  -18.8300
            26  C8x C     9.6403  -18.1300
            27  C8y C     8.4278  -18.8300
            28  O2x O     7.0963  -18.3974
            29  C1x C     6.2734  -19.5300
            30  C1x C     7.0963  -20.6626
            31  C5a C    20.9749  -18.6200
            32  O5a O    22.1796  -19.3741
            33  N1a N    21.0247  -17.2202
BOND        36
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     2   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11    4  12 1 #Down
            12   12  13 1
            13   12  14 1
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   14  19 2
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1
            26    9  25 1
            27   25  26 2
            28   26  27 1
            29   27  11 2
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   11  30 1
            34   12  31 1
            35   31  32 2
            36   31  33 1

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