| Entry |
|
|---|
| Name |
Roxithromycin (JP16/USAN/INN);
RXM;
Rulide (TN)
|
|---|
| Formula |
C41H76N2O15
|
|---|
| Exact mass |
836.5246
|
|---|
| Mol weight |
837.0465
|
|---|
| Structure |
     |
|---|
| Activity |
Antibacterial
|
|---|
| Remark |
Same as: Therapeutic category: ATC code: |
|---|
| Target |
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO: K01980] |
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6149 Others
D01710 Roxithromycin (JP16/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA06 Roxithromycin
D01710 Roxithromycin (JP16/USAN/INN)
Antiinfectives [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
Macrolides
Roxithromycin [ATC:J01FA06]
D01710 Roxithromycin (JP16/USAN/INN)
 |
|---|
| Other DBs |
CAS: 80214-83-1 PubChem: DrugBank: LigandBox: NIKKAJI: |
|---|
| KCF data |
ATOM 58
1 C1y C 27.8733 -17.6213
2 C1z C 27.8733 -16.2412
3 C1y C 26.6745 -18.3056
4 O2a O 29.8072 -18.3465
5 C1x C 26.6745 -15.5512
6 O1a O 28.9142 -15.2413
7 C1a C 29.1715 -16.6798
8 C1y C 26.6745 -19.6857
9 C1a C 25.6916 -17.3413
10 C1y C 31.0469 -17.6213
11 C1y C 26.6745 -14.1653
12 O2a O 27.4230 -21.0599
13 C1y C 25.4873 -20.3758
14 C1y C 31.7487 -18.8027
15 O2x O 31.7195 -16.4168
16 C2y C 25.4873 -13.4810
17 C1a C 27.8733 -13.4810
18 C1y C 28.4640 -22.1885
19 C7x C 24.2885 -19.6857
20 C1a C 25.4873 -21.7557
21 C1y C 33.1230 -18.8610
22 O1a O 31.0762 -20.0132
23 C1y C 33.0996 -16.4751
24 C1y C 24.2885 -14.1653
25 N2b N 25.4873 -12.1009
26 C1x C 28.4640 -23.5629
27 O2x O 29.6628 -21.4985
28 O7x O 24.2885 -18.3056
29 O6a O 23.2184 -20.6448
30 C1x C 33.7954 -17.5922
31 N1c N 33.8305 -19.9722
32 C1a C 33.7780 -15.2062
33 C1y C 24.2885 -15.5512
34 C1a C 23.0956 -13.4810
35 C1z C 29.6628 -24.2587
36 C1y C 30.8499 -22.1885
37 C1y C 23.0956 -17.6213
38 C1a C 34.7838 -21.3640
39 C1a C 35.2049 -19.9547
40 C1z C 23.0956 -16.2412
41 O1a O 25.4873 -16.2412
42 C1y C 30.8499 -23.5629
43 O2a O 29.6628 -25.5979
44 C1a C 31.1248 -25.2528
45 C1a C 32.0487 -21.5044
46 C1b C 21.9026 -18.3056
47 C1a C 21.8326 -16.8143
48 O1a O 21.8326 -15.5454
49 O1a O 32.0487 -24.2587
50 C1a C 30.7739 -26.5686
51 C1a C 21.9377 -19.4400
52 O2a O 24.2784 -11.3959
53 C1b C 23.0700 -12.0955
54 O2a O 21.8617 -11.3959
55 C1b C 20.6534 -12.0955
56 C1b C 19.4451 -11.3959
57 O2a O 18.2368 -12.0955
58 C1a C 17.0285 -11.3959
BOND 60
1 3 8 1
2 3 9 1 #Down
3 10 4 1 #Down
4 5 11 1
5 8 12 1 #Down
6 8 13 1
7 10 14 1
8 10 15 1
9 11 16 1
10 11 17 1 #Down
11 18 12 1 #Down
12 13 19 1
13 13 20 1 #Up
14 14 21 1
15 14 22 1 #Up
16 15 23 1
17 16 24 1
18 16 25 2
19 18 26 1
20 18 27 1
21 19 28 1
22 19 29 2
23 21 30 1
24 21 31 1 #Down
25 23 32 1 #Down
26 24 33 1
27 24 34 1 #Up
28 26 35 1
29 27 36 1
30 28 37 1
31 31 38 1
32 31 39 1
33 33 40 1
34 33 41 1 #Up
35 35 42 1
36 35 43 1 #Down
37 35 44 1
38 36 45 1 #Up
39 37 46 1 #Down
40 40 47 1 #Down
41 40 48 1 #Up
42 42 49 1 #Down
43 43 50 1
44 46 51 1
45 23 30 1
46 36 42 1
47 37 40 1
48 25 52 1
49 1 2 1
50 52 53 1
51 1 3 1
52 53 54 1
53 1 4 1 #Down
54 54 55 1
55 2 5 1
56 55 56 1
57 2 6 1 #Up
58 56 57 1
59 2 7 1 #Down
60 57 58 1
|
|---|
