KEGG   DRUG: FleroxacinHelp
Entry
D01716                      Drug                                   

Name
Fleroxacin (JAN/USAN/INN);
FLRX;
Megalocin (TN);
Megalone (TN)
Formula
C17H18F3N3O3
Exact mass
369.13
Mol weight
369.3383
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Same as: 
ATC code: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA08 Fleroxacin
      D01716  Fleroxacin (JAN/USAN/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Fleroxacin
      D01716  Fleroxacin (JAN/USAN/INN)
    Other quinolones
     Fleroxacin
      D01716  Fleroxacin (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
79660-72-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8y C    32.4934  -13.8608
            2   C8y C    32.4865  -15.2627
            3   N4y N    33.6981  -15.9735
            4   C8x C    34.9168  -15.2751
            5   C8y C    34.9239  -13.8730
            6   C8y C    33.7123  -13.1693
            7   C8y C    30.0700  -13.8608
            8   C8y C    30.0700  -15.2627
            9   C8y C    31.2879  -15.9674
            10  C8x C    31.2879  -13.1632
            11  N1y N    28.8580  -15.9645
            12  C1x C    27.6424  -15.2605
            13  C1x C    26.4345  -15.9657
            14  N1y N    26.4353  -17.3678
            15  C1x C    27.6439  -18.0648
            16  C1x C    28.8586  -17.3665
            17  O5x O    33.7426  -11.7672
            18  C6a C    36.1357  -13.1814
            19  O6a O    37.3471  -13.8851
            20  O6a O    36.1426  -11.7793
            21  X   F    28.8510  -13.1632
            22  X   F    31.2745  -17.3695
            23  C1a C    25.2155  -18.0529
            24  C1b C    33.6843  -17.3624
            25  C1b C    34.8780  -18.0676
            26  X   F    36.0868  -17.3855
BOND        28
            1     1   2 2
            2     2   3 1
            3    11  12 1
            4    12  13 1
            5    13  14 1
            6    14  15 1
            7    15  16 1
            8    16  11 1
            9     8  11 1
            10    3   4 1
            11    6  17 2
            12    7   8 1
            13    5  18 1
            14    8   9 2
            15   18  19 1
            16    9   2 1
            17   18  20 2
            18    1  10 1
            19    7  21 1
            20   10   7 2
            21    9  22 1
            22    4   5 2
            23   14  23 1
            24    5   6 1
            25    3  24 1
            26    6   1 1
            27   24  25 1
            28   25  26 1

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