KEGG   DRUG: D01717Help
Entry
D01717                      Drug                                   

Name
Levocabastine hydrochloride (JAN/USAN);
Livostin (TN)
Formula
C26H29FN2O2. HCl
Exact mass
456.198
Mol weight
456.98
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC02 Levocabastine
      D01717  Levocabastine hydrochloride (JAN/USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX02 Levocabastine
      D01717  Levocabastine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01717  Levocabastine hydrochloride (JAN/USAN)
   132  Otic and nasal agents
    1329  Others
     D01717  Levocabastine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Levocabastine
      D01717  Levocabastine hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
79547-78-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C8y C    21.0420  -18.8054
            2   C8x C    19.6403  -18.8054
            3   C8x C    18.9359  -20.0202
            4   C8y C    19.6403  -21.2280
            5   C8x C    21.0420  -21.2280
            6   C8x C    21.7394  -20.0202
            7   C8y C    30.4521  -18.8733
            8   C8x C    29.7479  -20.0846
            9   C8x C    30.4388  -21.2968
            10  C8x C    31.8410  -21.3045
            11  C8x C    32.5525  -20.1001
            12  C8x C    31.8545  -18.8810
            13  C1z C    22.2604  -18.1081
            14  C1x C    22.9507  -19.3662
            15  C1x C    24.3461  -19.3941
            16  C1y C    25.0511  -18.1169
            17  C1x C    24.3538  -16.8353
            18  C1x C    22.9585  -16.9009
            19  N1y N    26.4481  -18.1160
            20  C1x C    27.1415  -19.3332
            21  C1x C    28.5431  -19.3375
            22  C1z C    29.2514  -18.1717
            23  C1y C    28.5509  -16.8378
            24  C1x C    27.1491  -16.9034
            25  C6a C    30.4521  -17.4644
            26  C3b C    21.0420  -17.4107
            27  O6a O    31.1495  -16.2458
            28  O6a O    31.8046  -17.8236
            29  X   F    18.9289  -22.4329
            30  N3a N    19.8233  -16.7064
            31  C1a C    29.2354  -15.6437
            32  X   Cl   25.2751  -21.9960
BOND        34
            1    13  14 1
            2    14  15 1
            3    15  16 1
            4    16  17 1
            5    17  18 1
            6    18  13 1
            7     5   6 2
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   19  20 1
            14   20  21 1
            15   21  22 1
            16   22  23 1
            17   23  24 1
            18   24  19 1
            19   16  19 1 #Up
            20   12   7 1
            21   22  25 1 #Down
            22    6   1 1
            23   13  26 1 #Up
            24   13   1 1 #Down
            25   22   7 1 #Up
            26    1   2 2
            27   25  27 2
            28    2   3 1
            29   25  28 1
            30    3   4 2
            31    4  29 1
            32    4   5 1
            33   26  30 3
            34   23  31 1 #Up

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