KEGG   DRUG: D01744Help
Entry
D01744                      Drug                                   

Name
Brotizolam (JP16/USAN/INN);
Lendormin (TN)
Formula
C15H10BrClN4S
Exact mass
391.9498
Mol weight
393.6887
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Therapeutic category: 
ATC code: 
Comment
Thienodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD09 Brotizolam
      D01744  Brotizolam (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01744  Brotizolam (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Brotizolam
      D01744  Brotizolam (JAN/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01744  Brotizolam
  D01744  Brotizolam tablets
BRITE hierarchy
Other DBs
CAS: 
57801-81-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C2y C    19.2256  -17.0277
            2   C8y C    18.3366  -15.9534
            3   C8y C    18.6148  -14.5824
            4   N4y N    19.8517  -13.9512
            5   N2x N    20.6326  -16.9938
            6   C8y C    21.1316  -14.5209
            7   C1x C    21.4758  -15.8776
            8   C8y C    18.6425  -18.3050
            9   C8x C    17.2396  -18.3200
            10  C8x C    16.5511  -19.5426
            11  C8x C    17.2656  -20.7501
            12  C8x C    18.6685  -20.7351
            13  C8y C    19.3570  -19.5125
            14  X   Cl   20.7814  -19.4974
            15  S2x S    17.4668  -13.8942
            16  C8y C    16.4359  -14.8399
            17  C8x C    17.0138  -15.9725
            18  N5x N    22.0689  -13.4795
            19  N5x N    21.3682  -12.2663
            20  C8y C    19.9979  -12.5578
            21  X   Br   14.9661  -14.5703
            22  C1a C    18.9516  -11.6159
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   13  14 1
            16    3  15 1
            17   15  16 1
            18   16  17 2
            19    2  17 1
            20    6  18 2
            21   18  19 1
            22   19  20 2
            23    4  20 1
            24   16  21 1
            25   20  22 1

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