KEGG   DRUG: D01744Help
Entry
D01744                      Drug                                   

Name
Brotizolam (JP16/USAN/INN);
Lendormin (TN)
Formula
C15H10BrClN4S
Exact mass
391.9498
Mol weight
393.6887
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Therapeutic category: 
ATC code: 
Comment
Thienodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01744  Brotizolam (JP16/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD09 Brotizolam
      D01744  Brotizolam (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Brotizolam [ATC:N05CD09]
      D01744  Brotizolam (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
57801-81-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C2y C    19.1892  -17.0436
            2   C8y C    18.3462  -15.9329
            3   C8y C    18.6818  -14.5748
            4   N4y N    19.9441  -13.9961
            5   N2x N    20.5964  -17.0689
            6   C8y C    21.1989  -14.6191
            7   C1x C    21.4858  -15.9891
            8   C8y C    18.5541  -18.2946
            9   C8x C    17.1511  -18.2946
            10  C8x C    16.4495  -19.5097
            11  C8x C    17.1511  -20.7248
            12  C8x C    18.5541  -20.7248
            13  C8y C    19.2556  -19.5097
            14  X   Cl   20.6801  -19.5098
            15  S2x S    17.4938  -13.8360
            16  C8y C    16.4240  -14.7375
            17  C8x C    16.9509  -15.9634
            18  N5x N    22.1792  -13.6181
            19  N5x N    21.5301  -12.3765
            20  C8y C    20.1488  -12.6101
            21  X   Br   15.0368  -14.4093
            22  C1a C    19.1430  -11.6251
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   13  14 1
            16    3  15 1
            17   15  16 1
            18   16  17 2
            19    2  17 1
            20    6  18 2
            21   18  19 1
            22   19  20 2
            23    4  20 1
            24   16  21 1
            25   20  22 1

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