| Entry |
|
|---|
| Name |
Domperidone (JP16/USAN/INN);
Motilium (TN)
|
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| Formula |
C22H24ClN5O2
|
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| Exact mass |
425.1619
|
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| Mol weight |
425.9113
|
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| Structure |
     |
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| Activity |
Anti-emetic
|
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| Remark |
Therapeutic category: ATC code: |
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| Target |
dopamine D2-receptor antagonist [HSA: 1813] [KO: K04145] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577], CYP3A7 [HSA: 1551]
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| Interaction |
|
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| Pathway map |
|
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| Structure map |
| Dopamine receptor agonists/antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2399 Others
D01745 Domperidone (JP16/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A03F PROPULSIVES
A03FA Propulsives
A03FA03 Domperidone
D01745 Domperidone (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
dopamine D2-receptor [HSA:1813] [KO:K04145]
Domperidone [ATC:A03FA03]
D01745 Domperidone (JP16/USAN/INN)
 |
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| Other DBs |
CAS: 57808-66-9 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 30
1 N4y N 25.9465 -12.5717
2 N4y N 34.4350 -14.6429
3 C8y C 34.8727 -15.9800
4 C1y C 33.2156 -13.9485
5 C8y C 35.5889 -13.8309
6 C8y C 36.2746 -15.9263
7 C8x C 34.1655 -17.1869
8 C1x C 32.0080 -14.6486
9 C1x C 33.2799 -12.5483
10 N4x N 36.7179 -14.6653
11 O5x O 35.5323 -12.4238
12 C8x C 36.9664 -17.2144
13 C8x C 34.8520 -18.4077
14 C1x C 30.7946 -13.9544
15 C1x C 32.0022 -11.8542
16 C8y C 36.2564 -18.4160
17 N1y N 30.7888 -12.5600
18 C1b C 29.5869 -11.8599
19 C1b C 28.3735 -12.5659
20 C1b C 27.1600 -11.8658
21 X Cl 36.9447 -19.6304
22 C8y C 24.8095 -11.7498
23 N4x N 23.6813 -12.5855
24 O5x O 24.7979 -10.3542
25 C8y C 25.5313 -13.9036
26 C8y C 24.1342 -13.9107
27 C8x C 23.4416 -15.1241
28 C8x C 24.1465 -16.3307
29 C8x C 25.5436 -16.3236
30 C8x C 26.2361 -15.1100
BOND 34
1 6 12 1
2 7 13 2
3 8 14 1
4 9 15 1
5 12 16 2
6 14 17 1
7 17 18 1
8 18 19 1
9 19 20 1
10 20 1 1
11 6 10 1
12 13 16 1
13 15 17 1
14 16 21 1
15 2 3 1
16 2 4 1
17 1 22 1
18 22 23 1
19 23 26 1
20 25 1 1
21 2 5 1
22 22 24 2
23 3 6 2
24 3 7 1
25 4 8 1
26 4 9 1
27 5 10 1
28 5 11 2
29 25 26 2
30 26 27 1
31 27 28 2
32 28 29 1
33 29 30 2
34 30 25 1
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