KEGG   DRUG: D01785Help
Entry
D01785                      Drug                                   

Name
Pirmenol hydrochloride hydrate (JAN);
Pimenol (TN)
Formula
C22H30N2O. HCl. H2O
Exact mass
392.2231
Mol weight
392.9626
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic
Remark
Therapeutic category: 
Comment
Class I antiarrhythmic agent
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01785  Pirmenol hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Pirmenol
      D01785  Pirmenol hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN2A)
     Pirmenol
      D01785  Pirmenol hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN3A)
     Pirmenol
      D01785  Pirmenol hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN4A)
     Pirmenol
      D01785  Pirmenol hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN5A)
     Pirmenol
      D01785  Pirmenol hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN8A)
     Pirmenol
      D01785  Pirmenol hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN9A)
     Pirmenol
      D01785  Pirmenol hydrochloride hydrate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8x C    26.8670  -19.6231
            2   C8x C    26.8670  -21.0248
            3   C8x C    28.0838  -21.7256
            4   C8x C    29.2935  -21.0248
            5   C8y C    29.2935  -19.6231
            6   C8x C    28.0838  -18.9223
            7   C1d C    30.5080  -18.9233
            8   C8y C    31.7214  -19.6250
            9   C8x C    31.7148  -21.0246
            10  C8x C    32.9282  -21.7265
            11  C8x C    34.1425  -21.0265
            12  C8x C    34.1435  -19.6248
            13  N5x N    32.9303  -18.9231
            14  C1b C    30.5058  -17.5277
            15  C1b C    31.7163  -16.8269
            16  C1b C    31.7163  -15.4323
            17  N1y N    32.9269  -14.7315
            18  C1y C    34.1391  -15.4294
            19  C1x C    35.3498  -14.7286
            20  C1x C    35.3481  -13.3297
            21  C1x C    34.1357  -12.6318
            22  C1y C    32.9252  -13.3326
            23  C1a C    31.7104  -12.6331
            24  C1a C    34.1408  -16.8311
            25  O1a O    29.2955  -18.2233
            26  X   Cl   38.3976  -18.6187
            27  O0  O    38.7100  -16.8700
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

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