KEGG   DRUG: D01801Help
Entry
D01801                      Drug                                   

Name
Thonzylamine hydrochloride (JAN/USAN);
Super anahist (TN)
Formula
C16H22N4O. HCl
Exact mass
322.156
Mol weight
322.833
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist;
Antihistaminic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA01 Thonzylamine
      D01801  Thonzylamine hydrochloride (JAN/USAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC06 Thonzylamine
      D01801  Thonzylamine hydrochloride (JAN/USAN)
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AC Substituted ethylene diamines
     R06AC06 Thonzylamine
      D01801  Thonzylamine hydrochloride (JAN/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Thonzylamine
    D01801  Thonzylamine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Thonzylamine
      D01801  Thonzylamine hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
63-56-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   X   Cl   30.8063  -25.0296
            2   N5x N    23.8700  -23.5900
            3   C8x C    23.8700  -25.0600
            4   C8x C    25.1300  -25.7600
            5   C8x C    26.3200  -25.0600
            6   N5x N    26.3200  -23.5900
            7   C8y C    25.1300  -22.8900
            8   N1c N    25.1300  -21.4900
            9   C1b C    23.8700  -20.7900
            10  C1b C    26.3200  -20.7900
            11  C8y C    22.6800  -21.4900
            12  C8x C    21.4900  -20.7900
            13  C8x C    20.2300  -21.4900
            14  C8y C    20.2300  -22.8900
            15  C8x C    21.4200  -23.5900
            16  C8x C    22.6800  -22.8900
            17  O2a O    19.0400  -23.6600
            18  C1a C    17.7800  -22.9600
            19  C1b C    27.5100  -21.4900
            20  N1c N    28.7000  -20.7900
            21  C1a C    29.8900  -21.4900
            22  C1a C    28.7000  -19.3900
BOND        22
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     7   8 1
            8     8   9 1
            9     8  10 1
            10    9  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   14  17 1
            18   17  18 1
            19   10  19 1
            20   19  20 1
            21   20  21 1
            22   20  22 1

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