KEGG   DRUG: D01819Help
Entry
D01819                      Drug                                   

Name
Cefotiam hydrochloride (JP16/USP);
CTM;
Ceradon (TN);
Pansporin (TN)
Formula
C18H23N9O4S3. 2HCl
Exact mass
597.0569
Mol weight
598.55
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Semisynthetic cephalosporin: intermediate spectrum cephalosporin
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Interaction
Drug interaction
Structure map
Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC07 Cefotiam
      D01819  Cefotiam hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D01819  Cefotiam hydrochloride (JP16/USP)
 7  Agents not mainly for therapeutic purpose
  72  Intracorporeal diagnostic agents
   729  Miscellaneous
    7290  Miscellaneous
     D01819  Cefotiam hydrochloride (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Cephems - Cephalosporins
     Cefotiam
      D01819  Cefotiam hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01819  Cefotiam hydrochloride
  D01819  Cefotiam hydrochloride for injection
BRITE hierarchy
Other DBs
CAS: 
66309-69-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        36
            1   C1y C    11.2206  -16.3740
            2   N1y N    11.2206  -17.7676
            3   C2y C    12.4277  -18.4643
            4   C2y C    13.6347  -17.7676
            5   C1x C    13.6347  -16.3740
            6   S2x S    12.4277  -15.6771
            7   C1y C     9.8268  -16.3740
            8   C5x C     9.8268  -17.7676
            9   N1b N     8.6200  -15.6771
            10  C5a C     7.4128  -16.3740
            11  O5a O     7.4128  -17.7676
            12  O5x O     8.6200  -18.4643
            13  C1b C     6.2058  -15.6771
            14  C1b C    14.8602  -18.4755
            15  C6a C    12.4277  -19.8579
            16  O6a O    11.2038  -20.5647
            17  O6a O    13.6177  -20.5452
            18  C8y C     4.9794  -16.3856
            19  S2a S    16.0721  -17.7760
            20  C8y C    17.2788  -18.4730
            21  N5x N    17.6839  -19.8742
            22  N5x N    19.0782  -19.9044
            23  N5x N    19.5378  -18.5177
            24  N4y N    18.4274  -17.6737
            25  C8x C     3.8295  -15.5758
            26  S2x S     2.6994  -16.4195
            27  C8y C     3.1525  -17.7550
            28  N5x N     4.5626  -17.8069
            29  C1b C    18.3879  -16.2408
            30  C1b C    19.5969  -15.4975
            31  N1c N    20.8190  -16.1586
            32  C1a C    21.9853  -15.4412
            33  C1a C    20.7884  -17.5683
            34  N1a N     2.3031  -18.8948
            35  X   Cl   22.4700  -19.6700
            36  X   Cl   22.4700  -19.6700
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19   13  18 1
            20   14  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   20  24 1
            27   18  25 2
            28   25  26 1
            29   26  27 1
            30   27  28 2
            31   18  28 1
            32   24  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 1
            37   27  34 1
BRACKET     1    20.8600  -20.3700   20.8600  -18.9700
            1    23.2400  -18.9700   23.2400  -20.3700
            1  2
 ORIGINAL  1   36
 REPEAT    1   37

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