KEGG   DRUG: Landiolol hydrochlorideHelp
Entry
D01847                      Drug                                   

Name
Landiolol hydrochloride (JAN);
ONO 1101 hydrochloride;
Onoact (TN)
Formula
C25H39N3O8. HCl
Exact mass
545.2504
Mol weight
546.0534
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Activity
Antiarrhythmic, beta1-Adrenergic receptor antagonist
Target
ADRB1 [HSA:153] [KO:K04141]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB14 Landiolol
      D01847  Landiolol hydrochloride (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D01847  Landiolol hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Landiolol
      D01847  Landiolol hydrochloride (JAN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01847
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01847
BRITE hierarchy
Other DBs
CAS: 
144481-98-1
PubChem: 
ChEBI: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        37
            1   X   Cl   33.6000  -21.0700
            2   C1y C    25.3400  -19.4600
            3   C1x C    24.3600  -18.4800
            4   O2x O    23.1000  -19.1100
            5   C1z C    23.3100  -20.5100
            6   O2x O    24.7100  -20.7200
            7   C1a C    23.3100  -21.9100
            8   C1a C    21.9100  -20.5100
            9   C8x C    32.6200  -16.6600
            10  C8x C    32.6200  -15.2600
            11  C8y C    31.3600  -17.3600
            12  C8y C    31.3600  -14.5600
            13  C8x C    30.1700  -16.6600
            14  C8x C    30.1700  -15.2600
            15  O2a O    31.3600  -13.1600
            16  C1b C    32.6200  -12.4600
            17  C1c C    33.8100  -13.1600
            18  C1b C    35.0000  -12.4600
            19  N1b N    36.2600  -13.1600
            20  C1b C    37.4500  -12.4600
            21  C1b C    38.6400  -13.1600
            22  O1a O    33.8100  -14.5600
            23  N1b N    39.8300  -12.4600
            24  C5a C    41.0900  -13.1600
            25  O5a O    42.2800  -12.4600
            26  N1y N    41.0900  -14.5600
            27  C1b C    31.3600  -18.7600
            28  C1x C    39.8300  -15.2600
            29  C1x C    39.8300  -16.6600
            30  O2x O    41.0900  -17.3600
            31  C1x C    42.2800  -16.6600
            32  C1x C    42.2800  -15.2600
            33  C1b C    30.1700  -19.4600
            34  C7a C    28.9800  -18.7600
            35  O7a O    27.7200  -19.4600
            36  C1b C    26.5300  -18.7600
            37  O6a O    28.9800  -17.3600
BOND        38
            1     4   5 1
            2     5   6 1
            3     6   2 1
            4    19  20 1
            5    13  14 1
            6    20  21 1
            7    21  23 1
            8    17  22 1 #Down
            9    12  15 1
            10    9  10 2
            11   15  16 1
            12   23  24 1
            13   24  25 2
            14    9  11 1
            15   24  26 1
            16   16  17 1
            17   11  27 1
            18   10  12 1
            19   17  18 1
            20   11  13 2
            21   18  19 1
            22   12  14 2
            23   26  28 1
            24   28  29 1
            25   29  30 1
            26   30  31 1
            27   31  32 1
            28   32  26 1
            29    5   7 1
            30   27  33 1
            31   33  34 1
            32    5   8 1
            33   34  35 1
            34    2   3 1
            35   35  36 1
            36    3   4 1
            37   34  37 2
            38    2  36 1 #Up

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