KEGG   DRUG: D01847Help
Entry
D01847                      Drug                                   

Name
Landiolol hydrochloride (JAN);
ONO 1101 hydrochloride;
Onoact (TN)
Formula
C25H39N3O8. HCl
Exact mass
545.2504
Mol weight
546.0534
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Therapeutic category: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D01847  Landiolol hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Landiolol
      D01847  Landiolol hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
144481-98-1
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        37
            1   X   Cl   33.6000  -21.0700
            2   C1y C    25.3400  -19.4600
            3   C1x C    24.3600  -18.4800
            4   O2x O    23.1000  -19.1100
            5   C1z C    23.3100  -20.5100
            6   O2x O    24.7100  -20.7200
            7   C1a C    23.3100  -21.9100
            8   C1a C    21.9100  -20.5100
            9   C8x C    32.6200  -16.6600
            10  C8x C    32.6200  -15.2600
            11  C8y C    31.3600  -17.3600
            12  C8y C    31.3600  -14.5600
            13  C8x C    30.1700  -16.6600
            14  C8x C    30.1700  -15.2600
            15  O2a O    31.3600  -13.1600
            16  C1b C    32.6200  -12.4600
            17  C1c C    33.8100  -13.1600
            18  C1b C    35.0000  -12.4600
            19  N1b N    36.2600  -13.1600
            20  C1b C    37.4500  -12.4600
            21  C1b C    38.6400  -13.1600
            22  O1a O    33.8100  -14.5600
            23  N1b N    39.8300  -12.4600
            24  C5a C    41.0900  -13.1600
            25  O5a O    42.2800  -12.4600
            26  N1y N    41.0900  -14.5600
            27  C1b C    31.3600  -18.7600
            28  C1x C    39.8300  -15.2600
            29  C1x C    39.8300  -16.6600
            30  O2x O    41.0900  -17.3600
            31  C1x C    42.2800  -16.6600
            32  C1x C    42.2800  -15.2600
            33  C1b C    30.1700  -19.4600
            34  C7a C    28.9800  -18.7600
            35  O7a O    27.7200  -19.4600
            36  C1b C    26.5300  -18.7600
            37  O6a O    28.9800  -17.3600
BOND        38
            1     4   5 1
            2     5   6 1
            3     6   2 1
            4    19  20 1
            5    13  14 1
            6    20  21 1
            7    21  23 1
            8    17  22 1 #Down
            9    12  15 1
            10    9  10 2
            11   15  16 1
            12   23  24 1
            13   24  25 2
            14    9  11 1
            15   24  26 1
            16   16  17 1
            17   11  27 1
            18   10  12 1
            19   17  18 1
            20   11  13 2
            21   18  19 1
            22   12  14 2
            23   26  28 1
            24   28  29 1
            25   29  30 1
            26   30  31 1
            27   31  32 1
            28   32  26 1
            29    5   7 1
            30   27  33 1
            31   33  34 1
            32    5   8 1
            33   34  35 1
            34    2   3 1
            35   35  36 1
            36    3   4 1
            37   34  37 2
            38    2  36 1 #Up

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