KEGG   DRUG: D01862Help
Entry
D01862                      Drug                                   

Name
Pitavastatin calcium (JAN);
NK 104;
Livalo (TN)
Product
Formula
(C25H23FNO4)2. Ca
Exact mass
880.2848
Mol weight
880.9836
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihyperlipidemic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234]
Interaction
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA08 Pitavastatin
      D01862  Pitavastatin calcium (JAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Pitavastatin
    D01862  Pitavastatin calcium (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D01862  Pitavastatin calcium (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Pitavastatin
     D01862  Pitavastatin calcium (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Pitavastatin
    D01862  Pitavastatin calcium (JAN)
BRITE hierarchy
Other DBs
CAS: 
147526-32-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        63
            1   Z   Ca   38.8500  -13.7900 #2+
            2   C8x C    22.4000  -15.1200
            3   C8x C    22.4000  -16.5200
            4   C8x C    23.5900  -17.2200
            5   C8y C    24.8500  -16.5200
            6   C8y C    24.8500  -15.1200
            7   C8x C    23.5900  -14.4200
            8   N5x N    26.0400  -17.2200
            9   C8y C    27.2300  -16.5200
            10  C8y C    27.2300  -15.1200
            11  C8y C    26.0400  -14.4200
            12  C8y C    26.0400  -13.0200
            13  C8x C    27.2300  -12.3200
            14  C8x C    27.2300  -10.9200
            15  C8y C    26.0400  -10.2200
            16  C8x C    24.8500  -10.9200
            17  C8x C    24.8500  -12.3200
            18  C2b C    28.4200  -14.4200
            19  C2b C    29.6100  -15.1200
            20  X   F    26.0400   -8.8200
            21  C1y C    28.4200  -17.2200
            22  C1c C    30.8000  -14.4200
            23  C1b C    31.9900  -15.1200
            24  C1c C    33.1800  -14.4200
            25  C1b C    34.3700  -15.1200
            26  O1a O    30.8000  -13.0200
            27  O1a O    33.1800  -13.0200
            28  C6a C    35.5600  -14.4200
            29  O6a O    36.7500  -15.1200 #-
            30  O6a O    35.5600  -13.0200
            31  C1x C    29.8200  -17.2200
            32  C1x C    29.1200  -18.4100
            33  C8x C    22.4000  -15.1200
            34  C8x C    22.4000  -16.5200
            35  C8x C    23.5900  -17.2200
            36  C8y C    24.8500  -16.5200
            37  C8y C    24.8500  -15.1200
            38  C8x C    23.5900  -14.4200
            39  C8y C    26.0400  -14.4200
            40  C8y C    27.2300  -15.1200
            41  C8y C    27.2300  -16.5200
            42  N5x N    26.0400  -17.2200
            43  C1y C    28.4200  -17.2200
            44  C1x C    29.1200  -18.4100
            45  C1x C    29.8200  -17.2200
            46  C2b C    28.4200  -14.4200
            47  C2b C    29.6100  -15.1200
            48  C1c C    30.8000  -14.4200
            49  C1b C    31.9900  -15.1200
            50  C1c C    33.1800  -14.4200
            51  C1b C    34.3700  -15.1200
            52  C6a C    35.5600  -14.4200
            53  O6a O    36.7500  -15.1200 #-
            54  O6a O    35.5600  -13.0200
            55  O1a O    33.1800  -13.0200
            56  O1a O    30.8000  -13.0200
            57  C8y C    26.0400  -13.0200
            58  C8x C    27.2300  -12.3200
            59  C8x C    27.2300  -10.9200
            60  C8y C    26.0400  -10.2200
            61  C8x C    24.8500  -10.9200
            62  C8x C    24.8500  -12.3200
            63  X   F    26.0400   -8.8200
BOND        68
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 2
            11    6  11 1
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19   10  18 1
            20   18  19 2
            21   15  20 1
            22    9  21 1
            23   19  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   22  26 1 #Up
            28   24  27 1 #Up
            29   25  28 1
            30   28  29 1
            31   28  30 2
            32   32  31 1
            33   32  21 1
            34   21  31 1
            35   33  34 2
            36   34  35 1
            37   35  36 2
            38   36  37 1
            39   37  38 2
            40   33  38 1
            41   36  42 1
            42   42  41 2
            43   41  40 1
            44   40  39 2
            45   37  39 1
            46   39  57 1
            47   57  58 2
            48   58  59 1
            49   59  60 2
            50   60  61 1
            51   61  62 2
            52   57  62 1
            53   40  46 1
            54   46  47 2
            55   60  63 1
            56   41  43 1
            57   47  48 1
            58   48  49 1
            59   49  50 1
            60   50  51 1
            61   48  56 1 #Up
            62   50  55 1 #Up
            63   51  52 1
            64   52  53 1
            65   52  54 2
            66   44  45 1
            67   44  43 1
            68   43  45 1
BRACKET     1    22.0500  -18.8300   22.0500   -8.4000
            1    37.4500   -8.4000   37.4500  -18.8300
            1  2
 ORIGINAL  1    2   3   4   5   6   7  11  10   9   8  21  32  31  18  19  22
            1   23  24  25  28  29  30  27  26  12  13  14  15  16  17  20
 REPEAT    1   33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48
            1   49  50  51  52  53  54  55  56  57  58  59  60  61  62  63

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