KEGG   DRUG: D01871Help
Entry
D01871                      Drug                                   

Name
Metixene hydrochloride (JAN);
Methixene hydrochloride (USAN);
Methixene hydrochloride hydrete;
Trest (TN)
Formula
C20H23NS. HCl. H2O
Exact mass
363.1424
Mol weight
363.9445
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Relaxant [smooth muscle] [DS:H00057]
Remark
Therapeutic category: 
ATC code: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D01871  Metixene hydrochloride (JAN); Methixene hydrochloride (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA03 Metixene
      D01871  Metixene hydrochloride (JAN); Methixene hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
     Metixene [ATC:N04AA03]
      D01871  Metixene hydrochloride (JAN); Methixene hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
7081-40-5
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        24
            1   C8x C    20.6003  -20.4034
            2   C8x C    20.6003  -21.8048
            3   C8x C    21.8168  -22.5054
            4   C8x C    21.8168  -19.7026
            5   C8y C    23.0265  -20.4034
            6   C8y C    23.0205  -21.8048
            7   S2x S    24.2312  -22.5107
            8   C1y C    24.2430  -19.7079
            9   C8y C    25.4537  -20.4137
            10  C8y C    25.5111  -21.8116
            11  C8x C    26.6451  -22.5212
            12  C8x C    27.8620  -21.8335
            13  C8x C    27.8746  -20.4356
            14  C8x C    26.6704  -19.7259
            15  C1b C    24.2490  -18.3064
            16  C1y C    25.4657  -17.6110
            17  C1x C    26.6716  -18.3176
            18  N1y N    27.8882  -17.6222
            19  C1x C    27.8941  -16.2208
            20  C1x C    26.6835  -15.5148
            21  C1x C    25.4669  -16.2104
            22  C1a C    29.0988  -18.3279
            23  X   Cl   30.3104  -20.0648
            24  O0  O    30.8519  -21.7215
BOND        25
            1     4   1 1
            2     9  10 2
            3    10  11 1
            4    11  12 2
            5    12  13 1
            6    13  14 2
            7    14   9 1
            8     8  15 1
            9     1   2 2
            10   15  16 1
            11    5   6 1
            12    6   7 1
            13    7  10 1
            14    9   8 1
            15    8   5 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   21  16 1
            22    2   3 1
            23   18  22 1
            24    3   6 2
            25    5   4 2

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