KEGG   DRUG: Methixene hydrochlorideHelp
Entry
D01871                      Drug                                   

Name
Methixene hydrochloride (USAN);
Metixene hydrochloride (JAN);
Methixene hydrochloride hydrete;
Trest (TN)
Formula
C20H23NS. HCl. H2O
Exact mass
363.1424
Mol weight
363.9445
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
 DG01745  Anticholinergic antiparkinson agent
Remark
ATC code: 
Chemical group: 
Activity
Antiparkinsonian, Anticholinergic, Smooth muscle relaxant
Target
muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA03 Metixene
      D01871  Methixene hydrochloride (USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Metixene
    D01871  Methixene hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Metixene
      D01871  Methixene hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
7081-40-5
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        24
            1   C8x C    20.6003  -20.4034
            2   C8x C    20.6003  -21.8048
            3   C8x C    21.8168  -22.5054
            4   C8x C    21.8168  -19.7026
            5   C8y C    23.0265  -20.4034
            6   C8y C    23.0205  -21.8048
            7   S2x S    24.2312  -22.5107
            8   C1y C    24.2430  -19.7079
            9   C8y C    25.4537  -20.4137
            10  C8y C    25.5111  -21.8116
            11  C8x C    26.6451  -22.5212
            12  C8x C    27.8620  -21.8335
            13  C8x C    27.8746  -20.4356
            14  C8x C    26.6704  -19.7259
            15  C1b C    24.2490  -18.3064
            16  C1y C    25.4657  -17.6110
            17  C1x C    26.6716  -18.3176
            18  N1y N    27.8882  -17.6222
            19  C1x C    27.8941  -16.2208
            20  C1x C    26.6835  -15.5148
            21  C1x C    25.4669  -16.2104
            22  C1a C    29.0988  -18.3279
            23  X   Cl   30.3104  -20.0648
            24  O0  O    30.8519  -21.7215
BOND        25
            1     4   1 1
            2     9  10 2
            3    10  11 1
            4    11  12 2
            5    12  13 1
            6    13  14 2
            7    14   9 1
            8     8  15 1
            9     1   2 2
            10   15  16 1
            11    5   6 1
            12    6   7 1
            13    7  10 1
            14    9   8 1
            15    8   5 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   21  16 1
            22    2   3 1
            23   18  22 1
            24    3   6 2
            25    5   4 2

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