KEGG   DRUG: MefrusideHelp
Entry
D01877                      Drug                                   

Name
Mefruside (JP17/USAN/INN);
Baycaron (TN)
Formula
C13H19ClN2O5S2
Exact mass
382.0424
Mol weight
382.8834
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
Remark
Therapeutic category: 
ATC code: 
Activity
Diuretic, Na+-Cl- symport inhibitor
Comment
Chlorbenzene sulfonamide derivative
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA05 Mefruside
      D01877  Mefruside (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2135  Chlorbenzene sulfonamides
     D01877  Mefruside (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3
     Mefruside
      D01877  Mefruside (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01877  Mefruside
  D01877  Mefruside tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D01877
BRITE hierarchy
Other DBs
CAS: 
7195-27-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    19.7400  -16.0300
            2   S4a S    18.5500  -15.3300
            3   N1c N    17.3600  -16.0300
            4   O3c O    19.7400  -14.6300
            5   O3c O    17.3600  -14.6300
            6   C1b C    16.1700  -15.3300
            7   C1a C    17.3600  -17.4300
            8   C1z C    14.9100  -16.0300
            9   C1x C    13.6500  -15.4700
            10  C1x C    12.7400  -16.4500
            11  C1x C    13.4400  -17.7100
            12  O2x O    14.9100  -17.4300
            13  C1a C    14.9100  -14.6300
            14  C8x C    20.9300  -15.3300
            15  C8x C    19.7400  -17.4300
            16  C8y C    22.1200  -16.0300
            17  C8x C    20.9300  -18.1300
            18  C8y C    22.1200  -17.4300
            19  S4a S    23.3100  -15.4000
            20  X   Cl   23.3100  -18.1300
            21  O3c O    22.5400  -14.2800
            22  O3c O    24.2200  -16.6600
            23  N1a N    24.5700  -14.7000
BOND        24
            1    11  12 1
            2    12   8 1
            3     1   2 1
            4     8  13 1
            5     3   7 1
            6     2   4 2
            7     6   8 1
            8     2   5 2
            9     2   3 1
            10    3   6 1
            11    8   9 1
            12    9  10 1
            13   10  11 1
            14    1  14 1
            15    1  15 2
            16   14  16 2
            17   15  17 1
            18   16  18 1
            19   16  19 1
            20   18  20 1
            21   19  21 2
            22   19  22 2
            23   19  23 1
            24   17  18 2

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