KEGG   DRUG: CilostazolHelp
Entry
D01896                      Drug                                   

Name
Cilostazol (JP17/USAN/INN);
Pletal (TN)
Product
  Generic
CILOSTAZOL (American Health Packaging), CILOSTAZOL (Apotex Corp.), CILOSTAZOL (AvPAK), CILOSTAZOL (Avera McKennan Hospital), CILOSTAZOL (Avera McKennan Hospital), CILOSTAZOL (BioKey), CILOSTAZOL (Breckenridge Pharmaceutical), CILOSTAZOL (Bryant Ranch Prepack), CILOSTAZOL (Bryant Ranch Prepack), CILOSTAZOL (Cardinal Health), CILOSTAZOL (Cardinal Health), CILOSTAZOL (Carilion Materials Management), CILOSTAZOL (Carilion Materials Management), CILOSTAZOL (Eon Labs), CILOSTAZOL (Golden State Medical Supply), CILOSTAZOL (Golden State Medical Supply), CILOSTAZOL (Lake Erie Medical DBA Quality Care Products LLC), CILOSTAZOL (Lake Erie Medical DBA Quality Care Products LLC), CILOSTAZOL (NCS HealthCare of KY), CILOSTAZOL (NCS HealthCare of KY), CILOSTAZOL (Physicians Total Care), CILOSTAZOL (Preferred Pharmaceuticals), CILOSTAZOL (STAT RX USA LLC), CILOSTAZOL (Teva Pharmaceuticals USA), CILOSTAZOL (West-Ward Pharmaceuticals Corp.)
Formula
C20H27N5O2
Exact mass
369.2165
Mol weight
369.4607
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01507  Phosphodiesterase III inhibitor
 DG01712  Antiplatelet agent
  DG01712  Antiplatelet agent
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Therapeutic category: 
ATC code: 
Activity
Vasodilator, Platelet aggregation inhibitor, Phosphodiesterase inhibitor
Target
PDE3 [HSA:5139 5140] [KO:K19021 K13296];
adenosine uptake
  Pathway
Purine metabolism
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC23 Cilostazol
      D01896  Cilostazol (JP17/USAN/INN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Platelet Modifying Agents
   Cilostazol
    D01896  Cilostazol (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D01896  Cilostazol (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   phosphodiesterase (PDE) III
    Cilostazol
     D01896  Cilostazol (JP17/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP3A
   Cilostazol
    D01896  Cilostazol (JP17/USAN/INN)
 CYP substrates
  CYP2C19
   Cilostazol
    D01896  Cilostazol (JP17/USAN/INN)
  CYP2D6
   Cilostazol
    D01896  Cilostazol (JP17/USAN/INN)
  CYP3A4
   Cilostazol
    D01896  Cilostazol (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01896  Cilostazol
  D01896  Cilostazol tablets
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01896
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01896
BRITE hierarchy
Other DBs
CAS: 
73963-72-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C1y C    21.6291  -13.6161
            2   C1x C    21.6291  -15.0158
            3   C1x C    20.4140  -15.7157
            4   C1x C    19.2060  -15.0158
            5   C1x C    19.2060  -13.6161
            6   C1x C    20.4140  -12.9162
            7   N4y N    22.8410  -12.9155
            8   C8y C    22.8310  -11.5237
            9   N5x N    24.1537  -11.0795
            10  N5x N    24.9846  -12.2002
            11  N5x N    24.1756  -13.3370
            12  C8y C    13.1531  -11.4954
            13  C8y C    13.1600  -12.9021
            14  N1x N    11.9445  -13.6081
            15  C5x C    10.7217  -12.9144
            16  C1x C    10.7146  -11.5078
            17  C1x C    11.9303  -10.7947
            18  C8y C    15.5755  -11.5086
            19  C8x C    15.5771  -12.9086
            20  C8x C    14.3572  -13.6076
            21  C8x C    14.3592  -10.7940
            22  O5x O     9.5059  -13.6203
            23  O2a O    16.7868  -10.8096
            24  C1b C    17.9956  -11.5095
            25  C1b C    19.2045  -10.8167
            26  C1b C    20.4133  -11.5166
            27  C1b C    21.6222  -10.8239
BOND        30
            1     1   7 1
            2     1   2 1
            3     2   3 1
            4     3   4 1
            5     4   5 1
            6     7   8 1
            7     8   9 2
            8     9  10 1
            9    13  14 1
            10   18  19 1
            11   19  20 2
            12   20  13 1
            13   12  21 1
            14   21  18 2
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  12 1
            19   12  13 2
            20   15  22 2
            21   10  11 2
            22   18  23 1
            23   11   7 1
            24   23  24 1
            25    5   6 1
            26   24  25 1
            27    6   1 1
            28   25  26 1
            29   26  27 1
            30   27   8 1

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