KEGG   DRUG: D01896Help
Entry
D01896                      Drug                                   

Name
Cilostazol (JP16/USAN/INN);
Pletal (TN)
Product
  Generic
Formula
C20H27N5O2
Exact mass
369.2165
Mol weight
369.4607
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator;
Inhibitor [platelet];
Antithrombotic
Remark
Therapeutic category: 
ATC code: 
Target
phosphodiesterase III inhibitor [HSA:5139 5140] [KO:K13296];
adenosine uptake inhibitor
  Pathway
hsa00230  Purine metabolism
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antithrombosis agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D01896  Cilostazol (JP16/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC23 Cilostazol
      D01896  Cilostazol (JP16/USAN/INN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Platelet Modifying Agents
   Cilostazol
    D01896  Cilostazol (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   phosphodiesterase (PDE) III [HSA:5139 5140] [KO:K13296]
    Cilostazol [ATC:B01AC23]
     D01896  Cilostazol (JP16/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
73963-72-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C1y C    21.6291  -13.6161
            2   C1x C    21.6291  -15.0158
            3   C1x C    20.4140  -15.7157
            4   C1x C    19.2060  -15.0158
            5   C1x C    19.2060  -13.6161
            6   C1x C    20.4140  -12.9162
            7   N4y N    22.8410  -12.9155
            8   C8y C    22.8310  -11.5237
            9   N5x N    24.1537  -11.0795
            10  N5x N    24.9846  -12.2002
            11  N5x N    24.1756  -13.3370
            12  C8y C    13.1531  -11.4954
            13  C8y C    13.1600  -12.9021
            14  N1x N    11.9445  -13.6081
            15  C5x C    10.7217  -12.9144
            16  C1x C    10.7146  -11.5078
            17  C1x C    11.9303  -10.7947
            18  C8y C    15.5755  -11.5086
            19  C8x C    15.5771  -12.9086
            20  C8x C    14.3572  -13.6076
            21  C8x C    14.3592  -10.7940
            22  O5x O     9.5059  -13.6203
            23  O2a O    16.7868  -10.8096
            24  C1b C    17.9956  -11.5095
            25  C1b C    19.2045  -10.8167
            26  C1b C    20.4133  -11.5166
            27  C1b C    21.6222  -10.8239
BOND        30
            1     1   7 1
            2     1   2 1
            3     2   3 1
            4     3   4 1
            5     4   5 1
            6     7   8 1
            7     8   9 2
            8     9  10 1
            9    13  14 1
            10   18  19 1
            11   19  20 2
            12   20  13 1
            13   12  21 1
            14   21  18 2
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  12 1
            19   12  13 2
            20   15  22 2
            21   10  11 2
            22   18  23 1
            23   11   7 1
            24   23  24 1
            25    5   6 1
            26   24  25 1
            27    6   1 1
            28   25  26 1
            29   26  27 1
            30   27   8 1

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