KEGG   DRUG: D01897Help
Entry
D01897                      Drug                                   

Name
Rokitamycin (JP16/INN);
RKM;
Ricamycin (TN)
Formula
C42H69NO15
Exact mass
827.4667
Mol weight
827.995
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
0 Mak  1 Mad  2 Mad  3 Mak  4 Mte  5 Etk  6 Mxk  7 Man
  Type
PK
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Comment
Semisynthetic macrolide
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Macrolides and ketolides
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6149  Others
     D01897  Rokitamycin (JP16/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA12 Rokitamycin
      D01897  Rokitamycin (JP16/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Rokitamycin [ATC:J01FA12]
      D01897  Rokitamycin (JP16/INN)
BRITE hierarchy
Other DBs
CAS: 
74014-51-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        58
            1   O7a O    25.9369  -25.6342
            2   C7a C    27.2859  -25.6342
            3   C1y C    28.5011  -20.9120
            4   C1y C    29.6079  -21.5593
            5   O2a O    27.3989  -21.5593
            6   C1y C    28.5011  -19.6406
            7   C1y C    30.7267  -20.9120
            8   N1c N    29.6079  -22.8376
            9   C1y C    26.1580  -22.1956
            10  O2x O    29.6079  -19.0042
            11  C1a C    27.4046  -19.0042
            12  C1y C    30.7267  -19.6406
            13  O1a O    31.8346  -21.5593
            14  C1a C    30.7154  -23.4727
            15  C1a C    28.5068  -23.4727
            16  C1x C    26.1580  -23.4670
            17  O2x O    25.0389  -21.5593
            18  O2a O    32.3987  -17.4593
            19  C1z C    25.0389  -24.1144
            20  C1y C    23.9322  -22.1956
            21  C1y C    29.5461  -14.9226
            22  C1y C    23.9322  -23.4670
            23  C1a C    24.1760  -25.4751
            24  C1a C    22.8358  -21.3493
            25  C1y C    29.5405  -13.6106
            26  C1y C    28.4159  -15.5872
            27  O7a O    22.6958  -24.3944
            28  C1x C    28.3989  -12.9688
            29  C1b C    30.6357  -12.9631
            30  C1y C    28.4215  -16.9671
            31  O2a O    27.4424  -15.0264
            32  C1y C    28.3989  -11.6806
            33  C4a C    31.7492  -13.5938
            34  C1x C    27.2799  -17.5578
            35  C1y C    27.2742  -11.0443
            36  C1a C    29.5000  -11.0388
            37  O4a O    32.8503  -12.9463
            38  C7x C    26.1212  -16.9159
            39  C2x C    26.1732  -11.6806
            40  O1a O    27.2742   -9.7737
            41  O7x O    24.9639  -17.5523
            42  O6a O    26.1212  -15.6379
            43  C2x C    26.1732  -12.9688
            44  C1y C    23.8223  -16.8584
            45  C2x C    24.9962  -13.6106
            46  C1x C    23.8055  -15.5068
            47  C1a C    22.6977  -17.4720
            48  C2x C    24.9559  -14.9056
            49  C1a C    27.4321  -13.8242
            50  C7a C    21.5933  -23.7689
            51  C1b C    20.4967  -24.4163
            52  O6a O    21.5572  -22.5494
            53  O1a O    29.5835  -17.6368
            54  C1b C    19.3877  -23.7903
            55  O6a O    27.9605  -26.8026
            56  C1b C    27.9605  -24.4659
            57  C1a C    29.3096  -24.4659
            58  C1a C    18.2911  -24.4380
BOND        60
            1    19   1 1 #Up
            2    20  24 1 #Down
            3    21  25 1
            4    21  26 1
            5    22  27 1 #Up
            6    25  28 1
            7    25  29 1 #Down
            8    26  30 1
            9    26  31 1 #Down
            10   28  32 1
            11   29  33 1
            12   30  34 1
            13   32  35 1
            14   32  36 1 #Down
            15   33  37 2
            16   34  38 1
            17   35  39 1
            18   35  40 1 #Down
            19   38  41 1
            20   38  42 2
            21   39  43 2
            22   41  44 1
            23   43  45 1
            24   44  46 1
            25   44  47 1 #Down
            26   45  48 2
            27   10  12 1
            28   20  22 1
            29   46  48 1
            30   31  49 1
            31    3   4 1
            32   27  50 1
            33    3   5 1 #Down
            34   50  51 1
            35    3   6 1
            36   50  52 2
            37    4   7 1
            38    4   8 1 #Up
            39    9   5 1 #Up
            40    6  10 1
            41    6  11 1 #Up
            42    7  12 1
            43    7  13 1 #Down
            44    8  14 1
            45   30  53 1 #Down
            46    8  15 1
            47    9  16 1
            48    9  17 1
            49    1   2 1
            50   12  18 1 #Up
            51   16  19 1
            52   17  20 1
            53   51  54 1
            54   21  18 1 #Down
            55    2  55 2
            56   19  22 1
            57    2  56 1
            58   56  57 1
            59   19  23 1 #Down
            60   54  58 1

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