KEGG   DRUG: D01898Help
Entry
D01898                      Drug                                   

Name
Haloperidol decanoate (JAN/USAN);
Halomonth (TN)
Product
  Generic
Formula
C31H41ClFNO3
Exact mass
529.2759
Mol weight
530.1135
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
Therapeutic category: 
ATC code: 
Comment
prodrug, active substance: Haloperidol [DR:D00136]
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Butyrophenones
Dopamine receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01898  Haloperidol decanoate (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD01 Haloperidol
      D01898  Haloperidol decanoate (JAN/USAN)
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Haloperidol
    D01898  Haloperidol decanoate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Haloperidol [ATC:N05AD01]
      D01898  Haloperidol decanoate (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
74050-97-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        37
            1   C1b C    16.3100  -17.5700
            2   C1b C    17.5000  -16.8700
            3   C1b C    18.6900  -17.5700
            4   N1y N    19.9500  -16.8700
            5   C1x C    19.9500  -15.4700
            6   C1x C    21.1400  -17.5700
            7   C1x C    21.1400  -14.7700
            8   C1x C    22.3300  -16.8700
            9   C1z C    22.3300  -15.4700
            10  C8y C    23.5900  -14.7700
            11  C8x C    23.5900  -13.4400
            12  C8x C    24.7800  -15.4700
            13  C8x C    24.7800  -12.7400
            14  C8x C    25.9700  -14.8400
            15  C8y C    25.9700  -13.4400
            16  X   Cl   27.1600  -12.7400
            17  C5a C    15.0500  -16.8700
            18  C8y C    13.7900  -17.5700
            19  O5a O    15.0500  -15.4000
            20  C8x C    13.7900  -18.9700
            21  C8x C    12.6000  -19.6700
            22  C8y C    11.3400  -18.9700
            23  C8x C    11.3400  -17.5700
            24  C8x C    12.6000  -16.8700
            25  X   F    10.0800  -19.6700
            26  O7a O    23.5200  -16.1700
            27  C7a C    23.5200  -17.5700
            28  C1b C    24.7100  -18.2700
            29  O6a O    22.2600  -18.2700
            30  C1b C    25.9000  -17.6400
            31  C1b C    27.0900  -18.2700
            32  C1b C    28.2800  -17.6400
            33  C1b C    29.4700  -18.2700
            34  C1b C    30.8000  -17.6400
            35  C1b C    31.9900  -18.2700
            36  C1b C    33.1800  -17.6400
            37  C1a C    34.3700  -18.2700
BOND        39
            1     1  17 1
            2     1   2 1
            3    17  18 1
            4     2   3 1
            5    17  19 2
            6     3   4 1
            7     4   5 1
            8     4   6 1
            9     5   7 1
            10    6   8 1
            11   18  20 1
            12   20  21 2
            13   21  22 1
            14   22  23 2
            15   23  24 1
            16   24  18 2
            17    7   9 1
            18   22  25 1
            19    9  10 1
            20   10  11 1
            21   10  12 2
            22   11  13 2
            23   12  14 1
            24   13  15 1
            25   15  16 1
            26    8   9 1
            27   14  15 2
            28    9  26 1
            29   26  27 1
            30   27  28 1
            31   27  29 2
            32   28  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   35  36 1
            39   36  37 1

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