KEGG   DRUG: D01902Help
Entry
D01902                      Drug                                   

Name
Dimetotiazine mesilate (JAN);
Fonazine mesylate (USAN);
Banistyl (TN)
Formula
C19H25N3O2S2. CH4SO3
Exact mass
487.1269
Mol weight
487.6564
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Serotonin inhibitor
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
histamine H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Interaction
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX05 Dimetotiazine
      D01902  Dimetotiazine mesilate (JAN); Fonazine mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01902  Dimetotiazine mesilate (JAN); Fonazine mesylate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dimetotiazine
      D01902  Dimetotiazine mesilate (JAN); Fonazine mesylate (USAN)
   Serotonin
    5-HT2-receptor
     Dimetotiazine
      D01902  Dimetotiazine mesilate (JAN); Fonazine mesylate (USAN)
BRITE hierarchy
Other DBs
CAS: 
7455-39-2
PubChem: 
LigandBox: 
KCF data Show

ATOM        31
            1   S2x S    20.7043  -19.6995
            2   N1y N    20.7043  -16.8964
            3   C8y C    21.9139  -17.5972
            4   C8y C    21.9080  -18.9987
            5   C8x C    23.1187  -19.7046
            6   C8x C    24.3354  -19.0091
            7   C8y C    24.3415  -17.6076
            8   C8x C    23.1307  -16.9017
            9   C8y C    19.4876  -18.9987
            10  C8y C    19.4876  -17.5972
            11  C8x C    18.2739  -16.8964
            12  C8x C    17.0601  -17.5972
            13  C8x C    17.0601  -18.9987
            14  C8x C    18.2739  -19.6995
            15  C1b C    20.7062  -15.4949
            16  C1c C    21.9209  -14.7957
            17  C1a C    23.1338  -15.4979
            18  N1c N    21.9226  -13.3941
            19  C1a C    23.1372  -12.6948
            20  C1a C    20.7097  -12.6918
            21  S4a S    25.5565  -16.9131
            22  N1c N    26.7726  -17.6220
            23  O1d O    26.5300  -15.9600
            24  O1d O    24.5700  -15.9600
            25  C1a C    27.9556  -16.9455
            26  C1a C    26.7671  -19.0397
            27  S4a S    33.5466  -16.9222
            28  O1d O    33.5302  -15.5676
            29  O1d O    33.5068  -18.3236
            30  C1a C    32.1452  -16.9222
            31  O1d O    34.9479  -16.9222
BOND        32
            1     1   4 1
            2     9  10 2
            3    10  11 1
            4    11  12 2
            5    12  13 1
            6    13  14 2
            7    14   9 1
            8     3   2 1
            9     2  15 1
            10    3   4 2
            11   15  16 1
            12    4   5 1
            13    5   6 2
            14   16  17 1
            15   16  18 1
            16    6   7 1
            17   18  19 1
            18    7   8 2
            19   18  20 1
            20    8   3 1
            21    2  10 1
            22    9   1 1
            23    7  21 1
            24   21  22 1
            25   21  23 2
            26   21  24 2
            27   22  25 1
            28   22  26 1
            29   27  28 2
            30   27  29 2
            31   27  30 1
            32   27  31 1

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