KEGG   DRUG: NilvadipineHelp
Entry
D01908                      Drug                                   

Name
Nilvadipine (JP17/USAN/INN);
Nivadil (TN)
Formula
C19H19N3O6
Exact mass
385.1274
Mol weight
385.3707
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA10 Nilvadipine
      D01908  Nilvadipine (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01908  Nilvadipine (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Nilvadipine
      D01908  Nilvadipine (JP17/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Nilvadipine
    D01908  Nilvadipine (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01908  Nilvadipine
  D01908  Nilvadipine tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D01908
BRITE hierarchy
Other DBs
CAS: 
75530-68-6
PubChem: 
ChEBI: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1y C    25.7019  -15.9679
            2   C2y C    26.8926  -15.2676
            3   C2y C    24.4413  -15.2676
            4   C8y C    25.7019  -17.3687
            5   C2y C    26.8926  -13.8668
            6   C7a C    28.0832  -15.9679
            7   C2y C    24.4413  -13.8668
            8   C7a C    23.2507  -15.9679
            9   C8x C    26.8926  -18.0690
            10  C8x C    24.5113  -18.0690
            11  N1x N    25.7019  -13.1665
            12  C3b C    28.0832  -13.1665
            13  O7a O    29.3439  -15.2676
            14  O6a O    28.0832  -17.3687
            15  C1a C    23.2507  -13.1665
            16  O7a O    22.0600  -15.2676
            17  O6a O    23.2507  -17.3687
            18  C8y C    26.8926  -19.4698
            19  C8x C    24.5113  -19.4698
            20  C1a C    30.5345  -15.9679
            21  C1c C    20.7994  -15.9679
            22  C8x C    25.7019  -20.1701
            23  N2b N    28.1532  -20.1701 #+
            24  O3a O    29.6239  -19.2598
            25  O3a O    28.1532  -21.5709 #-
            26  C1a C    20.7994  -17.3687
            27  C1a C    19.6087  -15.2676
            28  N3a N    29.3439  -12.4661
BOND        29
            1     1   4 1
            2     2   5 2
            3     2   6 1
            4     3   7 2
            5     3   8 1
            6     4   9 1
            7     4  10 2
            8     5  11 1
            9     5  12 1
            10    6  13 1
            11    6  14 2
            12    7  15 1
            13    8  16 1
            14    8  17 2
            15    9  18 2
            16   10  19 1
            17   13  20 1
            18   16  21 1
            19   18  22 1
            20   18  23 1
            21   23  24 2
            22   23  25 1
            23    7  11 1
            24   19  22 2
            25   21  26 1
            26    1   2 1
            27   21  27 1
            28    1   3 1
            29   12  28 3

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