KEGG   DRUG: D01908Help
Entry
D01908                      Drug                                   

Name
Nilvadipine (JP16/USAN/INN);
Nivadil (TN)
Formula
C19H19N3O6
Exact mass
385.1274
Mol weight
385.3707
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antagonist [calcium channnel]
Remark
Therapeutic category: 
ATC code: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA10 Nilvadipine
      D01908  Nilvadipine (JP16/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01908  Nilvadipine (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Nilvadipine
      D01908  Nilvadipine (JP16/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Nilvadipine
    D01908  Nilvadipine (JP16/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01908  Nilvadipine
  D01908  Nilvadipine tablets
BRITE hierarchy
Other DBs
CAS: 
75530-68-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1y C    25.7019  -15.9679
            2   C2y C    26.8926  -15.2676
            3   C2y C    24.4413  -15.2676
            4   C8y C    25.7019  -17.3687
            5   C2y C    26.8926  -13.8668
            6   C7a C    28.0832  -15.9679
            7   C2y C    24.4413  -13.8668
            8   C7a C    23.2507  -15.9679
            9   C8x C    26.8926  -18.0690
            10  C8x C    24.5113  -18.0690
            11  N1x N    25.7019  -13.1665
            12  C3b C    28.0832  -13.1665
            13  O7a O    29.3439  -15.2676
            14  O6a O    28.0832  -17.3687
            15  C1a C    23.2507  -13.1665
            16  O7a O    22.0600  -15.2676
            17  O6a O    23.2507  -17.3687
            18  C8y C    26.8926  -19.4698
            19  C8x C    24.5113  -19.4698
            20  C1a C    30.5345  -15.9679
            21  C1c C    20.7994  -15.9679
            22  C8x C    25.7019  -20.1701
            23  N2b N    28.1532  -20.1701 #+
            24  O3a O    29.6239  -19.2598
            25  O3a O    28.1532  -21.5709 #-
            26  C1a C    20.7994  -17.3687
            27  C1a C    19.6087  -15.2676
            28  N3a N    29.3439  -12.4661
BOND        29
            1     1   4 1
            2     2   5 2
            3     2   6 1
            4     3   7 2
            5     3   8 1
            6     4   9 1
            7     4  10 2
            8     5  11 1
            9     5  12 1
            10    6  13 1
            11    6  14 2
            12    7  15 1
            13    8  16 1
            14    8  17 2
            15    9  18 2
            16   10  19 1
            17   13  20 1
            18   16  21 1
            19   18  22 1
            20   18  23 1
            21   23  24 2
            22   23  25 1
            23    7  11 1
            24   19  22 2
            25   21  26 1
            26    1   2 1
            27   21  27 1
            28    1   3 1
            29   12  28 3

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