| Entry |
|
|---|
| Name |
Rosuvastatin calcium (JAN/USAN);
ZD 4522;
Crestor (TN)
|
|---|
| Product |
CRESTOR (A-S Medication Solutions LLC), CRESTOR (AstraZeneca Pharmaceuticals LP), CRESTOR (Bryant Ranch Prepack), CRESTOR (Bryant Ranch Prepack), CRESTOR (Cardinal Health), CRESTOR (H.J. Harkins Company), CRESTOR (Lake Erie Medical & Surgucal Supply DBA Quality Care Products LLC), CRESTOR (Lake Erie Medical DBA Quality Care Products LLC), CRESTOR (PD-Rx Pharmaceuticals), CRESTOR (PD-Rx Pharmaceuticals), CRESTOR (Physicians Total Care), CRESTOR (REMEDYREPACK), CRESTOR (Rebel Distributors Corp) |
|---|
| Formula |
(C22H27FN3O6S)2. Ca
|
|---|
| Exact mass |
1000.2835
|
|---|
| Mol weight |
1001.1374
|
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| Structure |
     |
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| Activity |
Antihyperlipidemic [HMGCoA reductase inhibitor]
|
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| Remark |
Therapeutic category: ATC code: |
|---|
| Target |
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor [HSA: 3156] [KO: K00021] |
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| Pathway |
hsa00900 Terpenoid backbone biosynthesis | |
|
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| Metabolism |
Transporter: ABCG2 [HSA: 9429], SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234], SLC22A8 [HSA: 9376]
|
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| Interaction |
|
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| Structure map |
| HMG-CoA reductase inhibitors |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
218 Hyperlipidemia agents
2189 Others
D01915 Rosuvastatin calcium (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA07 Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase [HSA:3156] [KO:K00021]
Rosuvastatin [ATC:C10AA07]
D01915 Rosuvastatin calcium (JAN/USAN)
 |
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| Other DBs |
CAS: 147098-20-2 PubChem: DrugBank: LigandBox: |
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| KCF data |
ATOM 67
1 C8y C 24.4367 -20.6549
2 N5x N 24.4367 -22.0555
3 C8y C 25.6498 -22.7558
4 N5x N 26.8627 -22.0555
5 C8y C 26.8627 -20.6549
6 C8y C 25.6498 -19.9546
7 C1c C 28.0770 -19.9538
8 C1a C 29.2913 -20.6549
9 C1a C 28.0770 -18.5540
10 C2b C 25.6498 -18.5540
11 C2b C 26.8634 -17.8533
12 C1c C 26.8634 -16.4531
13 O1a O 28.0772 -15.7523
14 C1b C 25.6513 -15.7533
15 C1c C 25.6507 -14.3522
16 O1a O 24.4373 -13.6524
17 C1b C 26.8633 -13.6514
18 C6a C 28.2651 -13.6519
19 O6a O 28.9659 -12.4392
20 O6a O 28.9649 -14.8651 #-
21 N1c N 25.6498 -24.1565
22 S4a S 26.8634 -24.8572
23 C1a C 24.4374 -24.8564
24 C1a C 28.0773 -24.1563
25 O3c O 25.8841 -25.8373
26 O3c O 27.8449 -25.8373
27 C8y C 23.2238 -19.9546
28 C8x C 23.2238 -18.5540
29 C8x C 22.0108 -17.8537
30 C8y C 20.7978 -18.5540
31 C8x C 20.7978 -19.9546
32 C8x C 22.0108 -20.6549
33 X F 19.5828 -17.8525
34 Z Ca 33.4941 -14.9124 #2+
35 C8y C 24.4367 -20.6549
36 N5x N 24.4367 -22.0555
37 C8y C 25.6498 -22.7558
38 N5x N 26.8627 -22.0555
39 C8y C 26.8627 -20.6549
40 C8y C 25.6498 -19.9546
41 C2b C 25.6498 -18.5540
42 C2b C 26.8634 -17.8533
43 C1c C 26.8634 -16.4531
44 O1a O 28.0772 -15.7523
45 C1b C 25.6513 -15.7533
46 C1c C 25.6507 -14.3522
47 O1a O 24.4373 -13.6524
48 C1b C 26.8633 -13.6514
49 C6a C 28.2651 -13.6519
50 O6a O 28.9659 -12.4392
51 O6a O 28.9649 -14.8651 #-
52 C1c C 28.0770 -19.9538
53 C1a C 29.2913 -20.6549
54 C1a C 28.0770 -18.5540
55 N1c N 25.6498 -24.1565
56 S4a S 26.8634 -24.8572
57 C1a C 28.0773 -24.1563
58 O3c O 25.8841 -25.8373
59 O3c O 27.8449 -25.8373
60 C1a C 24.4374 -24.8564
61 C8y C 23.2238 -19.9546
62 C8x C 23.2238 -18.5540
63 C8x C 22.0108 -17.8537
64 C8y C 20.7978 -18.5540
65 C8x C 20.7978 -19.9546
66 C8x C 22.0108 -20.6549
67 X F 19.5828 -17.8525
BOND 68
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 7 9 1
10 6 10 1
11 10 11 2
12 12 11 1 #Down
13 12 13 1
14 12 14 1
15 14 15 1
16 15 16 1 #Up
17 15 17 1
18 17 18 1
19 18 19 2
20 18 20 1
21 3 21 1
22 21 22 1
23 21 23 1
24 22 24 1
25 22 25 2
26 22 26 2
27 1 27 1
28 27 28 2
29 28 29 1
30 29 30 2
31 30 31 1
32 31 32 2
33 27 32 1
34 30 33 1
35 35 36 2
36 36 37 1
37 37 38 2
38 38 39 1
39 39 40 2
40 35 40 1
41 39 52 1
42 52 53 1
43 52 54 1
44 40 41 1
45 41 42 2
46 43 42 1 #Down
47 43 44 1
48 43 45 1
49 45 46 1
50 46 47 1 #Up
51 46 48 1
52 48 49 1
53 49 50 2
54 49 51 1
55 37 55 1
56 55 56 1
57 55 60 1
58 56 57 1
59 56 58 2
60 56 59 2
61 35 61 1
62 61 62 2
63 62 63 1
64 63 64 2
65 64 65 1
66 65 66 2
67 61 66 1
68 64 67 1
BRACKET 1 18.4100 -26.5300 18.4100 -11.4100
1 31.4300 -11.4100 31.4300 -26.5300
1 2
ORIGINAL 1 1 2 3 4 5 6 10 11 12 13 14 15 16 17 18 19
1 20 7 8 9 21 22 24 25 26 23 27 28 29 30 31 32
1 33
REPEAT 1 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50
1 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66
1 67
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