KEGG   DRUG: D01939Help
Entry
D01939                      Drug                                   

Name
Ziprasidone hydrochloride hydrate (JAN);
Ziprasidone hydrochloride (USAN);
Geodon (TN)
Product
  Generic
ZIPRASIDONE HYDROCHLORIDE (American Health Packaging), ZIPRASIDONE HYDROCHLORIDE (Apotex Corp.), ZIPRASIDONE HYDROCHLORIDE (Clinical Solutions Wholesale), ZIPRASIDONE HYDROCHLORIDE (Golden State Medical Supply), ZIPRASIDONE HYDROCHLORIDE (American Health Packaging), ZIPRASIDONE HYDROCHLORIDE (BluePoint Laboratories), ZIPRASIDONE HYDROCHLORIDE (Cardinal Health), ZIPRASIDONE HYDROCHLORIDE (Cardinal Health), ZIPRASIDONE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ZIPRASIDONE (Greenstone LLC), ZIPRASIDONE HYDROCHLORIDE (Lupin Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (Major Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (Mylan Institutional), ZIPRASIDONE HYDROCHLORIDE (Mylan Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE (REMEDYREPACK), ZIPRASIDONE (REMEDYREPACK), ZIPRASIDONE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (Rebel Distributors Corp), ZIPRASIDONE HYDROCHLORIDE (Sandoz), ZIPRASIDONE HYDROCHLORIDE (TYA Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (TYA Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (TYA Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (Unit Dose Services), ZIPRASIDONE HYDROCHLORIDE (Wockhardt Limited), ZIPRASIDONE HYDROCHLORIDE (Wockhardt USA LLC.)
Formula
C21H21ClN4OS. HCl. H2O
Exact mass
466.0997
Mol weight
467.4119
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
ATC code: 
Drug group: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AE Indole derivatives
     N05AE04 Ziprasidone
      D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Ziprasidone
    D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
 Bipolar Agents
  Bipolar Agents, Other
   Ziprasidone
    D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Ziprasidone
      D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
   Serotonin
    5-HT2-receptor
     Ziprasidone
      D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Ziprasidone
    D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
  CYP3A5
   Ziprasidone
    D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
  CYP3A7
   Ziprasidone
    D01939  Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
138982-67-9
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        30
            1   X   Cl   31.8552  -16.3528
            2   O0  O    32.0673  -19.1818
            3   C8y C    16.1889  -14.5797
            4   C8y C    14.9309  -15.1854
            5   N1y N    17.3536  -15.2786
            6   N5x N    16.1889  -13.1821
            7   C8y C    13.9992  -14.1139
            8   C8x C    14.5117  -16.4899
            9   C1x C    17.3535  -16.6763
            10  C1x C    18.6115  -14.5797
            11  S2x S    14.6514  -12.9026
            12  C8x C    12.6015  -14.3934
            13  C8x C    13.1605  -16.7695
            14  C1x C    18.5649  -17.3751
            15  C1x C    19.7762  -15.2786
            16  C8x C    12.1822  -15.7911
            17  N1y N    19.7762  -16.6763
            18  C1b C    21.0342  -17.3286
            19  C1b C    22.1523  -16.6297
            20  C8y C    23.3636  -17.2820
            21  C8x C    24.5749  -16.6763
            22  C8y C    23.3636  -18.7262
            23  C8y C    25.7863  -17.3286
            24  C8x C    24.5749  -19.4251
            25  X   Cl   22.1523  -19.4251
            26  C8y C    25.7863  -18.7262
            27  C1x C    27.1374  -16.9092
            28  N1x N    27.0907  -19.1921
            29  C5x C    27.9294  -18.0274
            30  O5x O    29.3270  -18.0273
BOND        32
            1     3   4 1
            2     3   5 1
            3     3   6 2
            4     4   7 2
            5     4   8 1
            6     5   9 1
            7     5  10 1
            8     6  11 1
            9     7  12 1
            10    8  13 2
            11    9  14 1
            12   10  15 1
            13   12  16 2
            14   14  17 1
            15   17  18 1
            16   18  19 1
            17   19  20 1
            18   20  21 2
            19   20  22 1
            20   21  23 1
            21   22  24 2
            22   22  25 1
            23   23  26 2
            24   23  27 1
            25   26  28 1
            26   27  29 1
            27   29  30 2
            28    7  11 1
            29   13  16 1
            30   15  17 1
            31   24  26 1
            32   28  29 1

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