KEGG   DRUG: Ziprasidone hydrochlorideHelp
Entry
D01939                      Drug                                   

Name
Ziprasidone hydrochloride (USAN);
Ziprasidone hydrochloride hydrate (JAN);
Geodon (TN)
Product
  Generic
LISINOPRIL (Unit Dose Services), ZIPRASIDONE (Cadila Healthcare Limited), ZIPRASIDONE (Zydus Pharmaceuticals (USA)), ZIPRASIDONE HYDROCHLORIDE (A-S Medication Solutions), ZIPRASIDONE HYDROCHLORIDE (American Health Packaging), ZIPRASIDONE HYDROCHLORIDE (Apotex Corp.), ZIPRASIDONE HYDROCHLORIDE (Bryant Ranch Prepack), ZIPRASIDONE HYDROCHLORIDE (Clinical Solutions Wholesale), ZIPRASIDONE HYDROCHLORIDE (Golden State Medical Supply), ZIPRASIDONE HYDROCHLORIDE (Proficient Rx LP), ZIPRASIDONE HYDROCHLORIDE (Proficient Rx LP), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (Aurobindo Pharma Limited), ZIPRASIDONE HYDROCHLORIDE (Avera McKennan Hospital), ZIPRASIDONE HYDROCHLORIDE (Avera McKennan Hospital), ZIPRASIDONE (Avera McKennan Hospital), ZIPRASIDONE HYDROCHLORIDE (BluePoint Laboratories), ZIPRASIDONE HYDROCHLORIDE (Bryant Ranch Prepack), ZIPRASIDONE HYDROCHLORIDE (Bryant Ranch Prepack), ZIPRASIDONE HYDROCHLORIDE (Bryant Ranch Prepack), ZIPRASIDONE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ZIPRASIDONE (Greenstone LLC), ZIPRASIDONE HYDROCHLORIDE (LUPIN LIMITED), ZIPRASIDONE HYDROCHLORIDE (Lupin Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), ZIPRASIDONE HYDROCHLORIDE (Major Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), ZIPRASIDONE HYDROCHLORIDE (Mylan Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (NCS HealthCare of KY), ZIPRASIDONE HYDROCHLORIDE (Proficient Rx LP), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (REMEDYREPACK), ZIPRASIDONE HYDROCHLORIDE (Rebel Distributors Corp), ZIPRASIDONE HYDROCHLORIDE (Sandoz), ZIPRASIDONE HYDROCHLORIDE (TYA Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (TYA Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (TYA Pharmaceuticals), ZIPRASIDONE HYDROCHLORIDE (Unit Dose Services), ZIPRASIDONE HYDROCHLORIDE (Wockhardt Limited), ZIPRASIDONE HYDROCHLORIDE (Wockhardt USA LLC.)
Formula
C21H21ClN4OS. HCl. H2O
Exact mass
466.0997
Mol weight
467.4119
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Cyp substrate
 DG01633  CYP3A substrate
Remark
ATC code: N05AE04
Chemical structure group: DG00892
Product (DG00892): D01939<US> D02100<US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Bipolar I disorder [DS:H01653]
Target
DRD2 [HSA:1813] [KO:K04145]
HTR2A [HSA:3356] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AE Indole derivatives
     N05AE04 Ziprasidone
      D01939  Ziprasidone hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Ziprasidone
    D01939  Ziprasidone hydrochloride (USAN)
 Bipolar Agents
  Bipolar Agents, Other
   Ziprasidone
    D01939  Ziprasidone hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D01939  Ziprasidone hydrochloride (USAN) <US>
   Serotonin
    HTR2A
     D01939  Ziprasidone hydrochloride (USAN) <US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D01939
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01939
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01939
BRITE hierarchy
Other DBs
CAS: 138982-67-9
PubChem: 7849001
ChEBI: 32314
ChEMBL: CHEMBL1375743
DrugBank: DB00246
LigandBox: D01939
KCF data Show

ATOM        30
            1   X   Cl   31.8552  -16.3528
            2   O0  O    32.0673  -19.1818
            3   C8y C    16.1889  -14.5797
            4   C8y C    14.9309  -15.1854
            5   N1y N    17.3536  -15.2786
            6   N5x N    16.1889  -13.1821
            7   C8y C    13.9992  -14.1139
            8   C8x C    14.5117  -16.4899
            9   C1x C    17.3535  -16.6763
            10  C1x C    18.6115  -14.5797
            11  S2x S    14.6514  -12.9026
            12  C8x C    12.6015  -14.3934
            13  C8x C    13.1605  -16.7695
            14  C1x C    18.5649  -17.3751
            15  C1x C    19.7762  -15.2786
            16  C8x C    12.1822  -15.7911
            17  N1y N    19.7762  -16.6763
            18  C1b C    21.0342  -17.3286
            19  C1b C    22.1523  -16.6297
            20  C8y C    23.3636  -17.2820
            21  C8x C    24.5749  -16.6763
            22  C8y C    23.3636  -18.7262
            23  C8y C    25.7863  -17.3286
            24  C8x C    24.5749  -19.4251
            25  X   Cl   22.1523  -19.4251
            26  C8y C    25.7863  -18.7262
            27  C1x C    27.1374  -16.9092
            28  N1x N    27.0907  -19.1921
            29  C5x C    27.9294  -18.0274
            30  O5x O    29.3270  -18.0273
BOND        32
            1     3   4 1
            2     3   5 1
            3     3   6 2
            4     4   7 2
            5     4   8 1
            6     5   9 1
            7     5  10 1
            8     6  11 1
            9     7  12 1
            10    8  13 2
            11    9  14 1
            12   10  15 1
            13   12  16 2
            14   14  17 1
            15   17  18 1
            16   18  19 1
            17   19  20 1
            18   20  21 2
            19   20  22 1
            20   21  23 1
            21   22  24 2
            22   22  25 1
            23   23  26 2
            24   23  27 1
            25   26  28 1
            26   27  29 1
            27   29  30 2
            28    7  11 1
            29   13  16 1
            30   15  17 1
            31   24  26 1
            32   28  29 1

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