| Entry |
|
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| Name |
Potassium canrenoate (JP16);
Canrenoate potassium (USAN);
Soldactone (TN)
|
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| Formula |
C22H29O4. K
|
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| Exact mass |
396.1703
|
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| Mol weight |
396.5616
|
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| Structure |
     |
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| Activity |
Aldosterone antagonist
|
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| Remark |
Therapeutic category: ATC code: |
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| Target |
mineralocorticoid receptor antagonist [HSA: 4306] [KO: K08555] |
|---|
| Pathway |
hsa04960 Aldosterone-regulated sodium reabsorption | |
|
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| Interaction |
|
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| Structure map |
| Glucocorticoid and meneralocorticoid receptor agonists/antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
213 Diuretics
2133 Antialdosterones
D01943 Potassium canrenoate (JP16); Canrenoate potassium (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03D POTASSIUM-SPARING AGENTS
C03DA Aldosterone antagonists
C03DA02 Potassium canrenoate
D01943 Potassium canrenoate (JP16); Canrenoate potassium (USAN)
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
mineralocorticoid receptor [HSA:4306] [KO:K08555]
Potassium canrenoate [ATC:C03DA02]
D01943 Canrenoate potassium (USAN)
 |
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| Other DBs |
CAS: 2181-04-6 PubChem: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 27
1 C1x C 12.3998 -16.4177
2 C5x C 12.3998 -17.7762
3 C2x C 13.5763 -18.4554
4 C2y C 14.7527 -17.7762
5 C1z C 14.7527 -16.4177
6 C1x C 13.5763 -15.7384
7 C2x C 15.9292 -18.4554
8 C2x C 17.1057 -17.7762
9 C1y C 17.1057 -16.4177
10 C1y C 15.9292 -15.7384
11 C1y C 18.2822 -15.7384
12 C1z C 18.2822 -14.3800
13 C1x C 17.1057 -13.7007
14 C1x C 15.9292 -14.3800
15 C1x C 20.6351 -15.7384
16 C1x C 20.6351 -14.3800
17 C1z C 19.4587 -13.7007
18 O1a O 19.4639 -12.3422
19 C1b C 20.6412 -13.0215
20 C1b C 21.9997 -13.0215
21 C6a C 22.6910 -11.8239
22 O6a O 24.0748 -11.8237 #-
23 O6a O 21.9819 -10.5959
24 C1a C 18.2834 -12.9821
25 C1a C 14.7338 -15.0371
26 O5x O 11.1783 -18.4813
27 Z K 26.0167 -11.9000 #+
BOND 29
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 17 18 1 #Up
22 17 19 1 #Down
23 19 20 1
24 20 21 1
25 21 22 1
26 21 23 2
27 12 24 1 #Up
28 5 25 1 #Up
29 2 26 2
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