KEGG   DRUG: D01964Help
Entry
D01964                      Drug                                   

Name
Travoprost (JAN/USAN/INN);
Travatan (TN)
Product
  Generic
Formula
C26H35F3O6
Exact mass
500.2386
Mol weight
500.5477
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of elevated intraocular pressure associated with glaucoma [prostaglandin FP-receptor agonist] [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Target
prostaglandin F receptor agonist [HSA:5737] [KO:K04262]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Prostaglandins
Antiglaucoma agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE04 Travoprost
      D01964  Travoprost (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Prostaglandin and Prostamide Analogs
   Travoprost
    D01964  Travoprost (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01964  Travoprost (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    prostaglandin F receptor
     Travoprost
      D01964  Travoprost (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
157283-68-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C1y C    19.2500  -20.4400
            2   C1y C    19.2500  -21.8400
            3   C1y C    17.8500  -20.0200
            4   C1b C    20.4400  -19.7400
            5   C1y C    17.9200  -22.2600
            6   C2b C    20.4400  -22.5400
            7   C1x C    17.0800  -21.1400
            8   C2b C    21.6300  -20.4400
            9   O1a O    17.5000  -23.6600
            10  C2b C    21.6300  -21.8400
            11  C1c C    22.8900  -22.5400
            12  C1b C    24.0800  -21.8400
            13  O1a O    22.8900  -23.9400
            14  O2a O    25.3400  -22.5400
            15  C8y C    25.3400  -23.9400
            16  C8x C    26.5300  -24.6400
            17  C8y C    26.5300  -26.0400
            18  C8x C    25.3400  -26.7400
            19  C8x C    24.0800  -26.0400
            20  C8x C    24.0800  -24.6400
            21  O1a O    17.3600  -18.6900
            22  C2b C    23.0300  -20.4400
            23  C1b C    24.2200  -19.7400
            24  C1b C    25.4100  -20.4400
            25  C1b C    26.6000  -19.7400
            26  C7a C    27.7900  -20.4400
            27  O7a O    28.9800  -19.7400
            28  C1c C    30.1700  -20.4400
            29  C1a C    31.3600  -19.7400
            30  O6a O    27.7900  -21.8400
            31  C1a C    30.1700  -21.8400
            32  C1d C    27.7453  -26.7351
            33  X   F    28.9337  -26.0423
            34  X   F    27.7511  -28.1397
            35  X   F    28.9435  -27.4205
BOND        36
            1    12  14 1
            2     5   7 1
            3    14  15 1
            4     1   2 1
            5     1   3 1
            6     1   4 1 #Down
            7     2   5 1
            8     2   6 1 #Up
            9    15  16 2
            10   16  17 1
            11   17  18 2
            12   18  19 1
            13   19  20 2
            14   20  15 1
            15    3   7 1
            16    4   8 1
            17    5   9 1 #Down
            18    6  10 2
            19   10  11 1
            20   11  12 1
            21   11  13 1 #Down
            22    3  21 1 #Down
            23    8  22 2
            24   23  24 1
            25   23  22 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   26  30 2
            32   28  31 1
            33   17  32 1
            34   32  33 1
            35   32  34 1
            36   32  35 1

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