KEGG   DRUG: D01965Help
Entry
D01965                      Drug                                   

Name
Silodosin (JAN/INN);
KMD 3213;
Rapaflo (TN);
Urief (TN)
Product
Formula
C25H32F3N3O4
Exact mass
495.2345
Mol weight
495.5345
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Therapeutic category: 
ATC code: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], UGT [KO:K00699]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01965  Silodosin (JAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA04 Silodosin
      D01965  Silodosin (JAN/INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Silodosin
    D01965  Silodosin (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Silodosin [ATC:G04CA04]
      D01965  Silodosin (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
160970-54-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        35
            1   C8y C    25.3627  -16.7293
            2   C8x C    25.3627  -18.1293
            3   C8y C    26.5750  -18.8293
            4   C8y C    27.7875  -18.1293
            5   C8y C    27.7875  -16.7293
            6   C8x C    26.5750  -16.0294
            7   N1y N    29.1189  -18.5619
            8   C1x C    29.9418  -17.4293
            9   C1x C    29.1189  -16.2967
            10  C1b C    29.5453  -19.8751
            11  C1b C    30.9269  -20.1692
            12  C1b C    31.3587  -21.4994
            13  O1a O    32.7377  -21.7931
            14  C5a C    26.5750  -20.2312
            15  N1a N    25.3646  -20.9301
            16  O5a O    27.7896  -20.9325
            17  C1b C    24.1519  -16.0310
            18  C1c C    22.9393  -16.7310
            19  N1b N    21.7269  -16.0310
            20  C1b C    20.5143  -16.7310
            21  C1b C    19.3018  -16.0310
            22  O2a O    18.0893  -16.7310
            23  C8y C    16.8768  -16.0310
            24  C1a C    22.9375  -18.1311
            25  C8y C    16.8768  -14.6309
            26  C8x C    15.6643  -13.9309
            27  C8x C    14.4518  -14.6309
            28  C8x C    14.4518  -16.0310
            29  C8x C    15.6643  -16.7310
            30  O2a O    18.0846  -13.9336
            31  C1b C    19.2952  -14.6325
            32  C1d C    20.5100  -13.9312
            33  X   F    20.5106  -12.5306
            34  X   F    21.7226  -14.6316
            35  X   F    21.7240  -13.2307
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    7  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15    3  14 1
            16   14  15 1
            17   14  16 2
            18    1  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   18  24 1 #Up
            26   23  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   23  29 1
            32   25  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   32  34 1
            37   32  35 1

» Japanese version   » Back

DBGET integrated database retrieval system