KEGG   DRUG: Tenofovir disoproxil fumarateHelp
Entry
D01982                      Drug                                   

Name
Tenofovir disoproxil fumarate (JAN/USAN);
Viread (TN)
Product
Formula
C19H30N5O10P. C4H4O4
Exact mass
635.184
Mol weight
635.5149
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor
 DG01656  HIV reverse transcriptase inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Comment
Nucleoside reverse transcriptase inhibitor (NRTI)
Active form of prodrug: Tenofovir [DR:D06074]
Target
RNA-directed DNA polymerase
Interaction
Drug interaction
Structure map
Antiviral agents
Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF07 Tenofovir disoproxil
      D01982  Tenofovir disoproxil fumarate (JAN/USAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Tenofovir
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Tenofovir
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D01982  Tenofovir disoproxil fumarate (JAN/USAN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Reverse transcriptase inhibitor (RTI)
    Nucleoside and nucleotide reverse transcriptase inhibitor (NRTIs)
     Tenofovir
      D01982  Tenofovir disoproxil fumarate (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2B6
   Tenofovir
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
 Transporter substrates
  ABCC4
   Tenofovir
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
  OAT1
   Tenofovir
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
Antivirals [br08351.html]
 D01982
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01982
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01982
BRITE hierarchy
Other DBs
CAS: 
202138-50-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        43
            1   C6a C    30.8992  -18.5945
            2   C2b C    32.1576  -19.2936
            3   C2b C    33.3460  -18.5945
            4   C6a C    34.5345  -19.2936
            5   O6a O    35.7928  -18.5945
            6   O6a O    29.7108  -19.2936
            7   O6a O    30.8992  -17.1963
            8   O6a O    34.5345  -20.6917
            9   C8y C    26.5368  -16.8840
            10  C8y C    26.5368  -15.4243
            11  N4y N    25.2162  -17.3012
            12  N5x N    27.7880  -17.5096
            13  N5x N    25.2162  -15.0073
            14  C8y C    27.7880  -14.7987
            15  C8x C    24.3820  -16.1889
            16  C8x C    28.9697  -16.8840
            17  N5x N    28.9697  -15.4243
            18  N1a N    27.7880  -13.4085
            19  C1b C    25.2162  -18.6945
            20  C1c C    24.0155  -19.3876
            21  O2a O    22.8023  -18.6870
            22  C1b C    21.5805  -19.3928
            23  P1b P    20.3622  -18.6904
            24  O2b O    19.1554  -17.9937
            25  O2b O    19.6691  -19.8908
            26  O3b O    21.0616  -17.4784
            27  C1b C    19.1554  -16.5955
            28  C1b C    19.6691  -21.2890
            29  O7a O    17.9438  -15.8681
            30  C7a C    16.7329  -16.5671
            31  O7a O    15.5220  -15.8681
            32  C1c C    14.3112  -16.5671
            33  C1a C    13.1003  -15.8681
            34  O7a O    18.4331  -22.0200
            35  C7a C    17.2222  -21.3209
            36  O7a O    16.0114  -22.0200
            37  C1c C    14.8006  -21.3209
            38  C1a C    13.5897  -22.0200
            39  O6a O    16.7329  -17.9651
            40  C1a C    14.3112  -17.9652
            41  O6a O    17.2222  -19.9230
            42  C1a C    14.8006  -19.9229
            43  C1a C    24.0154  -20.7900
BOND        43
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   6 1
            6     1   7 2
            7     4   8 2
            8    10  13 1
            9    10  14 1
            10   11  15 1
            11   12  16 2
            12   14  17 2
            13   13  15 2
            14   16  17 1
            15    9  10 2
            16    9  11 1
            17    9  12 1
            18   14  18 1
            19   11  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   23  25 1
            26   23  26 2
            27   24  27 1
            28   25  28 1
            29   27  29 1
            30   29  30 1
            31   30  31 1
            32   31  32 1
            33   32  33 1
            34   28  34 1
            35   34  35 1
            36   35  36 1
            37   36  37 1
            38   37  38 1
            39   30  39 2
            40   32  40 1
            41   35  41 2
            42   37  42 1
            43   20  43 1 #Up

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