KEGG   DRUG: Tosufloxacin tosylate hydrateHelp
Entry
D01996                      Drug                                   

Name
Tosufloxacin tosylate hydrate (JP17);
Tosufloxacin tosilate;
TFLX;
Ozex (TN);
Tosuxacin (TN)
Formula
C19H15F3N4O3. C7H8O3S. H2O
Exact mass
594.1396
Mol weight
594.5595
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Therapeutic category: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621] [KO:K02622]
Interaction
Drug interaction
Structure map
Quinolones
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01996  Tosufloxacin tosylate hydrate (JP17)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D01996  Tosufloxacin tosylate hydrate (JP17)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Tosufloxacin
      D01996  Tosufloxacin tosylate hydrate (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01996  Tosufloxacin tosilate hydrate
  D01996  Tosufloxacin tosilate tablets
Antibacterials [br08350.html]
 D01996
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        41
            1   C8y C    18.4652  -14.7295
            2   N4y N    19.6754  -15.4278
            3   C8y C    18.4652  -13.3329
            4   N5x N    17.2548  -15.4278
            5   C8y C    19.6755  -16.8243
            6   C8x C    20.8859  -14.7295
            7   C8y C    19.6290  -12.6346
            8   C8x C    17.2548  -12.6346
            9   C8y C    16.0444  -14.7295
            10  C8y C    20.8860  -17.5227
            11  C8x C    18.4652  -17.5227
            12  C8y C    20.8859  -13.3329
            13  O5x O    19.6290  -11.2380
            14  C8y C    16.0444  -13.3329
            15  N1y N    14.8340  -15.4742
            16  C8x C    20.8860  -18.9657
            17  X   F    22.0963  -16.8243
            18  C8x C    18.4652  -18.9193
            19  C6a C    22.0497  -12.6346
            20  X   F    14.8340  -12.6346
            21  C8y C    19.6755  -19.6174
            22  O6a O    23.2601  -13.3329
            23  O6a O    22.0497  -11.2380
            24  X   F    19.6755  -21.0605
            25  C1x C    13.5475  -14.9442
            26  C1x C    12.6459  -16.0041
            27  C1y C    13.3752  -17.1890
            28  C1x C    14.8208  -16.8616
            29  N1a N    12.8271  -18.4910
            30  C8y C    26.9981  -15.7899
            31  C8x C    25.7805  -16.4924
            32  C8x C    28.2156  -16.4924
            33  S4a S    26.9980  -14.4316
            34  C8x C    25.7805  -17.8973
            35  C8x C    28.2156  -17.8973
            36  O1d O    25.5931  -14.4316
            37  O1d O    28.4029  -14.4316
            38  O1d O    26.9980  -13.0736
            39  C8y C    26.9981  -18.6465
            40  C1a C    26.9981  -20.0046
            41  O0  O    31.5933  -16.1000
BOND        43
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 2
            13    8  14 2
            14    9  15 1
            15   10  16 1
            16   10  17 1
            17   11  18 2
            18   12  19 1
            19   14  20 1
            20   16  21 2
            21   19  22 1
            22   19  23 2
            23   21  24 1
            24    7  12 1
            25    9  14 1
            26   18  21 1
            27   15  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   15  28 1
            32   27  29 1
            33   30  31 1
            34   30  32 2
            35   30  33 1
            36   31  34 2
            37   32  35 1
            38   33  36 2
            39   33  37 2
            40   33  38 1
            41   34  39 1
            42   39  40 1
            43   35  39 2

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