| Entry |
|
|---|
| Name |
Isoniazid sodium methanesulfonate hydrate (JAN);
Isoniazid sodium methanesulfonate monohydrate;
Isoniazid sodium methanesulfonate;
IHMS;
Neoiscotin (TN)
|
|---|
| Formula |
C7H8N3O4S. Na. H2O
|
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| Exact mass |
271.0239
|
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| Mol weight |
271.2262
|
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| Structure |
     |
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| Activity |
|
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| Remark |
Therapeutic category: ATC code: |
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| Target |
enoyl-[acyl-carrier-protein] reductase (NADH) [KO: K11611]; monoamine oxidase (MAO) inhibitor [HSA: 4128 4129] [KO: K00274] |
|---|
| Interaction |
CYP inhibition: CYP2C9 [HSA: 1559], CYP3A [KO: K07424]
 |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
622 Tuberculosis preparations
6222 Isoniazids
D02002 Isoniazid sodium methanesulfonate hydrate (JAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J04 ANTIMYCOBACTERIALS
J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
J04AC Hydrazides
J04AC01 Isoniazid
D02002 Isoniazid sodium methanesulfonate hydrate (JAN)
USP drug classification [BR:br08302]
Antimycobacterials
Antituberculars
Isoniazid
D02002 Isoniazid sodium methanesulfonate hydrate (JAN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases
monoamine oxidase (MAO) [HSA:4128 4129] [KO:K00274]
Isoniazid [ATC:J04AC01]
D02002 Isoniazid sodium methanesulfonate hydrate (JAN)
Antiinfectives [BR:br08307]
Antibacterials
Cell wall biosynthesis inhibitor
Others
enoyl-[acyl-carrier-protein] reductase (NADH) inhibitor [KO:K11611]
Isoniazid; Antituberculous [ATC:J04AC01]
D02002 Isoniazid sodium methanesulfonate hydrate (JAN)
 |
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| Other DBs |
PubChem: DrugBank: LigandBox: |
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| KCF data |
ATOM 17
1 N5x N 7.2800 -10.5700
2 C8x C 7.2800 -11.9700
3 C8x C 8.4924 -12.6700
4 C8y C 9.7049 -11.9700
5 C8x C 9.7049 -10.5700
6 C8x C 8.4924 -9.8700
7 C5a C 10.9424 -12.6700
8 N1b N 12.1549 -11.9700
9 N1b N 13.3673 -12.6700
10 C1b C 14.5797 -11.9700
11 S4a S 15.7922 -12.6700
12 O1d O 17.0046 -11.9700 #-
13 O5a O 10.9486 -14.0697
14 O1d O 14.8022 -13.6599
15 O1d O 16.7821 -13.6599
16 Z Na 18.8300 -11.9700 #+
17 O0 O 20.1600 -13.8600
BOND 15
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 7 13 2
14 11 14 2
15 11 15 2
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