KEGG   DRUG: D02002Help
Entry
D02002                      Drug                                   

Name
Isoniazid sodium methanesulfonate hydrate (JAN);
Isoniazid sodium methanesulfonate monohydrate;
Isoniazid sodium methanesulfonate;
IHMS;
Neoiscotin (TN)
Formula
C7H8N3O4S. Na. H2O
Exact mass
271.0239
Mol weight
271.2262
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antituberculous [DS:H00342]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K11611];
monoamine oxidase (MAO) inhibitor [HSA:4128 4129] [KO:K00274]
Interaction
CYP induction: CYP2E1 [HSA:1571]
CYP inhibition: CYP2C9 [HSA:1559], CYP3A [HSA:1576 1577 1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AC Hydrazides
     J04AC01 Isoniazid
      D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
USP drug classification [BR:br08302]
 Antimycobacterials
  Antituberculars
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   622  Tuberculosis preparations
    6222  Isoniazids
     D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   monoamine oxidase (MAO)
    Isoniazid
     D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Others
    enoyl-[acyl-carrier-protein] reductase (NADH) inhibitor
     Isoniazid
      D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C9
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
  CYP3A
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
 Inducers
  CYP2E1
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        17
            1   N5x N     7.2800  -10.5700
            2   C8x C     7.2800  -11.9700
            3   C8x C     8.4924  -12.6700
            4   C8y C     9.7049  -11.9700
            5   C8x C     9.7049  -10.5700
            6   C8x C     8.4924   -9.8700
            7   C5a C    10.9424  -12.6700
            8   N1b N    12.1549  -11.9700
            9   N1b N    13.3673  -12.6700
            10  C1b C    14.5797  -11.9700
            11  S4a S    15.7922  -12.6700
            12  O1d O    17.0046  -11.9700 #-
            13  O5a O    10.9486  -14.0697
            14  O1d O    14.8022  -13.6599
            15  O1d O    16.7821  -13.6599
            16  Z   Na   18.8300  -11.9700 #+
            17  O0  O    20.1600  -13.8600
BOND        15
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    7  13 2
            14   11  14 2
            15   11  15 2

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