KEGG   DRUG: D02002Help
Entry
D02002                      Drug                                   

Name
Isoniazid sodium methanesulfonate hydrate (JAN);
Isoniazid sodium methanesulfonate monohydrate;
Isoniazid sodium methanesulfonate;
IHMS;
Neoiscotin (TN)
Formula
C7H8N3O4S. Na. H2O
Exact mass
271.0239
Mol weight
271.2262
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antituberculous [DS:H00342]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K11611];
monoamine oxidase (MAO) inhibitor [HSA:4128 4129] [KO:K00274]
Interaction
CYP induction: CYP2E1 [HSA:1571]
CYP inhibition: CYP2C9 [HSA:1559], CYP3A [HSA:1576 1577 1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AC Hydrazides
     J04AC01 Isoniazid
      D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
USP drug classification [BR:br08302]
 Antimycobacterials
  Antituberculars
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   622  Tuberculosis preparations
    6222  Isoniazids
     D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   monoamine oxidase (MAO)
    Isoniazid
     D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C9
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
  CYP3A
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
 Inducers
  CYP2E1
   Isoniazid
    D02002  Isoniazid sodium methanesulfonate hydrate (JAN)
Antiinfectives [br08307.html]
 Antibacterials
  DG00642
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        17
            1   N5x N     7.2800  -10.5700
            2   C8x C     7.2800  -11.9700
            3   C8x C     8.4924  -12.6700
            4   C8y C     9.7049  -11.9700
            5   C8x C     9.7049  -10.5700
            6   C8x C     8.4924   -9.8700
            7   C5a C    10.9424  -12.6700
            8   N1b N    12.1549  -11.9700
            9   N1b N    13.3673  -12.6700
            10  C1b C    14.5797  -11.9700
            11  S4a S    15.7922  -12.6700
            12  O1d O    17.0046  -11.9700 #-
            13  O5a O    10.9486  -14.0697
            14  O1d O    14.8022  -13.6599
            15  O1d O    16.7821  -13.6599
            16  Z   Na   18.8300  -11.9700 #+
            17  O0  O    20.1600  -13.8600
BOND        15
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    7  13 2
            14   11  14 2
            15   11  15 2

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