KEGG   DRUG: D02004Help
Entry
D02004                      Drug                                   

Name
Apomorphine hydrochloride hydrate (JAN);
Apomorphine hydrochloride (USP);
Apokyn (TN);
Ixense (TN);
Uprima (TN)
Product
Formula
(C17H17NO2)2. 2HCl. H2O
Exact mass
624.2158
Mol weight
625.5819
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Emetic [DS:H00057]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
dopamine D1-receptor agonist [HSA:1812] [KO:K04144];
dopamine D2-receptor agonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC07 Apomorphine
      D02004  Apomorphine hydrochloride hydrate (JAN); Apomorphine hydrochloride (USP)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Agonists
   Apomorphine
    D02004  Apomorphine hydrochloride hydrate (JAN); Apomorphine hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D02004  Apomorphine hydrochloride hydrate (JAN); Apomorphine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D1-receptor
     Apomorphine
      D02004  Apomorphine hydrochloride hydrate (JAN); Apomorphine hydrochloride (USP)
    dopamine D2-receptor
     Apomorphine
      D02004  Apomorphine hydrochloride hydrate (JAN); Apomorphine hydrochloride (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tyrosine
   Isoquinoline alkaloids
    D02004  Apomorphine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
41372-20-7
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        43
            1   X   Cl   33.3062  -14.8324
            2   O0  O    33.6561  -17.2812
            3   C8x C    19.8800  -17.2200
            4   C8x C    19.8800  -18.6200
            5   C8x C    21.0700  -19.3200
            6   C8y C    22.3300  -18.6200
            7   C8y C    22.3300  -17.2200
            8   C8y C    21.0700  -16.5200
            9   C1x C    23.5200  -19.3200
            10  C1x C    24.7100  -18.6200
            11  N1y N    24.7100  -17.2200
            12  C1y C    23.5200  -16.5200
            13  C1x C    23.5200  -15.1200
            14  C8y C    22.3300  -14.4200
            15  C8y C    21.0700  -15.1200
            16  C8x C    22.3300  -13.0200
            17  C8x C    21.0700  -12.3200
            18  C8y C    19.8800  -13.0200
            19  C8y C    19.8800  -14.4200
            20  C1a C    25.9700  -16.5200
            21  O1a O    18.6900  -12.3200
            22  O1a O    18.6900  -15.1200
            23  X   Cl   33.3062  -14.8324
            24  C8x C    19.8800  -17.2200
            25  C8x C    19.8800  -18.6200
            26  C8x C    21.0700  -19.3200
            27  C8y C    22.3300  -18.6200
            28  C8y C    22.3300  -17.2200
            29  C8y C    21.0700  -16.5200
            30  C8y C    21.0700  -15.1200
            31  C8y C    22.3300  -14.4200
            32  C1x C    23.5200  -15.1200
            33  C1y C    23.5200  -16.5200
            34  N1y N    24.7100  -17.2200
            35  C1x C    24.7100  -18.6200
            36  C1x C    23.5200  -19.3200
            37  C1a C    25.9700  -16.5200
            38  C8x C    22.3300  -13.0200
            39  C8x C    21.0700  -12.3200
            40  C8y C    19.8800  -13.0200
            41  C8y C    19.8800  -14.4200
            42  O1a O    18.6900  -15.1200
            43  O1a O    18.6900  -12.3200
BOND        46
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     6   9 1
            8     9  10 1
            9    10  11 1
            10   11  12 1
            11    7  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 2
            15    8  15 1
            16   14  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   15  19 1
            21   11  20 1
            22   18  21 1
            23   19  22 1
            24   24  25 2
            25   25  26 1
            26   26  27 2
            27   27  28 1
            28   28  29 2
            29   24  29 1
            30   27  36 1
            31   36  35 1
            32   35  34 1
            33   34  33 1
            34   28  33 1
            35   33  32 1
            36   32  31 1
            37   31  30 2
            38   29  30 1
            39   31  38 1
            40   38  39 2
            41   39  40 1
            42   40  41 2
            43   30  41 1
            44   34  37 1
            45   40  43 1
            46   41  42 1
BRACKET     1    31.5700  -15.6100   31.5700  -14.0700
            1    34.1600  -14.0700   34.1600  -15.6100
            1  2
 ORIGINAL  1    1
 REPEAT    1   24
            2    16.7300  -20.2300   16.7300  -11.4800
            2    28.2100  -11.4800   28.2100  -20.2300
            2  2
 ORIGINAL  2    3   4   5   6   7   8  15  14  13  12  11  10   9  21  20  16
            2   17  18  19  23  22
 REPEAT    2   25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
            2   41  42  43  44  45

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