KEGG   DRUG: D02007Help
Entry
D02007                      Drug                                   

Name
Protirelin tartrate hydrate (JP16);
Hirtonin (TN)
Formula
C16H22N6O4. C4H6O6. H2O
Exact mass
530.1973
Mol weight
530.4858
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Prothyrotropin
Remark
Therapeutic category: 
ATC code: 
Comment
tripeptide
Target
Thyrotropin-releasing hormone receptor agonist [HSA:7201] [KO:K04282]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02007  Protirelin tartrate hydrate (JP16)
 7  Agents not mainly for therapeutic purpose
  72  Intracorporeal diagnostic agents
   722  Various function testing reagents
    7223  Diagnostic reagents for endocrine function
     D02007  Protirelin tartrate hydrate (JP16)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V04 DIAGNOSTIC AGENTS
   V04C OTHER DIAGNOSTIC AGENTS
    V04CJ Tests for thyreoidea function
     V04CJ02 Protirelin
      D02007  Protirelin tartrate hydrate (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Thyrotropin-releasing hormone
    Thyrotropin-releasing hormone (TRH) receptor [HSA:7201] [KO:K04282]
     Protirelin [ATC:V04CJ02]
      D02007  Protirelin tartrate hydrate (JP16)
BRITE hierarchy
Other DBs
CAS: 
53935-32-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        37
            1   C1x C    16.1545  -21.0629
            2   C1y C    16.5734  -19.7134
            3   N1x N    15.4564  -18.8757
            4   C5x C    14.2929  -19.7134
            5   C1x C    14.7583  -21.0629
            6   C8y C    21.4135  -16.9676
            7   C8x C    22.8097  -16.9676
            8   N5x N    23.2285  -15.6177
            9   C8x C    22.1116  -14.8266
            10  N4x N    20.9946  -15.6177
            11  C1x C    24.4385  -17.7122
            12  C1x C    24.9039  -19.0618
            13  C1y C    23.7404  -19.8996
            14  N1y N    22.6235  -19.0618
            15  C1x C    23.0424  -17.7122
            16  C5a C    21.4135  -19.7599
            17  C1c C    20.2035  -19.0618
            18  N1b N    18.9933  -19.7599
            19  C5a C    17.7834  -19.0618
            20  O5a O    17.7834  -17.6657
            21  C1b C    20.2035  -17.6657
            22  C5a C    23.7404  -21.2956
            23  O5a O    22.5304  -21.9937
            24  N1a N    24.9505  -21.9937
            25  O5a O    21.4135  -21.1560
            26  O5x O    12.9897  -19.2945
            27  O6a O    27.9304  -17.6636
            28  C6a C    29.1429  -16.9636
            29  C1c C    30.3553  -17.6636
            30  C1c C    31.5677  -16.9636
            31  C6a C    32.7802  -17.6636
            32  O6a O    33.9926  -16.9636
            33  O6a O    29.1429  -15.5636
            34  O1a O    31.5677  -15.5636
            35  O1a O    30.3553  -19.0636
            36  O6a O    32.7802  -19.0636
            37  O0  O    31.5001  -21.8634
BOND        37
            1    11  12 1
            2    12  13 1
            3    13  14 1
            4    14  15 1
            5    15  11 1
            6     4   5 1
            7    14  16 1
            8     6   7 2
            9    16  17 1
            10    7   8 1
            11   17  18 1
            12    8   9 2
            13   18  19 1
            14    9  10 1
            15   19  20 2
            16   10   6 1
            17   17  21 1 #Up
            18   21   6 1
            19    5   1 1
            20   13  22 1 #Up
            21   22  23 2
            22    1   2 1
            23   22  24 1
            24    2   3 1
            25   16  25 2
            26    2  19 1 #Down
            27    3   4 1
            28    4  26 2
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   31  32 1
            34   28  33 2
            35   30  34 1 #Up
            36   29  35 1 #Up
            37   31  36 2

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