KEGG   DRUG: D02009Help
Entry
D02009                      Drug                                   

Name
Erythromycin lactobionate (JP16/USP);
EML;
Erythrocin (TN)
Product
  Generic
Formula
C37H67NO13. C12H22O12
Exact mass
1091.5724
Mol weight
1092.2227
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02009  Erythromycin lactobionate (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D02009  Erythromycin lactobionate (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Erythromycin
      D02009  Erythromycin lactobionate (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
  CYP3A5
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
  CYP3A7
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
 Inhbitors
  CYP2C19
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
  CYP3A4
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
  CYP3A7
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
  CYP3A
   Erythromycin
    D02009  Erythromycin lactobionate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02009  Erythromycin lactobionate
BRITE hierarchy
Other DBs
CAS: 
3847-29-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        75
            1   C1y C    35.9989  -17.5847
            2   C1y C    35.9989  -18.9757
            3   C1y C    37.2044  -19.6713
            4   C1y C    38.3636  -18.9757
            5   O2x O    38.3636  -17.5847
            6   C1y C    37.2044  -16.9355
            7   O2a O    37.2044  -15.5446
            8   C1c C    38.3636  -14.8490
            9   C1c C    39.5692  -15.5446
            10  C1b C    40.7747  -14.8490
            11  O1a O    41.9803  -15.5446
            12  C1c C    38.3636  -12.9015
            13  C1c C    39.5692  -12.2060
            14  O1a O    37.2044  -12.2060
            15  C6a C    40.7747  -12.9015
            16  O1a O    39.5692  -10.8614
            17  O6a O    41.9803  -12.2060
            18  O6a O    40.7747  -14.2925
            19  O1a O    39.5692  -16.9355
            20  C1b C    39.5692  -19.6713
            21  O1a O    40.7747  -18.9757
            22  O1a O    37.2044  -21.0623
            23  O1a O    34.7933  -19.6713
            24  O1a O    34.7933  -16.9355
            25  C1y C    25.9003  -13.1765
            26  C1z C    25.9003  -11.8133
            27  C1y C    24.7162  -13.8524
            28  O2a O    27.8815  -13.8928
            29  C1x C    24.7162  -11.1317
            30  O1a O    26.9284  -10.8256
            31  C1a C    27.1826  -12.2464
            32  C1y C    24.7162  -15.2156
            33  C1a C    23.7455  -12.8307
            34  C1y C    29.4593  -13.1780
            35  C1y C    24.7162   -9.7627
            36  O2a O    25.4556  -16.5730
            37  C1y C    23.5436  -15.8973
            38  C1y C    30.6274  -13.8692
            39  O2x O    29.4713  -11.8153
            40  C5x C    23.5436   -9.0868
            41  C1a C    25.9003   -9.0868
            42  C1y C    26.9716  -16.9909
            43  C7x C    22.3595  -15.2156
            44  C1a C    23.5436  -17.2603
            45  C1y C    31.8829  -13.2076
            46  O1a O    30.6183  -15.2369
            47  C1y C    30.6617  -11.1510
            48  C1y C    22.3595   -9.7627
            49  O5x O    23.5436   -7.7236
            50  C1x C    26.9716  -18.3484
            51  O2x O    28.1558  -16.3094
            52  O7x O    22.3595  -13.8524
            53  O6a O    21.3024  -16.1629
            54  C1x C    31.8273  -11.8500
            55  N1c N    32.9858  -13.8960
            56  C1a C    30.6814   -9.7905
            57  C1y C    22.3595  -11.1317
            58  C1a C    21.1812   -9.0868
            59  C1z C    28.1558  -19.0358
            60  C1y C    29.3282  -16.9909
            61  C1y C    21.1812  -13.1765
            62  C1z C    21.1812  -11.8133
            63  O1a O    23.5436  -11.8133
            64  C1y C    29.3282  -18.3484
            65  O2a O    28.1558  -20.3586
            66  C1a C    29.5998  -20.0178
            67  C1a C    30.5124  -16.3152
            68  C1b C    20.0027  -13.8524
            69  C1a C    19.9335  -12.3792
            70  O1a O    19.9335  -11.1260
            71  O1a O    30.5124  -19.0358
            72  C1a C    29.2532  -21.3175
            73  C1a C    20.0377  -14.9729
            74  C1a C    34.2321  -13.1885
            75  C1a C    32.9764  -15.2577
BOND        77
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Down
            8     8   7 1 #Up
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    8  12 1
            13   12  13 1
            14   12  14 1 #Down
            15   13  15 1
            16   13  16 1 #Up
            17   15  17 1
            18   15  18 2
            19    9  19 1 #Up
            20    4  20 1 #Down
            21   20  21 1
            22    3  22 1 #Down
            23    2  23 1 #Down
            24    1  24 1 #Up
            25   25  26 1
            26   25  27 1
            27   25  28 1 #Down
            28   26  29 1
            29   26  30 1 #Up
            30   26  31 1 #Down
            31   27  32 1
            32   27  33 1 #Down
            33   34  28 1 #Down
            34   29  35 1
            35   32  36 1 #Down
            36   32  37 1
            37   34  38 1
            38   34  39 1
            39   35  40 1
            40   35  41 1 #Down
            41   42  36 1 #Down
            42   37  43 1
            43   37  44 1 #Up
            44   38  45 1
            45   38  46 1 #Up
            46   39  47 1
            47   40  48 1
            48   40  49 2
            49   42  50 1
            50   42  51 1
            51   43  52 1
            52   43  53 2
            53   45  54 1
            54   45  55 1 #Down
            55   47  56 1 #Down
            56   48  57 1
            57   48  58 1 #Up
            58   50  59 1
            59   51  60 1
            60   52  61 1
            61   57  62 1
            62   57  63 1 #Up
            63   59  64 1
            64   59  65 1 #Down
            65   59  66 1
            66   60  67 1 #Up
            67   61  68 1 #Down
            68   62  69 1 #Down
            69   62  70 1 #Up
            70   64  71 1 #Down
            71   65  72 1
            72   68  73 1
            73   47  54 1
            74   60  64 1
            75   61  62 1
            76   55  74 1
            77   55  75 1

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