| Entry |
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| Name |
Erythromycin lactobionate (JP18/USP);
Erythrocin (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C37H67NO13. C12H22O12
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| Exact mass |
1091.5724
|
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| Mol weight |
1092.2227
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| Structure |
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| Simcomp |
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| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
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| Remark |
| Therapeutic category: | 6141 |
| Product (DG00436): | D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US> |
| Product (mixture): | D04099<JP> |
|
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| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
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| Disease |
|
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| Target |
50S ribosomal subunit |
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| Pathway |
|
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| Metabolism |
|
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| Interaction |
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: ABCB1 [HSA: 5243]
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF02 Erythromycin
D02009 Erythromycin lactobionate (JP18/USP) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA01 Erythromycin
D02009 Erythromycin lactobionate (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA17 Erythromycin
D02009 Erythromycin lactobionate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Macrolides
Erythromycin
D02009 Erythromycin lactobionate (JP18/USP)
Dermatological Agents
Topical Anti-infectives
Antibacterials, dermatological
Erythromycin
D02009 Erythromycin lactobionate (JP18/USP)
Ophthalmic Agents
Ophthalmic Anti-Infectives
Antibacterials, Ophthalmic
Erythromycin
D02009 Erythromycin lactobionate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6141 Erythromycins
D02009 Erythromycin lactobionate (JP18/USP)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
D02009 Erythromycin lactobionate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
D02009 Erythromycin lactobionate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
D02009 Erythromycin lactobionate
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
D02009 Erythromycin lactobionate
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D02009 Erythromycin lactobionate
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D02009 Erythromycin lactobionate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02009 Erythromycin lactobionate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02009
Drug transporters
D02009
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00436 Erythromycin
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| Other DBs |
|
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| KCF data |
ATOM 75
1 C1y C 35.9989 -17.5847
2 C1y C 35.9989 -18.9757
3 C1y C 37.2044 -19.6713
4 C1y C 38.3636 -18.9757
5 O2x O 38.3636 -17.5847
6 C1y C 37.2044 -16.9355
7 O2a O 37.2044 -15.5446
8 C1c C 38.3636 -14.8490
9 C1c C 39.5692 -15.5446
10 C1b C 40.7747 -14.8490
11 O1a O 41.9803 -15.5446
12 C1c C 38.3636 -12.9015
13 C1c C 39.5692 -12.2060
14 O1a O 37.2044 -12.2060
15 C6a C 40.7747 -12.9015
16 O1a O 39.5692 -10.8614
17 O6a O 41.9803 -12.2060
18 O6a O 40.7747 -14.2925
19 O1a O 39.5692 -16.9355
20 C1b C 39.5692 -19.6713
21 O1a O 40.7747 -18.9757
22 O1a O 37.2044 -21.0623
23 O1a O 34.7933 -19.6713
24 O1a O 34.7933 -16.9355
25 C1y C 25.9003 -13.1765
26 C1z C 25.9003 -11.8133
27 C1y C 24.7162 -13.8524
28 O2a O 27.8815 -13.8928
29 C1x C 24.7162 -11.1317
30 O1a O 26.9284 -10.8256
31 C1a C 27.1826 -12.2464
32 C1y C 24.7162 -15.2156
33 C1a C 23.7455 -12.8307
34 C1y C 29.4593 -13.1780
35 C1y C 24.7162 -9.7627
36 O2a O 25.4556 -16.5730
37 C1y C 23.5436 -15.8973
38 C1y C 30.6274 -13.8692
39 O2x O 29.4713 -11.8153
40 C5x C 23.5436 -9.0868
41 C1a C 25.9003 -9.0868
42 C1y C 26.9716 -16.9909
43 C7x C 22.3595 -15.2156
44 C1a C 23.5436 -17.2603
45 C1y C 31.8829 -13.2076
46 O1a O 30.6183 -15.2369
47 C1y C 30.6617 -11.1510
48 C1y C 22.3595 -9.7627
49 O5x O 23.5436 -7.7236
50 C1x C 26.9716 -18.3484
51 O2x O 28.1558 -16.3094
52 O7x O 22.3595 -13.8524
53 O6a O 21.3024 -16.1629
54 C1x C 31.8273 -11.8500
55 N1c N 32.9858 -13.8960
56 C1a C 30.6814 -9.7905
57 C1y C 22.3595 -11.1317
58 C1a C 21.1812 -9.0868
59 C1z C 28.1558 -19.0358
60 C1y C 29.3282 -16.9909
61 C1y C 21.1812 -13.1765
62 C1z C 21.1812 -11.8133
63 O1a O 23.5436 -11.8133
64 C1y C 29.3282 -18.3484
65 O2a O 28.1558 -20.3586
66 C1a C 29.5998 -20.0178
67 C1a C 30.5124 -16.3152
68 C1b C 20.0027 -13.8524
69 C1a C 19.9335 -12.3792
70 O1a O 19.9335 -11.1260
71 O1a O 30.5124 -19.0358
72 C1a C 29.2532 -21.3175
73 C1a C 20.0377 -14.9729
74 C1a C 34.2321 -13.1885
75 C1a C 32.9764 -15.2577
BOND 77
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 6 7 1 #Down
8 8 7 1 #Up
9 8 9 1
10 9 10 1
11 10 11 1
12 8 12 1
13 12 13 1
14 12 14 1 #Down
15 13 15 1
16 13 16 1 #Up
17 15 17 1
18 15 18 2
19 9 19 1 #Up
20 4 20 1 #Down
21 20 21 1
22 3 22 1 #Down
23 2 23 1 #Down
24 1 24 1 #Up
25 25 26 1
26 25 27 1
27 25 28 1 #Down
28 26 29 1
29 26 30 1 #Up
30 26 31 1 #Down
31 27 32 1
32 27 33 1 #Down
33 34 28 1 #Down
34 29 35 1
35 32 36 1 #Down
36 32 37 1
37 34 38 1
38 34 39 1
39 35 40 1
40 35 41 1 #Down
41 42 36 1 #Down
42 37 43 1
43 37 44 1 #Up
44 38 45 1
45 38 46 1 #Up
46 39 47 1
47 40 48 1
48 40 49 2
49 42 50 1
50 42 51 1
51 43 52 1
52 43 53 2
53 45 54 1
54 45 55 1 #Down
55 47 56 1 #Down
56 48 57 1
57 48 58 1 #Up
58 50 59 1
59 51 60 1
60 52 61 1
61 57 62 1
62 57 63 1 #Up
63 59 64 1
64 59 65 1 #Down
65 59 66 1
66 60 67 1 #Up
67 61 68 1 #Down
68 62 69 1 #Down
69 62 70 1 #Up
70 64 71 1 #Down
71 65 72 1
72 68 73 1
73 47 54 1
74 60 64 1
75 61 62 1
76 55 74 1
77 55 75 1
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