KEGG   DRUG: D02014Help
Entry
D02014                      Drug                                   

Name
Angiotensin II (human type) (JAN);
Delivert (TN)
Formula
C50H71N13O12
Exact mass
1045.5345
Mol weight
1046.1786
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
Asp Arg Val Tyr Ile His Pro Phe
  Type
Peptide
Activity
Vasoconstrictor
Comment
Angiotensin analogue
Target
angiotensin II receptor type 1 agonist [HSA:185] [KO:K04166];
angiotensin II receptor type 2 agonist [HSA:186] [KO:K04167]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor [HSA:185] [KO:K04166]
     Angiotensin II (human type)
      D02014  Angiotensin II (human type) (JAN)
    angiotensin II stimulates angiotensin sybtype 2 (AT2) receptor [HSA:186] [KO:K04167]
     Angiotensin II (human type)
      D02014  Angiotensin II (human type) (JAN)
BRITE hierarchy
Other DBs
CAS: 
4474-91-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        75
            1   C1c C    12.7036  -15.5584
            2   N1b N    11.5241  -14.8774
            3   C5a C    10.3446  -15.5584
            4   C1c C     9.1630  -14.8762
            5   O5a O    10.3446  -16.9235
            6   C1b C     7.9792  -15.5597
            7   N1a N     9.1630  -13.5176
            8   C6a C     6.8000  -14.8789
            9   O6a O     5.6186  -15.5610
            10  O6a O     6.8001  -13.5176
            11  C1b C    12.7037  -16.9235
            12  C1b C    13.8823  -17.6039
            13  C1b C    13.8821  -18.9681
            14  N1b N    15.0611  -19.6507
            15  C2c C    15.0595  -21.0131
            16  N1a N    16.2385  -21.6957
            17  N2a N    13.8831  -21.6904
            18  C1y C    30.4690  -15.5450
            19  N1y N    29.1255  -15.5450
            20  C1x C    28.7105  -16.8227
            21  C1x C    29.7973  -17.6124
            22  C1x C    30.8843  -16.8227
            23  C5a C    27.9621  -14.8733
            24  C1c C    26.7987  -15.5450
            25  N1b N    25.6353  -14.8733
            26  C5a C    24.4718  -15.5450
            27  C1c C    23.3083  -14.8733
            28  N1b N    22.1450  -15.5450
            29  C5a C    20.9814  -14.8733
            30  O5a O    27.9621  -13.5299
            31  C1b C    26.7987  -18.9480
            32  C8y C    27.9657  -19.6217
            33  C8x C    28.1064  -20.9602
            34  N5x N    29.4227  -21.2401
            35  C8x C    30.0957  -20.0746
            36  N4x N    29.1951  -19.0745
            37  O5a O    24.4718  -16.8919
            38  C1c C    23.3083  -12.8491
            39  C1b C    24.4734  -12.1764
            40  C1a C    22.1458  -12.1779
            41  C1a C    24.4734  -10.8331
            42  C1c C    19.7856  -15.5639
            43  O5a O    20.9813  -13.5155
            44  N1b N    18.6005  -14.8799
            45  C5a C    17.4216  -15.5584
            46  C1c C    16.2421  -14.8774
            47  N1b N    15.0627  -15.5584
            48  C5a C    13.8832  -14.8774
            49  O5a O    17.4207  -16.9203
            50  C1c C    16.2421  -12.9687
            51  C1a C    15.0614  -12.2869
            52  C1a C    17.4203  -12.2885
            53  O5a O    13.8832  -13.5154
            54  C1b C    19.7857  -17.2661
            55  C8y C    20.9671  -17.9480
            56  C8x C    20.9672  -19.3097
            57  C8x C    22.1471  -19.9908
            58  C8y C    23.3270  -19.3095
            59  C8x C    23.3268  -17.9478
            60  C8x C    22.1468  -17.2667
            61  O1a O    24.5242  -20.0008
            62  C5a C    31.6325  -14.8733
            63  N1b N    32.7960  -15.5450
            64  C1c C    33.9594  -14.8733
            65  C1b C    35.1229  -15.5450
            66  O5a O    31.6325  -13.5299
            67  C8y C    36.2890  -14.8718
            68  C8x C    37.4544  -15.5447
            69  C8x C    38.6179  -14.8730
            70  C8x C    38.6179  -13.5295
            71  C8x C    37.4525  -12.8566
            72  C8x C    36.2890  -13.5284
            73  C6a C    33.9594  -13.5299
            74  O6a O    35.1249  -12.8570
            75  O6a O    32.7979  -12.8593
BOND        78
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 2
            5     4   6 1
            6     4   7 1 #Down
            7     6   8 1
            8     8   9 1
            9     8  10 2
            10    1  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   15  17 2
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   18  22 1
            22   19  23 1
            23   23  24 1
            24   24  25 1
            25   25  26 1
            26   26  27 1
            27   27  28 1 #Up
            28   28  29 1
            29   23  30 2
            30   24  31 1 #Down
            31   31  32 1
            32   32  33 2
            33   33  34 1
            34   34  35 2
            35   35  36 1
            36   32  36 1
            37   26  37 2
            38   27  38 1
            39   38  39 1
            40   38  40 1 #Up
            41   39  41 1
            42   29  42 1
            43   29  43 2
            44   42  44 1 #Down
            45   44  45 1
            46   45  46 1
            47   46  47 1 #Up
            48   47  48 1
            49   45  49 2
            50   46  50 1
            51   50  51 1
            52   50  52 1
            53   48  53 2
            54   42  54 1
            55   54  55 1
            56   55  56 2
            57   56  57 1
            58   57  58 2
            59   58  59 1
            60   59  60 2
            61   55  60 1
            62   58  61 1
            63    1  48 1 #Down
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   62  66 2
            68   65  67 1
            69   67  68 2
            70   68  69 1
            71   69  70 2
            72   70  71 1
            73   71  72 2
            74   67  72 1
            75   73  74 1
            76   73  75 2
            77   64  73 1 #Down
            78   18  62 1 #Down

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