KEGG   DRUG: D02016Help
Entry
D02016                      Drug                                   

Name
Ramosetron hydrochloride (JAN);
YM 060;
Nasea (TN)
Formula
C17H17N3O. HCl
Exact mass
315.1138
Mol weight
315.7973
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Serotonin antagonist
Remark
Therapeutic category: 
Target
5-HT3 receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A1 [HSA:1543], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Serotonin receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D02016  Ramosetron hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT3-receptor
     Ramosetron
      D02016  Ramosetron hydrochloride (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A1
   Ramosetron
    D02016  Ramosetron hydrochloride (JAN)
  CYP1A2
   Ramosetron
    D02016  Ramosetron hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
132907-72-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   X   Cl   21.3413   -6.1250
            2   C1x C    12.9500   -3.9900
            3   C1y C    12.9500   -5.3900
            4   C5a C    14.1624   -6.0900
            5   C8y C    15.3749   -5.3900
            6   C8x C    15.3749   -3.9900
            7   C1x C    11.7376   -3.2900
            8   C8y C    10.5251   -3.9900
            9   C8y C    10.5251   -5.3900
            10  C1x C    11.7376   -6.0900
            11  C8y C    16.7064   -5.8226
            12  C8y C    17.5293   -4.6900
            13  N4y N    16.7064   -3.5574
            14  C8x C    17.2758   -7.1016
            15  C8x C    18.6681   -7.2479
            16  C8x C    19.4911   -6.1153
            17  C8x C    18.9216   -4.8363
            18  O5a O    14.1624   -7.4900
            19  N5x N     9.1936   -3.5574
            20  C8x C     8.3707   -4.6900
            21  N4x N     9.1936   -5.8226
            22  C1a C    17.4064   -2.3449
BOND        24
            1     2   3 1
            2     3   4 1 #Up
            3     4   5 1
            4     5   6 2
            5     2   7 1
            6     7   8 1
            7     8   9 2
            8     9  10 1
            9     3  10 1
            10    5  11 1
            11   11  12 2
            12   12  13 1
            13    6  13 1
            14   11  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19    4  18 2
            20    8  19 1
            21   19  20 2
            22   20  21 1
            23    9  21 1
            24   13  22 1

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