KEGG   DRUG: D02037Help
Entry
D02037                      Drug                                   

Name
Perphenazine maleate (JP16);
PZC (TN)
Formula
C21H26ClN3OS. (C4H4O4)2
Exact mass
635.1704
Mol weight
636.113
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Phenothiazine derivatives
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB03 Perphenazine
      D02037  Perphenazine maleate (JP16)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Perphenazine
    D02037  Perphenazine maleate (JP16)
 Antipsychotics
  1st Generation/Typical
   Perphenazine
    D02037  Perphenazine maleate (JP16)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D02037  Perphenazine maleate (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Perphenazine
      D02037  Perphenazine maleate (JP16)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Perphenazine
    D02037  Perphenazine maleate (JP16)
 Inhbitors
  CYP2D6
   Perphenazine
    D02037  Perphenazine maleate (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02037  Perphenazine maleate
  D02037  Perphenazine maleate tablets
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        43
            1   C8x C    22.5990  -18.4898
            2   C8x C    22.5990  -19.8851
            3   C8x C    23.7851  -20.5828
            4   C8y C    25.0409  -19.8851
            5   C8y C    25.0409  -18.4898
            6   C8x C    23.7851  -17.7224
            7   S2x S    26.2269  -20.5828
            8   C8y C    27.4129  -19.8851
            9   C8y C    27.4129  -18.4898
            10  N4y N    26.2269  -17.7224
            11  C8x C    28.6687  -20.5828
            12  C8x C    29.8548  -19.8851
            13  C8y C    29.8548  -18.4898
            14  C8x C    28.6687  -17.7224
            15  C1b C    26.2269  -16.3270
            16  C1b C    27.4129  -15.6294
            17  C1b C    28.5990  -16.3270
            18  N1y N    29.7850  -15.6294
            19  C1x C    30.9710  -16.3270
            20  C1x C    32.2268  -15.6294
            21  N1y N    32.2268  -14.2340
            22  C1x C    31.0408  -13.5364
            23  C1x C    29.7850  -14.2340
            24  C1b C    33.4129  -13.5364
            25  C1b C    34.5989  -14.2340
            26  O1a O    35.7850  -13.5364
            27  X   Cl   31.0408  -17.7224
            28  C6a C    38.7336  -18.9644
            29  C2b C    38.0607  -17.8036
            30  O6a O    38.1360  -20.2005
            31  O6a O    40.0797  -18.9581
            32  C2b C    36.4492  -17.8098
            33  C6a C    35.7825  -18.9767
            34  O6a O    34.4364  -18.9767
            35  O6a O    36.4617  -20.2066
            36  C6a C    38.7336  -18.9644
            37  C2b C    38.0607  -17.8036
            38  C2b C    36.4492  -17.8098
            39  C6a C    35.7825  -18.9767
            40  O6a O    34.4364  -18.9767
            41  O6a O    36.4617  -20.2066
            42  O6a O    38.1360  -20.2005
            43  O6a O    40.0797  -18.9581
BOND        44
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   18  23 1
            27   21  24 1
            28   24  25 1
            29   25  26 1
            30   13  27 1
            31   28  29 1
            32   28  30 1
            33   28  31 2
            34   29  32 2
            35   32  33 1
            36   33  34 1
            37   33  35 2
            38   36  37 1
            39   36  42 1
            40   36  43 2
            41   37  38 2
            42   38  39 1
            43   39  40 1
            44   39  41 2
BRACKET     1    33.3200  -20.8600   33.3200  -17.1500
            1    40.8100  -17.1500   40.8100  -20.8600
            1  2
 ORIGINAL  1   28  29  32  33  34  35  30  31
 REPEAT    1   36  37  38  39  40  41  42  43

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