KEGG   DRUG: D02041Help
Entry
D02041                      Drug                                   

Name
Tropisetron hydrochloride (JAN);
Navoban (TN)
Formula
C17H20N2O2. HCl
Exact mass
320.1292
Mol weight
320.8138
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-emetic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819]
  Pathway
hsa04726  Serotonergic synapse  
 
Interaction
Drug interaction
Structure map
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA03 Tropisetron
      D02041  Tropisetron hydrochloride (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D02041  Tropisetron hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT3-receptor
     Tropisetron
      D02041  Tropisetron hydrochloride (JAN)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D02041  Tropisetron hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
105826-92-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   X   Cl   38.5928  -17.3129
            2   O7a O    30.1000  -18.9700
            3   C1y C    28.9800  -18.3400
            4   C1x C    28.0000  -16.8700
            5   C1x C    28.0000  -17.8500
            6   C1y C    26.5300  -16.8700
            7   C1y C    26.4600  -17.8500
            8   N1y N    25.6900  -15.8900
            9   C1x C    25.5500  -17.4300
            10  C1x C    24.9900  -18.4800
            11  C1a C    25.6900  -14.5600
            12  C7a C    31.5000  -18.9700
            13  C8y C    32.2000  -17.7100
            14  O6a O    32.2000  -20.2300
            15  C8y C    33.6000  -17.7100
            16  C8y C    33.8800  -16.3100
            17  N4x N    32.6900  -15.6100
            18  C8x C    31.6400  -16.5200
            19  C8x C    34.6500  -18.6200
            20  C8x C    35.9800  -18.2000
            21  C8x C    36.2600  -16.8700
            22  C8x C    35.2800  -15.8900
BOND        24
            1     3   5 1
            2     4   6 1
            3     5   7 1
            4     6   8 1
            5     6   9 1
            6     7  10 1
            7     7   8 1
            8     9  10 1
            9     3   2 1 #Down
            10    3   4 1
            11    8  11 1
            12    2  12 1
            13   12  13 1
            14   12  14 2
            15   13  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 2
            20   15  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   16  22 2

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