KEGG   DRUG: Tacrine hydrochlorideHelp
Entry
D02068                      Drug                                   

Name
Tacrine hydrochloride (USP);
Cognex (TN)
Formula
C13H14N2. HCl
Exact mass
234.0924
Mol weight
234.7246
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
Unclassified
Remark
ATC code: 
Chemical group: 
Activity
Nootropic, Acetylcholinesterase inhibitor
Comment
Cognition adjuvant, Dementia symptoms treatment adjunct
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA01 Tacrine
      D02068  Tacrine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Tacrine
     D02068  Tacrine hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Tacrine
    D02068  Tacrine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
1684-40-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    30.8048  -18.5255
            2   C8y C    30.8048  -17.1322
            3   N5x N    32.0124  -19.2221
            4   C8x C    29.5974  -19.2221
            5   C8y C    32.0124  -16.4356
            6   C8x C    29.5974  -16.4356
            7   C8y C    33.2199  -18.5255
            8   C8x C    28.3897  -18.5255
            9   C8y C    33.2199  -17.1322
            10  N1a N    32.0124  -15.0887
            11  C8x C    28.3897  -17.1322
            12  C1x C    34.4275  -19.2221
            13  C1x C    34.4275  -16.3892
            14  C1x C    35.6814  -18.5255
            15  C1x C    35.6816  -17.0858
            16  X   Cl   38.3993  -17.5338
BOND        17
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   13  15 1
            15    7   9 1
            16    8  11 1
            17   14  15 1

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