KEGG   DRUG: D02068Help
Entry
D02068                      Drug                                   

Name
Tacrine hydrochloride (USP);
Cognex (TN)
Formula
C13H14N2. HCl
Exact mass
234.0924
Mol weight
234.7246
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cognition adjuvant;
Dementia symptoms treatment adjunct
Remark
ATC code: 
Drug group: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA01 Tacrine
      D02068  Tacrine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Tacrine
     D02068  Tacrine hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Tacrine
    D02068  Tacrine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
1684-40-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    30.8048  -18.5255
            2   C8y C    30.8048  -17.1322
            3   N5x N    32.0124  -19.2221
            4   C8x C    29.5974  -19.2221
            5   C8y C    32.0124  -16.4356
            6   C8x C    29.5974  -16.4356
            7   C8y C    33.2199  -18.5255
            8   C8x C    28.3897  -18.5255
            9   C8y C    33.2199  -17.1322
            10  N1a N    32.0124  -15.0887
            11  C8x C    28.3897  -17.1322
            12  C1x C    34.4275  -19.2221
            13  C1x C    34.4275  -16.3892
            14  C1x C    35.6814  -18.5255
            15  C1x C    35.6816  -17.0858
            16  X   Cl   38.3993  -17.5338
BOND        17
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   13  15 1
            15    7   9 1
            16    8  11 1
            17   14  15 1

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