KEGG   DRUG: D02069Help
Entry
D02069                      Drug                                   

Name
Atropine sulfate (JP16/USP);
Isopto Atropine (TN)
Product
  Other
ATROPINE SULFATE (A-S Medication Solutions LLC), ATROPINE SULFATE (Akorn), ISOPTO ATROPINE (Alcon Laboratories), ATROPINE SULFATE (Alcon Laboratories), ATROPINE SULFATE (American Regent), ATROPINE SULFATE (Amphastar Pharmaceuticals), ATROPINE SULFATE (Bausch & Lomb Incorporated), ATROPINE SULFATE (Bausch & Lomb Incorporated), ATROPINE SULFATE (Cardinal Health), ATROPINE SULFATE (Cardinal Health), ATROPINE SULFATE (FALCON LABORATORY), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (General Injectables & Vaccines), ATROPINE SULFATE (Hospira), ATROPINE SULFATE (International Medication Systems), ATROPINE SULFATE (West-ward Pharmaceutical Corp.)
Formula
(C17H23NO3)2. H2SO4. H2O
Exact mass
694.3135
Mol weight
694.8326
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic [ophthalmic]
Remark
Therapeutic category: 
ATC code: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1242  Atropines
     D02069  Atropine sulfate (JP16/USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1311  Mydriatic agents
     D02069  Atropine sulfate (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03B BELLADONNA AND DERIVATIVES, PLAIN
    A03BA Belladonna alkaloids, tertiary amines
     A03BA01 Atropine
      D02069  Atropine sulfate (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA01 Atropine
      D02069  Atropine sulfate (JP16/USP)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Atropine
    D02069  Atropine sulfate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
     Atropine [ATC:A03BA01 S01FA01]
      D02069  Atropine sulfate (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
5908-99-6
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        48
            1   S4a S    30.5665  -18.3867
            2   O1d O    30.5665  -16.9867
            3   O1d O    30.5665  -19.7867
            4   O1d O    31.9665  -18.3867
            5   O1d O    29.1666  -18.3867
            6   O0  O    36.2599  -18.3400
            7   C1x C    15.7738  -18.5308
            8   C1x C    16.1019  -17.3591
            9   C1y C    16.9455  -18.2496
            10  C1y C    17.2736  -17.0779
            11  N1y N    16.0082  -15.7656
            12  C1x C    18.8202  -18.2496
            13  C1x C    18.5390  -17.0779
            14  C1y C    19.8513  -18.8120
            15  O7a O    20.9293  -19.7025
            16  C7a C    22.1479  -19.7025
            17  C1c C    22.7572  -18.6245
            18  O6a O    22.7572  -20.8273
            19  C8y C    23.9758  -18.6245
            20  C1b C    22.1479  -17.5934
            21  O1a O    22.7572  -16.5155
            22  C8x C    24.6820  -19.8482
            23  C8x C    26.0820  -19.8485
            24  C8x C    26.7822  -18.6362
            25  C8x C    26.0761  -17.4125
            26  C8x C    24.6761  -17.4122
            27  C1a C    15.2591  -14.5814
            28  C1x C    15.7738  -18.5308
            29  C1x C    16.1019  -17.3591
            30  C1y C    17.2736  -17.0779
            31  C1x C    18.5390  -17.0779
            32  C1y C    19.8513  -18.8120
            33  C1x C    18.8202  -18.2496
            34  C1y C    16.9455  -18.2496
            35  N1y N    16.0082  -15.7656
            36  C1a C    15.2591  -14.5814
            37  O7a O    20.9293  -19.7025
            38  C7a C    22.1479  -19.7025
            39  C1c C    22.7572  -18.6245
            40  C8y C    23.9758  -18.6245
            41  C8x C    24.6820  -19.8482
            42  C8x C    26.0820  -19.8485
            43  C8x C    26.7822  -18.6362
            44  C8x C    26.0761  -17.4125
            45  C8x C    24.6761  -17.4122
            46  C1b C    22.1479  -17.5934
            47  O1a O    22.7572  -16.5155
            48  O6a O    22.7572  -20.8273
BOND        50
            1     1   2 2
            2     1   3 2
            3     1   4 1
            4     1   5 1
            5     7   8 1
            6     7   9 1
            7     8  10 1
            8     9  11 1
            9     9  12 1
            10   10  13 1
            11   12  14 1
            12   14  15 1 #Down
            13   15  16 1
            14   16  17 1
            15   16  18 2
            16   17  19 1
            17   17  20 1
            18   20  21 1
            19   10  11 1
            20   13  14 1
            21   19  22 2
            22   22  23 1
            23   23  24 2
            24   24  25 1
            25   25  26 2
            26   19  26 1
            27   11  27 1
            28   28  29 1
            29   28  34 1
            30   29  30 1
            31   34  35 1
            32   34  33 1
            33   30  31 1
            34   33  32 1
            35   32  37 1 #Down
            36   37  38 1
            37   38  39 1
            38   38  48 2
            39   39  40 1
            40   39  46 1
            41   46  47 1
            42   30  35 1
            43   31  32 1
            44   40  41 2
            45   41  42 1
            46   42  43 2
            47   43  44 1
            48   44  45 2
            49   40  45 1
            50   35  36 1
BRACKET     1    13.2300  -21.3500   13.2300  -13.7200
            1    27.0900  -13.7200   27.0900  -21.3500
            1  2
 ORIGINAL  1    7   8  10  13  14  12   9  11  29  22  15  16  17  19  24  25
            1   26  27  28  20  21  18  23
 REPEAT    1   30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45
            1   46  47  48  49  50  51  52

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