KEGG   DRUG: D02071Help
Entry
D02071                      Drug                                   

Name
Scopolamine hydrobromide hydrate (JP16);
Scopolamine hydrobromide (USP);
Scopolamine hydrobromide trihydrate;
Hysco (TN);
Isopto hyoscine (TN)
Product
  Other
Formula
C17H21NO4. 3H2O. HBr
Exact mass
437.1049
Mol weight
438.3107
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic [ophthalmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AD Other antiemetics
     A04AD01 Scopolamine
      D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CM Other hypnotics and sedatives
     N05CM05 Scopolamine
      D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA02 Scopolamine
      D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Scopolamine
    D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1242  Atropines
     D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Scopolamine
    D02071  Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Scopolamine
      D02071  Scopolamine hydrobromide (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02071  Scopolamine hydrobromide hydrate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D02071  Scopolamine hydrobromide (JP15/USP)
BRITE hierarchy
Other DBs
CAS: 
6533-68-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   X   Br   38.4301  -16.1700
            2   O0  O    38.8500  -18.6900
            3   C1y C    24.3600  -17.8500
            4   C1y C    24.6400  -16.6600
            5   C1y C    25.4800  -17.5700
            6   O2x O    23.3100  -16.4500
            7   C1y C    25.8300  -16.3800
            8   N1y N    24.5700  -15.0500
            9   C1x C    27.3700  -17.5700
            10  C1x C    27.0900  -16.3800
            11  C1a C    24.5700  -13.7200
            12  C1y C    28.3500  -18.0600
            13  O7a O    29.4000  -18.9700
            14  C7a C    30.8000  -18.9700
            15  O6a O    31.5000  -20.1600
            16  C1c C    31.5000  -17.7800
            17  C8y C    32.9000  -17.7800
            18  C8x C    33.6000  -18.9700
            19  C8x C    35.0000  -18.9700
            20  C8x C    35.7000  -17.7800
            21  C8x C    35.0000  -16.5900
            22  C8x C    33.6000  -16.5900
            23  C1b C    30.8000  -16.5200
            24  O1a O    31.5000  -15.3300
            25  O0  O    38.8500  -18.6900
            26  O0  O    38.8500  -18.6900
BOND        25
            1     3   4 1
            2     3   5 1
            3     3   6 1
            4     4   7 1
            5     5   8 1
            6     5   9 1
            7     7  10 1
            8     8  11 1
            9     9  12 1
            10   12  13 1 #Down
            11    4   6 1
            12    7   8 1
            13   10  12 1
            14   13  14 1
            15   14  15 2
            16   14  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   17  22 1
            24   16  23 1 #Down
            25   23  24 1
BRACKET     1    36.8200  -19.8100   36.8200  -17.6400
            1    39.4100  -17.6400   39.4100  -19.8100
            1  3
 ORIGINAL  1    2
 REPEAT    1   27  28

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