KEGG   DRUG: Scopolamine hydrobromideHelp
Entry
D02071                      Drug                                   

Name
Scopolamine hydrobromide (USP);
Scopolamine hydrobromide hydrate (JP17);
Scopolamine hydrobromide trihydrate;
Hysco (TN);
Isopto hyoscine (TN)
Product
  Other
Formula
C17H21NO4. 3H2O. HBr
Exact mass
437.1049
Mol weight
438.3107
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Gastrointestinal agent
 DG01762  Antiemetic
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antispasmodic, Midriatic, Anticholinergic
Comment
Tropane derivative
Target
muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AD Other antiemetics
     A04AD01 Scopolamine
      D02071  Scopolamine hydrobromide (USP)
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CM Other hypnotics and sedatives
     N05CM05 Scopolamine
      D02071  Scopolamine hydrobromide (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA02 Scopolamine
      D02071  Scopolamine hydrobromide (USP)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Scopolamine
    D02071  Scopolamine hydrobromide (USP)
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Scopolamine
    D02071  Scopolamine hydrobromide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1242  Atropines
     D02071  Scopolamine hydrobromide (USP); Scopolamine hydrobromide hydrate (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D02071  Scopolamine hydrobromide (USP)
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D02071  Scopolamine hydrobromide (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Scopolamine
    D02071  Scopolamine hydrobromide (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Scopolamine
      D02071  Scopolamine hydrobromide (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02071  Scopolamine hydrobromide hydrate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D02071  Scopolamine hydrobromide (JP15/USP)
BRITE hierarchy
Other DBs
CAS: 
6533-68-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   X   Br   38.4301  -16.1700
            2   O0  O    38.8500  -18.6900
            3   C1y C    24.3600  -17.8500
            4   C1y C    24.6400  -16.6600
            5   C1y C    25.4800  -17.5700
            6   O2x O    23.3100  -16.4500
            7   C1y C    25.8300  -16.3800
            8   N1y N    24.5700  -15.0500
            9   C1x C    27.3700  -17.5700
            10  C1x C    27.0900  -16.3800
            11  C1a C    24.5700  -13.7200
            12  C1y C    28.3500  -18.0600
            13  O7a O    29.4000  -18.9700
            14  C7a C    30.8000  -18.9700
            15  O6a O    31.5000  -20.1600
            16  C1c C    31.5000  -17.7800
            17  C8y C    32.9000  -17.7800
            18  C8x C    33.6000  -18.9700
            19  C8x C    35.0000  -18.9700
            20  C8x C    35.7000  -17.7800
            21  C8x C    35.0000  -16.5900
            22  C8x C    33.6000  -16.5900
            23  C1b C    30.8000  -16.5200
            24  O1a O    31.5000  -15.3300
            25  O0  O    38.8500  -18.6900
            26  O0  O    38.8500  -18.6900
BOND        25
            1     3   4 1
            2     3   5 1
            3     3   6 1
            4     4   7 1
            5     5   8 1
            6     5   9 1
            7     7  10 1
            8     8  11 1
            9     9  12 1
            10   12  13 1 #Down
            11    4   6 1
            12    7   8 1
            13   10  12 1
            14   13  14 1
            15   14  15 2
            16   14  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   17  22 1
            24   16  23 1 #Down
            25   23  24 1
BRACKET     1    36.8200  -19.8100   36.8200  -17.6400
            1    39.4100  -17.6400   39.4100  -19.8100
            1  3
 ORIGINAL  1    2
 REPEAT    1   27  28

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