KEGG   DRUG: D02074Help
Entry
D02074                      Drug                                   

Name
Amphetamine sulfate (USP);
Benzedrine (TN)
Formula
(C9H13N)2. H2SO4
Exact mass
368.177
Mol weight
368.4909
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Stimulant [central]
Remark
ATC code: 
Drug group: 
Target
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035];
dopamine transporter inhibitor [HSA:6531] [KO:K05036];
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA01 Amfetamine
      D02074  Amphetamine sulfate (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Amfetamine
      D02074  Amphetamine sulfate (USP)
    SLC6A3 (dopamine transporter)
     Amfetamine
      D02074  Amphetamine sulfate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Amfetamine
    D02074  Amphetamine sulfate (USP)
BRITE hierarchy
Other DBs
CAS: 
60-13-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    21.4900  -16.1000
            2   C8x C    20.3000  -15.4000
            3   C8x C    21.4900  -17.5000
            4   C1b C    22.6800  -15.4000
            5   C8x C    19.0400  -16.1000
            6   C8x C    20.3000  -18.2000
            7   C1c C    23.9400  -16.1000
            8   C8x C    19.0400  -17.5000
            9   C1a C    25.1300  -15.4000
            10  N1a N    23.9400  -17.5000
            11  S4a S    30.3800  -16.6600
            12  O1d O    30.3800  -15.2600
            13  O1d O    30.3800  -18.0600
            14  O1d O    31.7800  -16.6600
            15  O1d O    28.9800  -16.6600
            16  C8y C    21.4900  -16.1000
            17  C8x C    20.3000  -15.4000
            18  C8x C    19.0400  -16.1000
            19  C8x C    19.0400  -17.5000
            20  C8x C    20.3000  -18.2000
            21  C8x C    21.4900  -17.5000
            22  C1b C    22.6800  -15.4000
            23  C1c C    23.9400  -16.1000
            24  C1a C    25.1300  -15.4000
            25  N1a N    23.9400  -17.5000
BOND        24
            1    11  12 2
            2    11  13 2
            3    11  14 1
            4    11  15 1
            5     1   2 2
            6     1   3 1
            7     1   4 1
            8     2   5 1
            9     3   6 2
            10    4   7 1
            11    5   8 2
            12    7   9 1
            13    7  10 1
            14    6   8 1
            15   16  17 2
            16   16  21 1
            17   16  22 1
            18   17  18 1
            19   21  20 2
            20   22  23 1
            21   18  19 2
            22   23  24 1
            23   23  25 1
            24   20  19 1
BRACKET     1    18.4800  -19.2500   18.4800  -14.3500
            1    26.6700  -14.3500   26.6700  -19.2500
            1  2
 ORIGINAL  1    1   2   5   8   6   3   4   7   9  10
 REPEAT    1   16  17  18  19  20  21  22  23  24  25

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