KEGG   DRUG: D02078Help
Entry
D02078                      Drug                                   

Name
Dextroamphetamine sulfate (USP);
Dexedrine (TN);
Dextrostat (TN)
Product
  Generic
DEXTROAMPHETAMINE (Tris Pharma), DEXTROAMPHETAMINE SULFATE (Actavis), DEXEDRINE (Amedra Pharmaceuticals LLC), ZENZEDI (Arbor Pharmaceuticals), ZENZEDI (Arbor Pharmaceuticals), DEXTROAMPHETAMINE SULFATE (Aurolife Pharma), DEXTROAMPHETAMINE SULFATE (Barr Laboratories), DEXTROAMPHETAMINE SULFATE (Barr Laboratories), DEXTROAMPHETAMINE SULFATE (CorePharma), DEXTROAMPHETAMINE SULFATE (Ethex Corporation), PROCENTRA (FSC Laboratories), PROCENTRA (Independence Pharmaceuticals), DEXTROAMPHETAMINE SULFATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DEXTROAMPHETAMINE SULFATE (Lineage Therapeutics), DEXTROAMPHETAMINE SULFATE (Mallinckrodt), DEXTROAMPHETAMINE SULFATE (Mallinckrodt), DEXTROAMPHETAMINE SULFATE (Physicians Total Care), DEXTROAMPHETAMINE SULFATE (Talec Pharma), DEXTROAMPHETAMINE SULFATE (Wilshire Pharmaceuticals)
Formula
(C9H13N)2. H2SO4
Exact mass
368.177
Mol weight
368.4909
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Stimulant [central]
Remark
ATC code: 
Drug group: 
Comment
Indicatitons: Narcolepsy, Attention deficit hyperactivity disorder, etc.
Target
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035];
dopamine transporter inhibitor [HSA:6531] [KO:K05036];
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA02 Dexamfetamine
      D02078  Dextroamphetamine sulfate (USP)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Dextroamphetamine
    D02078  Dextroamphetamine sulfate (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Dexamfetamine
      D02078  Dextroamphetamine sulfate (USP)
    SLC6A3 (dopamine transporter)
     Dexamfetamine
      D02078  Dextroamphetamine sulfate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Dexamfetamine
    D02078  Dextroamphetamine sulfate (USP)
BRITE hierarchy
Other DBs
CAS: 
51-63-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    24.7800  -14.3500
            2   C8x C    23.5900  -13.6500
            3   C8x C    24.7800  -15.7500
            4   C1b C    25.9700  -13.6500
            5   C8x C    22.3300  -14.3500
            6   C8x C    23.5900  -16.4500
            7   C1c C    27.2300  -14.3500
            8   C8x C    22.3300  -15.7500
            9   C1a C    28.4200  -13.6500
            10  N1a N    27.2300  -15.7500
            11  S4a S    33.6700  -14.9100
            12  O1d O    33.6700  -13.5100
            13  O1d O    33.6700  -16.3100
            14  O1d O    35.0700  -14.9100
            15  O1d O    32.2700  -14.9100
            16  C8y C    24.7800  -14.3500
            17  C8x C    23.5900  -13.6500
            18  C8x C    22.3300  -14.3500
            19  C8x C    22.3300  -15.7500
            20  C8x C    23.5900  -16.4500
            21  C8x C    24.7800  -15.7500
            22  C1b C    25.9700  -13.6500
            23  C1c C    27.2300  -14.3500
            24  C1a C    28.4200  -13.6500
            25  N1a N    27.2300  -15.7500
BOND        24
            1    11  12 2
            2    11  13 2
            3    11  14 1
            4    11  15 1
            5     1   2 2
            6     1   3 1
            7     1   4 1
            8     2   5 1
            9     3   6 2
            10    4   7 1
            11    5   8 2
            12    7   9 1
            13    7  10 1 #Down
            14    6   8 1
            15   16  17 2
            16   16  21 1
            17   16  22 1
            18   17  18 1
            19   21  20 2
            20   22  23 1
            21   18  19 2
            22   23  24 1
            23   23  25 1 #Down
            24   20  19 1
BRACKET     1    21.7000  -17.4300   21.7000  -12.5300
            1    29.8900  -12.5300   29.8900  -17.4300
            1  2
 ORIGINAL  1    1   2   5   8   6   3   4   7   9  10
 REPEAT    1   16  17  18  19  20  21  22  23  24  25

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