KEGG   DRUG: D02081Help
Entry
D02081                      Drug                                   

Name
Metipranolol hydrochloride;
Optipranolol (TN)
Formula
C17H27NO4. HCl
Exact mass
345.1707
Mol weight
345.8615
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED04 Metipranolol
      D02081  Metipranolol hydrochloride
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Metipranolol
    D02081  Metipranolol hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Metipranolol
      D02081  Metipranolol hydrochloride
    beta2-adrenergic receptor
     Metipranolol
      D02081  Metipranolol hydrochloride
    beta3-adrenergic receptor
     Metipranolol
      D02081  Metipranolol hydrochloride
BRITE hierarchy
Other DBs
CAS: 
36592-77-5
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        23
            1   X   Cl   23.7924  -31.0632
            2   O2a O    16.8700  -25.3400
            3   C1b C    18.0600  -24.6400
            4   C1c C    19.1800  -25.3400
            5   C1b C    20.3700  -24.6400
            6   O1a O    19.1800  -26.7400
            7   N1b N    21.5600  -25.3400
            8   C1c C    22.7500  -24.6400
            9   C1a C    24.0100  -25.3400
            10  C1a C    22.7500  -23.1700
            11  C8y C    16.8700  -26.7400
            12  C8y C    15.6576  -27.4400
            13  C8y C    15.6576  -28.8400
            14  C8y C    16.8700  -29.5400
            15  C8y C    18.0824  -28.8400
            16  C8x C    18.0824  -27.4400
            17  C1a C    19.2779  -29.5304
            18  O7a O    16.8700  -30.9400
            19  C7a C    15.6576  -31.6400
            20  C1a C    14.4621  -29.5304
            21  C1a C    14.4621  -30.9496
            22  O6a O    15.6575  -33.0398
            23  C1a C    14.4621  -26.7496
BOND        22
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     4   6 1
            5     5   7 1
            6     7   8 1
            7     8   9 1
            8     8  10 1
            9     2  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13   14  15 1
            14   15  16 2
            15   11  16 1
            16   15  17 1
            17   14  18 1
            18   18  19 1
            19   13  20 1
            20   19  21 1
            21   19  22 2
            22   12  23 1

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