KEGG   DRUG: Lidocaine hydrochlorideHelp
Entry
D02086                      Drug                                   

Name
Lidocaine hydrochloride (JAN/USP);
Lidocaine injection (JP17);
Dalcaine (TN);
Xylocaine (TN)
Product
XYLOCAINE (General Injectables & Vaccines), XYLOCAINE-MPF (APP Pharmaceuticals), XYLOCAINE (APP Pharmaceuticals), XYLOCAINE (APP Pharmaceuticals), LIDOCAINE (APP Pharmaceuticals), XYLOCAINE (APP Pharmaceuticals), AKTEN (Akorn), LIDOCAINE HYDROCHLORIDE AND DEXTROSE (Baxter Healthcare Corporation), LIDOCAINE (Cardinal Health), XYLOCAINE (Cardinal Health), XYLOCAINE (Cardinal Health), XYLOCAINE (Cardinal Health), XYLOCAINE (Cardinal Health), XYLOCAINE (Fresenius Kabi USA), XYLOCAINE (General Injectables & Vaccines), XYLOCAINE (General Injectables & Vaccines), XYLOCAINE (General Injectables & Vaccines), ZINGO (Medline Industries), XYLOCAINE (Oak Pharmaceuticals), XYLOCAINE (REMEDYREPACK), XYLOCAINE (REMEDYREPACK), XYLOCAINE (Rebel Distributors Corp), ZINGO (7T Pharma LLC), ZINGO (Powder Pharmaceuticals)
  Generic
LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccine), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE (General Injectables & Vaccines), LIDOCAINE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions LLC), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions LLC), LIDOCAINE HYDROCHLORIDE (AGILA SPECIALTIES PRIVATE LIMITED), LIDOCAINE (APP Pharmaceuticals), LIDOCAINE (APP Pharmaceuticals), LIDOCAINE (Actavis Pharma), LIDOCAINE (Akorn), LIDOCAINE (Akorn), LIDOCAINE (Akorn), LIDOCAINE HYDROCHLORIDE (Amphastar Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Amphastar Pharmaceuticals), LARYNG-O-JET (Amphastar Pharmaceuticals), ACCUCAINE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (Atlantic Biologicals Corps), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE VISCOUS (Cardinal Health), LIDOCAINE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Clinical Solutions Wholesale), LIDOCAINE HYDROCHLORIDE (DIRECT RX), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (Hi-Tech Pharmacal), ANESTACON (Hi-Tech Pharmacal), LIDOCAINE HYDROCHLORIDE (Hi-Tech Pharmacal), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (IGI Labs), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (LLC Federal Solutions), LIDOCAINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LIDOCAINE HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), LIDOCAINE HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), LIDOCAINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Mylan Institutional LLC), LIDOCAINE HYDROCHLORIDE (Mylan Institutional LLC), LIDOCAINE HYDROCHLORIDE (Physicians Total Care), LIDOCAINE (Physicians Total Care), LIDOCAINE HYDROCHLORIDE (Preferred Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Qualitest Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Qualitest Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (Rebel Distributors Corp), LIDOCAINE VISCOUS (Roxane Laboratories), LIDOCAINE HYDROCHLORIDE (STAT RX LLC USA), GLYDO (Sagent Pharmaceuticals), LIDOCAINE (US MedSource), LIDOCAINE HYDROCHLORIDE (Unit Dose Services), LIDOCAINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions LLC), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), LIDOCAINE HYDROCHLORIDE (Physicians Total Care), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (US MedSource), LIDOCAINE HYDROCHLORIDE (US MedSource), MEDICATED DNA COLLECTION KIT (TrueFit RX LLC), LIDOCAINE VISCOUS (Direct RX)
  Other
Formula
C14H22N2O. HCl
Exact mass
270.1499
Mol weight
270.7982
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Neuropsychiatric agent
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anesthetic (local), Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ib)
Anilide derivative
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841];
SCN10A [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Transporter: SLC22A3 [HSA:6581]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D02086  Lidocaine hydrochloride (JAN/USP); Lidocaine injection (JP17)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D02086  Lidocaine hydrochloride (JAN/USP); Lidocaine injection (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D02086  Lidocaine hydrochloride (JAN/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D02086  Lidocaine hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
Pharmaceutical additives [BR:br08316]
 Soothing agent
  D02086  [103841] Lidocaine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN2A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN3A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN4A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN5A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN8A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN9A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN10A)
     Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
  CYP2D6
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
  CYP3A4
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
 Transporter substrates
  SLC22A3
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
Cardiovascular agents [br08364.html]
 Antiarrhythmics
  D02086
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anesthetics
  D02086
BRITE hierarchy
Other DBs
CAS: 
73-78-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    27.4132  -17.1509
            2   N1b N    28.6465  -17.8641
            3   C8y C    26.1855  -17.8699
            4   C8y C    27.4132  -15.7304
            5   C5a C    29.8742  -17.1450
            6   C8x C    24.9579  -17.1509
            7   C1a C    26.1914  -19.2846
            8   C8x C    26.1855  -15.0230
            9   C1a C    28.6348  -15.0230
            10  C1b C    31.1017  -17.8641
            11  O5a O    29.9091  -16.0694
            12  C8x C    24.9579  -15.7304
            13  N1c N    32.3352  -17.1450
            14  C1b C    33.5686  -17.8641
            15  C1b C    32.3352  -15.7304
            16  C1a C    34.7845  -17.1450
            17  C1a C    33.5686  -15.0172
            18  X   Cl   39.1297  -16.5898
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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