KEGG   DRUG: D02086Help
Entry
D02086                      Drug                                   

Name
Lidocaine injection (JP16);
Lidocaine hydrochloride (JAN/USP);
Dalcaine (TN);
Xylocaine (TN)
Product
  Generic
LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccine), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions LLC), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions LLC), LIDOCAINE (APP Pharmaceuticals), LIDOCAINE (APP Pharmaceuticals), LIDOCAINE (Akorn), LIDOCAINE (Akorn), LIDOCAINE (Akorn), LIDOCAINE HYDROCHLORIDE (Amphastar Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Amphastar Pharmaceuticals), LARYNG-O-JET (Amphastar Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Atlantic Biologicals Corps), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE VISCOUS (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Clinical Solutions Wholesale), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (Hi-Tech Pharmacal), ANESTACON (Hi-Tech Pharmacal), LIDOCAINE HYDROCHLORIDE (Hi-Tech Pharmacal), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (LLC Federal Solutions), LIDOCAINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LIDOCAINE HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), LIDOCAINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Physicians Total Care), LIDOCAINE (Physicians Total Care), LIDOCAINE HYDROCHLORIDE (Preferred Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Qualitest Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Qualitest Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (Rebel Distributors Corp), LIDOCAINE VISCOUS (Roxane Laboratories), LIDOCAINE HYDROCHLORIDE (Roxane Laboratories), LIDOCAINE HYDROCHLORIDE (STAT RX LLC USA), LIDOCAINE HYDROCHLORIDE (Teva Pharmaceuticals USA), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions LLC), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), LIDOCAINE HYDROCHLORIDE (Physicians Total Care), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE VISCOUS (Direct RX)
  Other
Formula
C14H22N2O. HCl
Exact mass
270.1499
Mol weight
270.7982
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [local]
Remark
Comment
Class I antiarrhythmic agent
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Transporter: SLC22A3 [HSA:6581]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D02086  Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
    voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D02086  Lidocaine hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
73-78-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    27.4132  -17.1509
            2   N1b N    28.6465  -17.8641
            3   C8y C    26.1855  -17.8699
            4   C8y C    27.4132  -15.7304
            5   C5a C    29.8742  -17.1450
            6   C8x C    24.9579  -17.1509
            7   C1a C    26.1914  -19.2846
            8   C8x C    26.1855  -15.0230
            9   C1a C    28.6348  -15.0230
            10  C1b C    31.1017  -17.8641
            11  O5a O    29.9091  -16.0694
            12  C8x C    24.9579  -15.7304
            13  N1c N    32.3352  -17.1450
            14  C1b C    33.5686  -17.8641
            15  C1b C    32.3352  -15.7304
            16  C1a C    34.7845  -17.1450
            17  C1a C    33.5686  -15.0172
            18  X   Cl   39.1297  -16.5898
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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