KEGG   DRUG: Moricizine hydrochlorideHelp
Entry
D02087                      Drug                                   

Name
Moricizine hydrochloride (USP);
Ethmozine (TN)
Formula
C22H25N3O4S. HCl
Exact mass
463.1333
Mol weight
463.9775
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ic)
Phenothiazine derivative
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841];
SCN10A [HSA:6336] [KO:K04842]
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG01 Moracizine
      D02087  Moricizine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Moracizine
      D02087  Moricizine hydrochloride (USP)
    voltage-gated sodium channel (SCN2A)
     Moracizine
      D02087  Moricizine hydrochloride (USP)
    voltage-gated sodium channel (SCN3A)
     Moracizine
      D02087  Moricizine hydrochloride (USP)
    voltage-gated sodium channel (SCN4A)
     Moracizine
      D02087  Moricizine hydrochloride (USP)
    voltage-gated sodium channel (SCN5A)
     Moracizine
      D02087  Moricizine hydrochloride (USP)
    voltage-gated sodium channel (SCN8A)
     Moracizine
      D02087  Moricizine hydrochloride (USP)
    voltage-gated sodium channel (SCN9A)
     Moracizine
      D02087  Moricizine hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP1A2
   Moricizine
    D02087  Moricizine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
29560-58-5
PubChem: 
ChEBI: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C8y C    18.7714  -18.5969
            2   N1y N    17.5693  -17.8967
            3   C8y C    18.7714  -19.9974
            4   C8x C    19.9733  -17.8967
            5   C8y C    16.3498  -18.5969
            6   C5a C    17.5635  -16.5022
            7   S2x S    17.5693  -20.6976
            8   C8x C    19.9733  -20.6976
            9   C8y C    21.1871  -18.5969
            10  C8y C    16.3498  -19.9974
            11  C8x C    15.1361  -17.8967
            12  C1b C    18.7772  -15.8020
            13  O5a O    16.3440  -15.8020
            14  C8x C    21.1871  -19.9974
            15  N1b N    22.4008  -17.8910
            16  C8x C    15.1361  -20.6976
            17  C8x C    13.9166  -18.5969
            18  C1b C    18.7772  -14.4075
            19  C7a C    23.6145  -18.5853
            20  C8x C    13.9166  -19.9974
            21  N1y N    19.9209  -13.7014
            22  O7a O    24.8282  -17.8793
            23  O6a O    23.6145  -19.9916
            24  C1x C    21.1929  -14.4016
            25  C1x C    19.9850  -12.3009
            26  C1b C    26.0360  -18.5795
            27  C1x C    22.4067  -13.6956
            28  C1x C    21.1929  -11.6009
            29  C1a C    27.2496  -17.8736
            30  O2x O    22.4067  -12.2952
            31  X   Cl   31.0567  -17.9200
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    6  13 2
            13    8  14 2
            14    9  15 1
            15   10  16 1
            16   11  17 2
            17   12  18 1
            18   15  19 1
            19   16  20 2
            20   18  21 1
            21   19  22 1
            22   19  23 2
            23   21  24 1
            24   21  25 1
            25   22  26 1
            26   24  27 1
            27   25  28 1
            28   26  29 1
            29   27  30 1
            30    7  10 1
            31    9  14 1
            32   17  20 1
            33   28  30 1

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