KEGG   DRUG: D02088Help
Entry
D02088                      Drug                                   

Name
Tocainide hydrochloride (USP);
Tonocard (TN)
Formula
C11H16N2O. HCl
Exact mass
228.1029
Mol weight
228.7185
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
ATC code: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB03 Tocainide
      D02088  Tocainide hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Tocainide [ATC:C01BB03]
      D02088  Tocainide hydrochloride (USP)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Tocainide [ATC:C01BB03]
      D02088  Tocainide hydrochloride (USP)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Tocainide [ATC:C01BB03]
      D02088  Tocainide hydrochloride (USP)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Tocainide [ATC:C01BB03]
      D02088  Tocainide hydrochloride (USP)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Tocainide [ATC:C01BB03]
      D02088  Tocainide hydrochloride (USP)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Tocainide [ATC:C01BB03]
      D02088  Tocainide hydrochloride (USP)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Tocainide [ATC:C01BB03]
      D02088  Tocainide hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
35891-93-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   C8y C    24.4404  -17.9552
            2   N1b N    23.2290  -17.2622
            3   C8y C    24.4345  -19.3645
            4   C8y C    25.6517  -17.2680
            5   C5a C    22.0178  -17.9494
            6   C8x C    25.6517  -20.0693
            7   C1a C    23.2174  -20.0634
            8   C8x C    26.8572  -17.9611
            9   C1a C    25.5876  -15.8588
            10  C1c C    20.8063  -17.2506
            11  O5a O    22.0818  -19.3471
            12  C8x C    26.8631  -19.3645
            13  C1a C    19.5951  -17.9435
            14  N1a N    20.8063  -15.8471
            15  X   Cl   30.2865  -18.0600
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 1
            14    8  12 2

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