KEGG   DRUG: D02089Help
Entry
D02089                      Drug                                   

Name
Buclizine hydrochloride (USAN);
Vibazine (TN)
Formula
C28H33ClN2. 2HCl
Exact mass
504.1866
Mol weight
505.9499
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antinauseant
Remark
ATC code: 
Drug group: 
Target
H1 receptor antagonist [HSA:3269] [KO:K04149]
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE01 Buclizine
      D02089  Buclizine hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
129-74-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1c C    14.7471  -16.0735
            2   N1y N    14.7471  -14.6713
            3   C8y C    13.5312  -16.7833
            4   C8y C    15.9574  -16.7890
            5   C1x C    13.5312  -13.9789
            6   C1x C    15.9690  -13.9905
            7   C8x C    13.5370  -18.1854
            8   C8x C    12.3268  -16.0794
            9   C8x C    15.9515  -18.1854
            10  C8x C    17.1734  -16.0908
            11  C1x C    13.5020  -12.5884
            12  C1x C    15.9690  -12.5884
            13  C8x C    12.3268  -18.8836
            14  C8x C    11.1109  -16.7833
            15  C8x C    17.1618  -18.8895
            16  C8x C    18.3836  -16.8007
            17  N1y N    14.7647  -11.8902
            18  C8y C    11.1109  -18.1854
            19  C8x C    18.3778  -18.1971
            20  C1b C    14.7588  -10.4937
            21  X   Cl    9.9005  -18.8836
            22  C8y C    15.9690   -9.8014
            23  C8x C    17.1734  -10.4937
            24  C8x C    15.9690   -8.4050
            25  C8x C    18.3895   -9.8014
            26  C8x C    17.1792   -7.7009
            27  C8y C    18.3895   -8.4050
            28  C1d C    19.5938   -7.6893
            29  C1a C    19.5879   -6.2929
            30  C1a C    20.2803   -8.8996
            31  C1a C    20.9437   -7.3229
            32  X   Cl   23.6337  -11.3510
            33  X   Cl   23.6337  -12.9830
BOND        34
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 2
            13    8  14 1
            14    9  15 1
            15   10  16 2
            16   11  17 1
            17   13  18 1
            18   15  19 2
            19   17  20 1
            20   18  21 1
            21   20  22 1
            22   22  23 2
            23   22  24 1
            24   23  25 1
            25   24  26 2
            26   25  27 2
            27   27  28 1
            28   28  29 1
            29   28  30 1
            30   28  31 1
            31   12  17 1
            32   14  18 2
            33   16  19 1
            34   26  27 1

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