KEGG   DRUG: D02091Help
Entry
D02091                      Drug                                   

Name
Tripelennamine hydrochloride (USP);
PBZ-SR (TN)
Formula
C16H21N3. HCl
Exact mass
291.1502
Mol weight
291.819
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA04 Tripelennamine
      D02091  Tripelennamine hydrochloride (USP)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AC Substituted ethylene diamines
     R06AC04 Tripelennamine
      D02091  Tripelennamine hydrochloride (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Tripelennamine
    D02091  Tripelennamine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Tripelennamine
      D02091  Tripelennamine hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2D6
   Tripelennamine
    D02091  Tripelennamine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
154-69-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8x C    20.1082  -16.9077
            2   C8x C    20.1082  -18.3122
            3   C8x C    21.3245  -19.0145
            4   C8x C    22.5409  -18.3122
            5   C8y C    22.5409  -16.9077
            6   C8x C    21.3245  -16.2055
            7   N5x N    23.7572  -19.0145
            8   C8y C    24.9735  -18.3122
            9   N1c N    24.9735  -16.9077
            10  C1b C    23.7572  -16.2055
            11  C8x C    23.7572  -20.4190
            12  C8x C    24.9735  -21.1212
            13  C8x C    26.1899  -20.4190
            14  C8x C    26.1899  -19.0145
            15  C1b C    26.1749  -16.2140
            16  C1b C    27.3670  -16.9022
            17  N1c N    28.5616  -16.2124
            18  C1a C    29.7551  -16.9014
            19  C1a C    28.5616  -14.8012
            20  X   Cl   30.0300  -19.6700
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10    5  10 1
            11    7  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15    8  14 2
            16    9  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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