KEGG   DRUG: D02098Help
Entry
D02098                      Drug                                   

Name
Proparacaine hydrochloride (USP);
Alcaine (TN);
Ophthetic (TN)
Product
  Generic
Formula
C16H26N2O3. HCl
Exact mass
330.171
Mol weight
330.8502
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [topical, ophthalmic]
Remark
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA04 Proxymetacaine
      D02098  Proparacaine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN2A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN3A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN4A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN5A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN8A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN9A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN10A)
     Proparacaine
      D02098  Proparacaine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
5875-06-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    24.7791  -18.1883
            2   C8x C    23.5468  -18.8775
            3   C8x C    24.7850  -16.7810
            4   C7a C    25.9880  -18.8892
            5   C8y C    22.3495  -18.1707
            6   C8x C    23.5702  -16.0685
            7   O7a O    27.1969  -18.2000
            8   O6a O    25.9763  -20.2967
            9   C8y C    22.3555  -16.7751
            10  N1a N    21.1289  -18.8599
            11  C1b C    28.4118  -18.9008
            12  O2a O    21.1465  -16.0626
            13  C1b C    29.6265  -18.2058
            14  C1b C    19.9320  -16.7576
            15  N1c N    30.8412  -18.9066
            16  C1b C    18.7230  -16.0626
            17  C1b C    32.0502  -18.2117
            18  C1b C    30.8354  -20.3084
            19  C1a C    17.5199  -16.7576
            20  C1a C    33.2591  -18.9125
            21  C1a C    32.0385  -21.0209
            22  X   Cl   32.0601  -15.9134
BOND        21
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 1
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21    6   9 2

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