KEGG   DRUG: D02102Help
Entry
D02102                      Drug                                   

Name
Methadone hydrochloride (JAN/USP);
Dolophine hydrochloride (TN)
Product
  Generic
METHADONE HYDROCHLORIDE (American Health Packaging), METHADONE HYDROCHLORIDE (Ascend Laboratories), METHADONE HYDROCHLORIDE (Blenheim Pharmacal), METHADONE HYDROCHLORIDE (Bryant Ranch Prepack), METHADONE HYDROCHLORIDE (Bryant Ranch Prepack), METHADONE HYDROCHLORIDE (H.J. Harkins Company), METHADONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METHADONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METHADONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METHADONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METHADONE HYDROCHLORIDE (Mallinckrodt), METHADOSE (Mallinckrodt), METHADONE HYDROCHLORIDE (Mallinckrodt), METHADONE HYDROCHLORIDE (Physicians Total Care), METHADONE HYDROCHLORIDE (Roxane Laboratories), METHADONE HYDROCHLORIDE (Roxane Laboratories), METHADONE HYDROCHLORIDE (Roxane Laboratories), METHADONE HYDROCHLORIDE (STAT Rx USA LLC), METHADONE HYDROCHLORIDE (VistaPharm), METHADONE HYDROCHLORIDE (VistaPharm), METHADONE HYDROCHLORIDE (VistaPharm), METHADONE HYDROCHLORIDE (VistaPharm)
Formula
C21H27NO. HCl
Exact mass
345.1859
Mol weight
345.9061
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Analgesic [narcotic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Synthetic opioid
Target
mu-opioid receptor agonist [HSA:4988] [KO:K04215];
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Opioid analgesics
Opioid receptor agonists/antagonists
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC02 Methadone
      D02102  Methadone hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Methadone
    D02102  Methadone hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8219  Others
     D02102  Methadone hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    mu-opioid receptor
     Methadone
      D02102  Methadone hydrochloride (USP)
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Methadone
      D02102  Methadone hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2B6
   Methadone
    D02102  Methadone hydrochloride (JAN/USP)
  CYP3A4
   Methadone
    D02102  Methadone hydrochloride (JAN/USP)
 Inhbitors
  CYP2D6
   Methadone
    D02102  Methadone hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
1095-90-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Cl   38.2670  -13.6502
            2   C8x C    28.2100  -15.5400
            3   C8x C    28.2100  -16.9400
            4   C8x C    29.4224  -17.6400
            5   C8x C    30.6349  -16.9400
            6   C8y C    30.6349  -15.5400
            7   C8x C    29.4224  -14.8400
            8   C8x C    33.0597  -16.9400
            9   C8y C    33.0597  -15.5400
            10  C1d C    31.8473  -14.8400
            11  C8x C    34.2722  -17.6400
            12  C8x C    35.4846  -16.9400
            13  C8x C    35.4846  -15.5400
            14  C8x C    34.2722  -14.8400
            15  C1b C    31.8473  -13.4400
            16  C1c C    33.0618  -12.7388
            17  C5a C    29.7949  -13.7200
            18  C1a C    34.2583  -13.4298
            19  N1c N    33.0618  -11.3402
            20  C1a C    34.2579  -10.6495
            21  C1a C    31.8330  -10.6306
            22  O5a O    29.7949  -12.3200
            23  C1b C    28.6052  -14.4159
            24  C1a C    27.4094  -13.7343
BOND        24
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14    9  14 2
            15   10  15 1
            16   15  16 1
            17   10  17 1
            18   16  18 1
            19   16  19 1
            20   19  20 1
            21   19  21 1
            22   17  22 2
            23   17  23 1
            24   23  24 1

» Japanese version   » Back

DBGET integrated database retrieval system