KEGG   DRUG: D02129Help
Entry
D02129                      Drug                                   

Name
Doxycycline hydrochloride hydrate (JP16);
Doxycycline hyclate (USP);
DOXY;
Doryx (TN);
Periostat (TN);
Vibra-tabs (TN)
Product
  Generic
DOXY 100 (Fresenius Kabi USA), DOXY 100 (Fresenius Kabi USA), DOXYCYCLINE (General Injectables & Vaccines), DOXYCYCLINE (Mylan Institutional LLC), DOXYCYCLINE HYCLATE (A-S Medication Solutions LLC), DOXYCYCLINE HYCLATE (A-S Medication Solutions LLC), DOXYCYCLINE HYCLATE (A-S Medication Solutions LLC), DOXYCYCLINE HYCLATE (Actavis Elizabeth LLC), DOXYCYCLINE (Aidarex Pharmaceuticals LLC), DOXYCYCLINE HYCLATE (Aidarex Pharmaceuticals LLC), DOXYCYCLINE HYCLATE (Aidarex Pharmaceuticals LLC), DOXYCYCLINE HYCLATE (Aidarex Pharmaceuticals LLC), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE HYCLATE (Apace Packaging LLC), DOXYCYCLINE HYCLATE (Aphena Pharma Solutions (Formerly TestPak)), DOXYCYCLINE HYCLATE (Aphena Pharma Solutions - New Jersey), DOXYCYCLINE HYCLATE (Aphena Pharma Solutions - Tennessee), DOXYCYCLINE HYCLATE (Apothecary Shop Wholesale), DOXYCYCLINE HYCLATE (AvKARE), DOXYCYCLINE HYCLATE (AvPAK), DOXYCYCLINE HYCLATE (Blenheim Pharmacal), DOXYCYCLINE HYCLATE (Blenheim Pharmacal), DOXYCYCLINE HYCLATE (Blu Pharmaceuticals), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (C.O. Truxton), DOXYCYCLINE HYCLATE (C.O. Truxton), DOXYCYCLINE HYCLATE (CHARTWELL GOVERNMENTAL & SPECIALTY RX LLC), DOXYCYCLINE (Cardinal Health), DOXYCYCLINE HYCLATE (Cardinal Health), DOXYCYCLINE (Cardinal Health), DOXYCYCLINE HYCLATE (Clinical Solutions Wholesale), DOXYCYCLINE HYCLATE (Contract Pharmacy Services-PA), DOXYCYCLINE HYCLATE (CorePharma), DOXYCYCLINE HYCLATE (DAVA Pharmaceuticals), DOXYCYCLINE HYCLATE (DAVA Pharmaceuticals), DOXYCYCLINE HYCLATE (Dispensing Solutions), DOXY 100 (General Injectables & Vaccines), DOXYCYCLINE HYCLATE (Global Pharmaceuticals), DOXYCYCLINE HYCLATE (Golden State Medical Supply), DOXYCYCLINE (Golden State Medical Supply), DOXYCYCLATE HYCLATE (Golden State Medical Supply), DOXYCYCLINE HYCLATE (H.J. Harkins Company), DOXYCYCLINE HYCLATE (HHS/Program Support Center/Supply Service Center), DOXYCYCLINE HYCLATE (HHS/Program Support Center/Supply Service Center), DOXYCYCLINE HYCLATE (HHS/Program Support Center/Supply Service Center), DOXYCYCLINE HYCLATE (Heritage Pharmaceuticals), DOXYCYCLINE HYCLATE CAPSULES (Hikma Pharmaceutical), DOXYCYCLINE HYCLATE (IVAX Pharmaceuticals), DOXYCYCLINE (Keltman Pharmaceuticals), DOXYCYCLINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DOXYCYCLINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DOXYCYCLINE HYCLATE (Lake Erie Medical DBA Quality Care Products LLC), DOXYCYCLINE HYCLATE (Lannett Company), DOXYCYCLINE HYCLATE (Larken Laboratories), DOXYCYCLINE HYCLATE (Legacy Pharmaceutical Packaging), DOXYCYCLINE (Legacy Pharmaceutical Packaging), DOXYCYCLINE HYCLATE (Liberty Pharmaceuticals), DOXYCYCLATE HYCLATE (Liberty Pharmaceuticals), DOXYCYCLINE (Liberty Pharmaceuticals), DOXYCYCLINE HYCLATE (Life Line Home Care Services), DOXYCYCLINE (Major Pharmaceuticals), DOXYCYCLINE HYCLATE (Major Pharmaceuticals), DOXYCYCLINE HYCLATE (Major Pharmaceuticals), DOXYCYCLINE HYCLATE (MedVantx), MORGIDOX (Medimetriks Pharmaceuticals), DOXYCYCLINE HYCLATE (Midlothian Laboratories), DOXYCYCLINE HYCLATE (Mutual Pharmaceutical Company), DOXYCYCLINE HYCLATE (Mutual Pharmaceutical Company), DOXYCYCLINE HYCLATE (Mylan Pharmaceuticals), DOXYCYCLINE HYCLATE (Mylan Pharmaceuticals), OCUDOX (OCuSOFT), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE (Pfizer Laboratories Div Pfizer), DOXYCYCLINE HYCLATE (Physicians Total Care), DOXYCYCLINE HYCLATE (Physicians Total Care), DOXYCYCLINE HYCLATE (Preferred Pharmaceuticals), DOXYCYCLINE HYCLATE (Preferred Pharmaceuticals), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE HYCLATE (Rebel Distributors Corp), DOXYCYCLINE HYCLATE (Rebel Distributors Corp), DOXYCYCLINE (Rebel Distributors Corp.), DOXYCYCLINE HYCLATE (STAT Rx USA LLC), DOXYCYCLINE HYCLATE (Safecor Health), DOXYCYCLINE (St Marys Medical Park Pharmacy), DOXYCYCLINE HYCLATE (State of Florida DOH Central Pharmacy), DOXYCYCLINE HYCLATE (State of Florida DOH Central Pharmacy), DOXYCYCLINE HYCLATE (State of Florida DOH Central Pharmacy), DOXYCYCLINE HYCLATE (State of Florida DOH Central Pharmacy), DOXYCYCLINE HYCLATE (Unit Dose Services), DOXYCYCLINE HYCLATE (VersaPharm Incorporated), DOXYCYCLINE HYCLATE (Watson Laboratories), DOXYCYCLINE HYCLATE (West-Ward Pharmaceutical Corp), DOXYCYCLATE HYCLATE (West-Ward Pharmaceutical Corp), DOXYCYCLINE (West-Ward Pharmaceutical Corp), ALODOX (OCuSOFT)
Formula
(C22H24N2O8)2. 2HCl. C2H6O. H2O
Exact mass
1024.3123
Mol weight
1025.8747
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Semisynthetic tetracycline
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB22 Doxycycline
      D02129  Doxycycline hydrochloride hydrate (JP16); Doxycycline hyclate (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA02 Doxycycline
      D02129  Doxycycline hydrochloride hydrate (JP16); Doxycycline hyclate (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Doxycycline
    D02129  Doxycycline hydrochloride hydrate (JP16); Doxycycline hyclate (USP)
 Dental and Oral Agents
  Doxycycline
   D02129  Doxycycline hydrochloride hydrate (JP16); Doxycycline hyclate (USP)
 Dermatological Agents
  Doxycycline
   D02129  Doxycycline hydrochloride hydrate (JP16); Doxycycline hyclate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D02129  Doxycycline hydrochloride hydrate (JP16); Doxycycline hyclate (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Doxycycline
      D02129  Doxycycline hydrochloride hydrate (JP16); Doxycycline hyclate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02129  Doxycycline hydrochloride hydrate
BRITE hierarchy
Other DBs
CAS: 
24390-14-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        70
            1   C1a C    37.7489  -12.8084
            2   C1b C    38.9644  -12.1088
            3   O1a O    40.1800  -12.8084
            4   C1y C    27.9308  -15.6197
            5   C1z C    27.9590  -16.9683
            6   C1y C    29.1130  -14.9598
            7   C1y C    26.7715  -14.9311
            8   C2y C    26.7429  -17.6341
            9   C5x C    29.0729  -17.6626
            10  C2y C    30.2664  -15.6541
            11  C1y C    25.5893  -15.5968
            12  C2y C    25.6479  -16.9510
            13  O1a O    26.7372  -18.9940
            14  C2y C    30.2549  -17.0028
            15  O5x O    29.0252  -19.0227
            16  O1a O    31.4603  -14.9943
            17  C1y C    24.4188  -14.9138
            18  C5x C    24.4073  -17.6283
            19  C5a C    31.4200  -17.7029
            20  C8y C    23.2479  -15.5854
            21  C8y C    23.2422  -16.9453
            22  O5x O    24.4073  -18.9824
            23  N1a N    32.6080  -17.0372
            24  O5a O    31.4482  -19.0628
            25  C8x C    22.0598  -14.9081
            26  C8y C    22.0657  -17.6226
            27  C8x C    20.8891  -15.5910
            28  C8x C    20.8891  -16.9510
            29  O1a O    22.0657  -18.9824
            30  C1a C    24.4240  -13.2010
            31  N1c N    29.1354  -12.7712
            32  C1a C    30.3355  -12.1044
            33  C1a C    27.9578  -12.0654
            34  O1a O    26.7614  -13.2147
            35  O1a O    27.9056  -18.3392
            36  X   Cl   38.8478  -15.3293
            37  O0  O    39.5477  -17.8490
            38  C1y C    27.9308  -15.6197
            39  C1z C    27.9590  -16.9683
            40  C2y C    26.7429  -17.6341
            41  C2y C    25.6479  -16.9510
            42  C5x C    24.4073  -17.6283
            43  C8y C    23.2422  -16.9453
            44  C8y C    22.0657  -17.6226
            45  C8x C    20.8891  -16.9510
            46  C8x C    20.8891  -15.5910
            47  C8x C    22.0598  -14.9081
            48  C8y C    23.2479  -15.5854
            49  C1y C    24.4188  -14.9138
            50  C1y C    25.5893  -15.5968
            51  C1y C    26.7715  -14.9311
            52  O1a O    26.7614  -13.2147
            53  C1a C    24.4240  -13.2010
            54  O1a O    22.0657  -18.9824
            55  O5x O    24.4073  -18.9824
            56  O1a O    26.7372  -18.9940
            57  C5x C    29.0729  -17.6626
            58  C2y C    30.2549  -17.0028
            59  C5a C    31.4200  -17.7029
            60  N1a N    32.6080  -17.0372
            61  O5a O    31.4482  -19.0628
            62  C2y C    30.2664  -15.6541
            63  O1a O    31.4603  -14.9943
            64  C1y C    29.1130  -14.9598
            65  N1c N    29.1354  -12.7712
            66  C1a C    30.3355  -12.1044
            67  C1a C    27.9578  -12.0654
            68  O5x O    29.0252  -19.0227
            69  O1a O    27.9056  -18.3392
            70  X   Cl   38.8478  -15.3293
BOND        72
            1     1   2 1
            2     2   3 1
            3     8  12 2
            4     8  13 1
            5     9  14 1
            6     9  15 2
            7    10  16 1
            8    11  17 1
            9    12  18 1
            10   14  19 1
            11   17  20 1
            12   18  21 1
            13   18  22 2
            14   19  23 1
            15   19  24 2
            16   20  25 1
            17   21  26 1
            18   25  27 2
            19   26  28 2
            20   26  29 1
            21   10  14 2
            22   11  12 1
            23   20  21 2
            24   27  28 1
            25   17  30 1 #Down
            26    6  31 1 #Down
            27    4   5 1
            28   31  32 1
            29    4   6 1
            30   31  33 1
            31    4   7 1
            32    5   8 1
            33    5   9 1
            34    7  34 1 #Down
            35    6  10 1
            36    5  35 1 #Down
            37    7  11 1
            38   40  41 2
            39   40  56 1
            40   57  58 1
            41   57  68 2
            42   62  63 1
            43   50  49 1
            44   41  42 1
            45   58  59 1
            46   49  48 1
            47   42  43 1
            48   42  55 2
            49   59  60 1
            50   59  61 2
            51   48  47 1
            52   43  44 1
            53   47  46 2
            54   44  45 2
            55   44  54 1
            56   62  58 2
            57   50  41 1
            58   48  43 2
            59   46  45 1
            60   49  53 1 #Down
            61   64  65 1 #Down
            62   38  39 1
            63   65  66 1
            64   38  64 1
            65   65  67 1
            66   38  51 1
            67   39  40 1
            68   39  57 1
            69   51  52 1 #Down
            70   64  62 1
            71   39  69 1 #Down
            72   51  50 1
BRACKET     1    20.0900  -19.8800   20.0900  -10.9900
            1    34.3700  -10.9900   34.3700  -19.8800
            1  2
 ORIGINAL  1    4   5   8  12  18  21  26  28  27  25  20  17  11  35   7  36
            1   30  29  22  13   9  14  19  23  24  10  16   6  31  32  33  15
            1   37  34
 REPEAT    1   40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55
            1   56  57  58  59  60  61  62  63  64  65  66  67  68  69  70  71
            1   72  73
            2    37.1700  -16.1700   37.1700  -14.4200
            2    39.7600  -14.4200   39.7600  -16.1700
            2  2
 ORIGINAL  2   38
 REPEAT    2   74

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