KEGG   DRUG: D02134Help
Entry
D02134                      Drug                                   

Name
Azithromycin hydrate (JP16);
Azithromycin dihydrate;
Zithromac (TN);
Zmax (TN)
Product
  Generic
Formula
C38H72N2O12. 2H2O
Exact mass
784.5297
Mol weight
785.015
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Comment
Semisynthetic macrolide
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6149  Others
     D02134  Azithromycin hydrate (JP16)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA10 Azithromycin
      D02134  Azithromycin hydrate (JP16)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Azithromycin
    D02134  Azithromycin hydrate (JP16)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Azithromycin [ATC:J01FA10]
      D02134  Azithromycin hydrate (JP16)
BRITE hierarchy
Other DBs
CAS: 
117772-70-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        54
            1   C1y C    24.7580  -16.6914
            2   C1y C    23.5463  -17.3176
            3   O2a O    26.3209  -17.6570
            4   C1z C    24.8046  -15.3624
            5   C1y C    23.5462  -18.6405
            6   C1a C    22.7374  -16.2886
            7   C1y C    27.6732  -16.8903
            8   C1x C    24.0087  -14.7889
            9   C1a C    25.9698  -15.9186
            10  O1a O    25.9815  -14.6425
            11  O2a O    24.2837  -20.5664
            12  C1y C    22.3930  -19.2846
            13  C1y C    28.3990  -18.1312
            14  O2x O    28.3873  -15.6375
            15  C1y C    24.4887  -13.5242
            16  C1y C    25.8876  -21.2806
            17  C7x C    21.2690  -18.5879
            18  C1a C    22.3637  -20.6075
            19  C1y C    29.8333  -18.1195
            20  O1a O    27.6849  -19.3841
            21  C1y C    29.8273  -15.6375
            22  C1x C    23.6926  -12.7049
            23  C1a C    25.5074  -12.9684
            24  C1x C    25.8876  -22.7265
            25  O2x O    27.1289  -20.5664
            26  O7x O    21.2925  -17.2650
            27  O6a O    20.3146  -19.5655
            28  C1x C    30.5415  -16.8786
            29  N1c N    30.5532  -19.3664
            30  C1a C    30.5415  -14.3907
            31  N1y N    22.4751  -12.6639
            32  C1z C    27.1289  -23.4407
            33  C1y C    28.3755  -21.2806
            34  C1y C    20.1627  -16.5917
            35  C1a C    31.9173  -20.2738
            36  C1a C    31.8469  -18.6699
            37  C1y C    21.3219  -13.2902
            38  C1a C    22.5041  -11.2941
            39  C1y C    28.3755  -22.7265
            40  O2a O    27.1172  -24.7754
            41  C1a C    29.6166  -20.5664
            42  C1z C    20.1511  -15.2630
            43  C1b C    19.0038  -17.2124
            44  C1y C    21.3160  -14.6308
            45  C1a C    20.1628  -12.6112
            46  O1a O    29.6166  -23.4407
            47  C1a C    28.2703  -25.4544
            48  C1a C    18.8634  -15.7723
            49  O1a O    19.0038  -14.1742
            50  C1a C    18.9744  -18.5410
            51  O1a O    22.4633  -15.3039
            52  C1a C    25.9163  -24.1408
            53  O0  O    35.0000  -23.3800
            54  O0  O    35.0000  -23.3800
BOND        54
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     7   3 1 #Down
            7     4   8 1
            8     4   9 1 #Down
            9     4  10 1 #Up
            10    5  11 1 #Down
            11    5  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15   16  11 1 #Down
            16   12  17 1
            17   12  18 1 #Up
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   15  22 1
            22   15  23 1 #Down
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   19  29 1 #Down
            29   21  30 1 #Down
            30   22  31 1
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   29  35 1
            35   29  36 1
            36   31  37 1
            37   31  38 1
            38   32  39 1
            39   32  40 1 #Down
            40   33  41 1 #Up
            41   34  42 1
            42   34  43 1 #Down
            43   37  44 1
            44   37  45 1 #Up
            45   39  46 1 #Down
            46   40  47 1
            47   42  48 1 #Down
            48   42  49 1 #Up
            49   43  50 1
            50   44  51 1 #Up
            51   21  28 1
            52   33  39 1
            53   42  44 1
            54   32  52 1 #Up
BRACKET     1    33.1100  -24.4300   33.1100  -22.4700
            1    35.4200  -22.4700   35.4200  -24.4300
            1  2
 ORIGINAL  1   53
 REPEAT    1   54

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